Volume 19, Issue 3

Souman Samanta, Sneha Sah

pp. 326–337 · DOI: 10.5530/ijopp.20260558 · 2026

Pharmacovigilance (PV) and Clinical Data Management (CDM) are increasingly linked domains that are of enormous importance in ensuring the safety of drugs throughout the entire process. In the review, the evolving landsca…

Sudesh Sivakumar, Dhinesh Kumar Sambasivam, Suresh Kumar Krishnan

pp. 338–345 · DOI: 10.5530/ijopp.20260625 · 2026

Nanotechnology has profoundly transformed Drug Delivery Systems (DDS), with Inorganic Nanoparticles (INPs) emerging as promising and versatile carriers owing to their exceptional stability, tunable size, and unique physi…

Syed Zia Inamdar, Sushil Kumar Londhe, Hadi Abdul, Patil Rakshit, Patil Mallanagouda

pp. 346–351 · DOI: 10.5530/ijopp.20260676 · 2026

Drug-Related Problems (DRPs) are common in hospitalized pediatric patients and may adversely affect therapeutic outcomes. The present study aimed to assess the prevalence and pattern of DRPs in pediatric inpatients and t…

Asha Pillai, Susan Uthup

pp. 352–360 · DOI: 10.5530/ijopp.20260677 · 2026

Introduction: Nephrotic syndrome is a prevalent disorder in children, marked by the abnormal excretion of protein from the bloodstream into the urine due to compromised glomeruli. Conventional treatments such as corticos…

Pooja Panchawat, Manish Dhakar, Narendra Bheemraj Parihar, Renu Mishra, Mahendra Singh Rathore

pp. 361–366 · DOI: 10.5530/ijopp.20260680 · 2026

Background: Platinum-based chemotherapy, including cisplatin and carboplatin, is a standard treatment for head and neck cancers. However, Gastrointestinal (GI) toxicity remains a common adverse effect that may affect tre…

Syed Zia Inamdar, Inamul Hoque, Sushil Kumar Londhe, Sandeep Patil, Bentoor Sanjeev, Siddanagouda Biradar, Ramakanth Baloorkar, Santosh Patil

pp. 367–373 · DOI: 10.5530/ijopp.20260687 · 2026

Background: Chronic Kidney Disease (CKD) is an increasing global health challenge that significantly influences drug pharmacokinetics and pharmacodynamics. Impaired renal function reduces drug clearance, raising the like…

Chetan Malviya, Narendra Bheemraj Parihar, Manish Dhakar, Sunil Vishnoi, Ritesh Kumar, Mahendra Singh Rathore, Lalit Shrimali

pp. 374–379 · DOI: 10.5530/ijopp.20260685 · 2026

Introduction: Proton Pump Inhibitors (PPIs) are among the most frequently prescribed drugs for the management and prevention of acid-related gastrointestinal disorders. Although PPIs are effective and well tolerated, the…

Kumar Masum, Shibi Mary Thomas, Balakeshwa Ramaiah

pp. 380–388 · DOI: 10.5530/ijopp.20260707 · 2026

Introduction: Breast cancer is common in India, with variable responses to Neoadjuvant Chemotherapy (NACT), which is essential for tumor downstaging, breast conservation, and prognostic assessment. This study evaluated t…

Muhammed Salah, Muhammed Shas, Nahdha K, Shariba Parveen, Anjali C S, Kameswaran R, Sirajudheen M K

pp. 389–391 · DOI: 10.5530/ijopp.20260569 · 2026

Lichen Planus Pigmentosus (LPP) is a rare variant of lichen planus that presents as dark brown to grey hyperpigmented macules over sun-exposed areas such as the face, neck, and upper limbs. This case report aims to descr…

C. Dhandapani, Kavitha A

pp. 392–394 · DOI: 10.5530/ijopp.20260604 · 2026

Acute Myeloid Leukemia (AML) with mixed phenotypic features represents a rare and high-risk subset of childhood leukemia. This case highlights a pediatric patient harboring a novel ZNF348/ SF11 fusion and NRAS mutation, …

