Article · Volume 7, Issue 2 · pp. 37–39

Toxic Epidermal Necrolysis induced by Phenytoin: A Case Study

Manoj Kumar M¹, Yogendra M², Karthik M¹, Gowthami B¹, Yogananda R¹, Bharathi DR¹

¹Department of Pharmacy Practice, SJM College of Pharmacy Chitradurga-577502, Karnataka, India.
²Department of Dermatology, Basaveswara Medical College Hospital & Research Center, Chitradurga-577502, Karnataka, India.

Abstract

Toxic epidermal necrolysis (TEN) is severe adverse cutaneous drug reaction that predominantly involves the skin and mucous membranes. It is usually induced by medications. Anti-convulsants such as phenytoin, carbamazepine and phenobarbital have been enlisted as high risk drugs for causing TEN.Objectives: The main objective of this case report is to evaluate the importance of detection, assessment and reporting of an adverse drug reaction and to improve the medication adherence.Methods: This is an observational type of case report which we observed in our hospital on regular ward rounds.Results: This is a case report of Toxic epidermal necrolysis due to a Phenytoin which was used in the treatment of epilepsy in a 25 year old female patient. Causality assessment of the event with Naranjo’ scale suggest “Probable”.Conclusion: Proper counselling to the patient regarding the use of medications is of utmost importance, in such life threatening conditions where treatment guidelines remain hazy.

Keywords: Adverse drug reaction; Toxic epidermal necrolysis; Phenytoin

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