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Indian Journal of Pharmaceutical Education and ResearchNOW IN
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IJPER · Lens · Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation

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Article · Volume 47, Issue 2 · pp. 183–187

Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation

Preeti Kulkarni1, Sonal Desai1, Pratima Tatke1, T. P. Ghule2, C.D. Chavan2, V. R. Bhate2

  1. 1C. U. Shah College Of Pharmacy, S. N. D. T. Women's University, Santacruz (W), Mumbai-400 049, India.
  2. 2Analytical Solutions, R-610, Rabale, M. I. D. C., Mumbai-400 701, India.

Abstract

The present study aims at development of method for simultaneous estimation of chloride and citrate in oral rehydration salt (ORS) by ion chromatography and its validation. The estimation was carried out with a step change gradient mode by altering concentrations of NaOH as an eluent, an anion exchange column IonPac AS11 analytical column, guard column AG11 and conductivity detector. The suppressor used was used as ASRS ULTRA. The developed method was validated as per ICH guidelines for various parameters. The method is useful for determining the contents of chloride and citrate in single run from ORS.

Keywords: Ion chromatography; Oral rehydration salt; simultaneous estimation; chloride; citrate

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