Niya Catherine

pp. 395–396 · DOI: 10.5530/ijopp.20260477 · 2026

Etoricoxib is a COX 2 selective inhibitor it has one of the highest cox 2 selectivity and is one of the newer coxib class drug. Etoricoxib is an orally active cox 2 selective inhibitor that acts by blocking the cox 2 enz…

Parshant Pokhriyal, Muskan Kumari, Damini Kharb, Subodh Gururani, Anuj Nautiyal

pp. 397–402 · DOI: 10.5530/ijopp.20260514 · 2026

Dry gangrene is a severe complication of vascular insufficiency, often associated with Peripheral Arterial Disease (PAD), diabetes, or autoimmune conditions like Rheumatoid Arthritis (RA). This case report presents a pat…

Syed Zia Inamdar, Chirasini Swapna, Pavan Kumar, Sushilkumar Londhe, Sanjeev Bentoor, Ajith Janagond, Shrinivas Raikar

pp. 403–406 · DOI: 10.5530/ijopp.20260623 · 2026

Toxic Epidermal Necrolysis (TEN) is a rare, life-threatening mucocutaneous disorder, most often triggered by medications and less frequently by infections. It is clinically characterized by widespread erythema, epidermal…

Sukesh Edavalath, Shahsadhi Ittikapparambil Palakkal, Shinad Achamveetil

pp. 407–410 · DOI: 10.5530/ijopp.20260594 · 2026

Reactive arthritis is a rare complication following Bacillus Calmette-Guérin (BCG) therapy for bladder cancer, often presenting with joint pain and systemic symptoms. A patient with high-risk non-muscle-invasive bladder …

Prathap Arumugam, Angelin Grace Thomas, Ann Jency Arul Durai Singam, Dhivyaprasath Palaniyappan

pp. 411–415 · DOI: 10.5530/ijopp.20260554 · 2026

A 73-year-old female with fever, muscle weakness, and back pain was diagnosed with Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP), a subtype of Guillain-Barré Syndrome (GBS). Laboratory findings showed el…

Idris Dawaiwala, Soniya Bhagat, Kapil Zirpe, Aniket Shah, Abhijeet Deshmukh, Prasad Muglikar

pp. 416–419 · DOI: 10.5530/ijopp.20260624 · 2026

Polymyxin B is a last-line therapy for multidrug-resistant Gram-negative infections, with nephrotoxicity and neurotoxicity being the most recognized adverse effects. Cutaneous and vascular complications are rare and unde…

Shaik Sharmila, Pavan Kumar Yanamadala, Janani Gope, Damini Sai Kumar Jammula, Bhargavi Devi Mandarapu, Rama Rao Nadendla

pp. 420–425 · DOI: 10.5530/ijopp.20260662 · 2026

Background: Pseudo-Foster Kennedy Syndrome (PFKS) represents an uncommon neuro-ophthalmic condition distinguished by the presence of ipsilateral optic atrophy alongside contralateral papilledema, occurring in the absence…

Atiya Rajgoli, Aiiravat Tambe, Ishan Tewari, Mandati Santhosh Reddy, Pratiksha Kini, Bhavana Doshi

pp. 426–430 · DOI: 10.5530/ijopp.20260656 · 2026

Lichenoid Drug Eruption (LDE) is a rare, immune-mediated adverse cutaneous reaction that closely mimics idiopathic lichen planus. Isoniazid, a first-line anti-tubercular drug, has been infrequently implicated as a causat…

Angelin Grace Thomas, Aswini Suresh, Ann Jency Arul Durai Singam

pp. 431–434 · DOI: 10.5530/ijopp.20260673 · 2026

Costochondritis is a self-limiting inflammatory condition affecting the costochondral and chondrosternal joints, often presenting with localised chest pain. This case report discusses a 50-year-old male with a history of…

Tellagorla Bharathi, Siram Teja Manikanta, Viswanadhapalli Jaswanth Raju, Katragadda Pradeepthi, Ghanta Vijayakumar, Ghanta Vijaya Kumar

pp. 435–437 · DOI: 10.5530/ijopp.20260688 · 2026

The antithyroid drug methimazole is used to treat patients with hyperthyroidism. Agranulocytosis is a rare and life-threatening adverse effect of the drug, characterized by a reduced circulating white blood cell count, w…