Toxic Epidermal Necrolysis induced by Phenytoin: A Case Study
Manoj Kumar M1★, Yogendra M2, Karthik M1, Gowthami B1, Yogananda R1, Bharathi DR1★ Corresponding author
- 1Department of Pharmacy Practice, SJM College of Pharmacy Chitradurga-577502, Karnataka, India.
- 2Department of Dermatology, Basaveswara Medical College Hospital & Research Center, Chitradurga-577502, Karnataka, India.
CORRESPONDENCE
Manoj Kumar M
Department of Pharmacy Practice, SJM College of Pharmacy Chitradurga-577502, Karnataka, India.
Received: 04-06-2014; Accepted: 16-06-2014.
Volume 7, Issue 2 · pp. 37–39 · PUBLISHED · DOI: 10.5530/ijopp.7.2.8
ABSTRACT
Toxic epidermal necrolysis (TEN) is severe adverse cutaneous drug reaction that predominantly involves the skin and mucous membranes. It is usually induced by medications. Anti-convulsants such as phenytoin, carbamazepine and phenobarbital have been enlisted as high risk drugs for causing TEN. Objectives: The main objective of this case report is to evaluate the importance of detection, assessment and reporting of an adverse drug reaction and to improve the medication adherence. Methods: This is an observational type of case report which we observed in our hospital on regular ward rounds. Results:This is a case report of Toxic epidermal necrolysis due to a Phenytoin which was used in the treatment of epilepsy in a 25 year old female patient. Causality assessment of the event with Naranjo’ scale suggest “Probable”. Conclusion: Proper counselling to the patient regarding the use of medications is of utmost importance, in such life threatening conditions where treatment guidelines remain hazy.
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M, M. K., M, Y., M, K., B, G., R, Y., & DR, B. (). Toxic Epidermal Necrolysis induced by Phenytoin: A Case Study. Indian Journal of Pharmacy Practice, 7(2), 37–39. https://doi.org/10.5530/ijopp.7.2.8