Molecular Docking Studies: Hepatitis C Viral-RNA-Dependent RNA Polymerase (RdRp) Inhibitory Activity of Siddha Herbal Formulation Sittramutti khirutham (SK)
Medini Elanchezhian1, Suresh Ramasamy2, Abarna Balasubramani3, Lakshmanaraj Chidambaram1
- 1Department of Siddhar Yoga Maruthuvam, Government Siddha Medical College, Chennai, Tamil Nadu, INDIA.
- 2Department of Gunapadam, National Institute Siddha, Chennai, Tamil Nadu, INDIA.
- 3Department of Nanju Maruthuvam, National Institute Siddha, Chennai, Tamil Nadu, INDIA.
CORRESPONDENCE
Dr. Medini Elanchezhian PG Scholar, Department of Siddhar Yoga Maruthuvam, Government Siddha Medical College, Chennai-600106, Tamil Nadu, INDIA.
Received: 07-02-2025; Revised: 17-03-2025; Accepted: 24-06-2025.
Volume 14, Issue 2 · pp. 426–433 · PUBLISHED May-Aug 2025 · DOI: 10.5530/ajbls.20251508
ABSTRACT
Background: Docking studies of Sittramutti khirutham (SK) compounds against HCV RdRp (PDB:3MWV) were performed to evaluate inhibitory potential. Results: Compounds such as Curcumin, Maslinic acid, Arjungenin, Andrograpanin, Andrographolide, and Epiafzelechin showed 2–3 interactions with active residues, indicating promising RdRp inhibition. Conclusion: Docking suggests SK compounds may inhibit HCV RdRp and warrant further pharmacological validation.
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Elanchezhian, M., Ramasamy, S., Balasubramani, A., & Chidambaram, L. (2025). Molecular Docking Studies: Hepatitis C Viral-RNA-Dependent RNA Polymerase (RdRp) Inhibitory Activity of Siddha Herbal Formulation Sittramutti khirutham (SK). Asian Journal of Biological and Life sciences, 14(2), 426–433. https://doi.org/10.5530/ajbls.20251508