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AJBLS · Lens · Molecular Docking Studies: Hepatitis C Viral-RNA-Dependent RNA Polymerase (RdRp) Inhibitory Activity of Siddha Herbal Formulation Sittramutti khirutham (SK)

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Article · Volume 14, Issue 2 · pp. 426–433

Molecular Docking Studies: Hepatitis C Viral-RNA-Dependent RNA Polymerase (RdRp) Inhibitory Activity of Siddha Herbal Formulation Sittramutti khirutham (SK)

Medini Elanchezhian1, Suresh Ramasamy2, Abarna Balasubramani3, Lakshmanaraj Chidambaram1

  1. 1Department of Siddhar Yoga Maruthuvam, Government Siddha Medical College, Chennai, Tamil Nadu, INDIA.
  2. 2Department of Gunapadam, National Institute Siddha, Chennai, Tamil Nadu, INDIA.
  3. 3Department of Nanju Maruthuvam, National Institute Siddha, Chennai, Tamil Nadu, INDIA.

Abstract

Background: Docking studies of Sittramutti khirutham (SK) compounds against HCV RdRp (PDB:3MWV) were performed to evaluate inhibitory potential.Results: Compounds such as Curcumin, Maslinic acid, Arjungenin, Andrograpanin, Andrographolide, and Epiafzelechin showed 2–3 interactions with active residues, indicating promising RdRp inhibition.Conclusion: Docking suggests SK compounds may inhibit HCV RdRp and warrant further pharmacological validation.

Keywords: Hepatitis C; Molecular docking; Siddha

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