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Recent articles
15 articles · what your feed deliversReview Article
Advancing Breast Cancer: Strategies to Counteract Taxane Resistance in Her2-Positive and Triple-Negative Breast Cancer
Deepak Thakre, Priyanka Singanwad, Milind Umekar, Amol Tatode, Nishant Awandekar, Mohammad Qutub, Ujban Mohammad Hussain
Volume 60, Issue 4S · pp. s1364–s1373 · 2026
Resistance is one of the major problems in chemotherapy during Breast Cancer (BC) treatment. Earlier treatments, such as radiation, surgery, and chemotherapy including taxane-based therapies like paclitaxel and docetaxel, play a crucial role in managing BC, particularly in…
Review Article
Natural Products and Cellular Senescence Research: A Scientometric Analysis of Global Trends, Thematic Clusters, and Emerging Frontiers (2016-25)
Rashed M Almuqbil, Bandar Aldhubiab, Mueen Ahmed K. K, Chaman Sab M
Volume 60, Issue 4S · pp. s1374–s1382 · 2026
Background: Interest in natural products-polyphenols, flavonoids, terpenoids, and related phytochemicals-as candidate senotherapeutic and geroprotective agents has expanded rapidly over the past decade, yet the literature spans pharmacology, cosmetic science, food chemistry, and…
Review Article
Recent Trends in Chemistry and Pharmacology-Based Research Using Pyrrolidine Scaffolds: An Up-to-Date
Km. Anjali, Arun Kumar Mishra
Volume 60, Issue 4S · pp. s1383–s1395 · 2026
Pyrrolidine is a saturated five-membered nitrogen-containing heterocycle widely recognized as a privileged scaffold in medicinal chemistry. Its conformational flexibility, strong basicity, and hydrogen-bonding capability contribute to its broad pharmacological relevance.…
Original Article
Formulation and Evaluation of Liquisolid Tablet with Enhanced Dissolution of Ivacaftor by Using Box-Behnken Design
Manisha Dnyanoba Chate, Swaroop Rameshwarji Lahoti
Volume 60, Issue 4S · pp. s1405–s1415 · 2026
Introduction: Ivacaftor a drug falling under BCS class II due to its low solubility, with a bioavailability of around 20%. In this study, the novel liquisolid technique is used to enhance the dissolution and ultimately improve the solubility. Objectives: The primary objective…
Original Article
Development and Evaluation of Polymer-conjugated Solid Fast Dissolving Tablets of Ambroxol Hydrochloride
Vidhan Chand Bala, Mukesh Kumar Singh, Amit Kumar, Arvind Kumar Patel, Sunil Kumar Tiwari, Asheesh Kumar Gupta, Sushil Kumar
Volume 60, Issue 4S · pp. s1416–s1429 · 2026
Objectives: This study aimed to develop polymer-conjugated Fast Dissolving Tablets (FDTs) of ambroxol hydrochloride using direct compression with Amberlite IPR64 and Sodium Starch Glycolate (SSG) to achieve effective taste masking and enhance palatability and patient compliance.…
Original Article
Quality by Design Development of a Thermosensitive in situ Gel for Enhanced Ocular Delivery of Carvedilol
Anurag Rajendra Panade, Sandip Akaram Bandgar, Riya Raghunath Patil, Indrayani Sandip Bandgar
Volume 60, Issue 4S · pp. s1430–s1444 · 2026
Introduction: This research focuses on formulating a thermoresponsive in situ gel containing Carvedilol for ocular delivery, employing a Quality by Design (QbD) strategy to improve therapeutic effectiveness in glaucoma management. Carvedilol, known for its β- and α1-blocking…
Original Article
Novel Application of Mixed Solvency Concept for the Development of Topical Emulgel Formulations of Poorly Water-Soluble Drug, Piroxicam, and their Evaluations
Jitendra Singh, Prateek Sahu, Sharad Prakash Pandey, Rajesh Kumar Maheshwari
Volume 60, Issue 4S · pp. s1445–s1460 · 2026
Aim: The objective of this research was to investigate the mixed solvency concept as a means to enhance the solubility of Piroxicam and to develop an optimized microemulsion-based gel formulation suitable for topical application. Materials and Methods: Piroxicam-loaded…
Original Article
Formulation Considerations and in vitro Characterization of Polymeric Micelles Loaded with Asenapine Maleate
Zainab Eassa Jassim, Nawal Ayash Rajab, Hamid Akbari Javar
Volume 60, Issue 4S · pp. s1461–s1473 · 2026
Objectives: An effort has been utilized to incorporate ASPM into polymeric micelles using single and mixed copolymers. Materials and Methods: A thin-film hydration approach was used to create the ASPM polymeric micelles, which comprised TPGS, Solutol®HS-15, and Pluronics.…
Original Article
Evaluation of Commercial Lipstick Formulations for Compliance with BIS Standards: A Comparative Study
Deepak Sharma, Dipanjan Koley, Khushbu Mehlawat, Kavita Attri, Vijay Bhalla, Manvi Singh
Volume 60, Issue 4S · pp. s1474–s1485 · 2026
Background: The Indian cosmetic industry is experiencing rapid growth, valued at USD 8.1 billion in 2023 and projected to reach USD 18.4 billion by 2032. Among cosmetic products, lipsticks are widely used and frequently applied, raising concerns regarding cumulative exposure to…
Original Article
Optimization of Palbociclib Nano Structured Lipid Carriers Loaded Transdermal Patch with Comprehensive ex vivo Skin Permeation and Retention Research for Management of Breast Cancer
Anilkumar Shinde, Nikita Gurav, Harinath More
Volume 60, Issue 4S · pp. s1486–s1497 · 2026
Background: Palbociclib (PCB), a selective cyclin-dependent kinase 4/6 prescribe for hormone receptor-positive breast cancer, has low oral bioavailability and dose-limiting systemic toxicity. Objectives: In order to achieve prolonged drug administration and improved transdermal…
Original Article
Deferoxamine Loaded Nanoemulgel for Enhanced Wound Healing: Formulation Optimization and in vivo Evaluation
Abdullah M. Alotaibi, Anroop B. Nair, Hiral Shah, Bandar Aldhubiab, Shery Jacob, Rashed M. Almuqbil, Ahmed S. Alnaim, Jigar N. Shah
Volume 60, Issue 4S · pp. s1498–s1513 · 2026
Background: Chronic wounds remain a major clinical challenge due to impaired angiogenesis, persistent inflammation, and oxidative stress, necessitating advanced therapeutic strategies. The purpose of this research was to design, develop and evaluate deferoxamine loaded…
Original Article
Cardioprotective Effect of Mikania micrantha Kunth Leaf Extract in Isoproterenol-Induced Myocardial Injury in Experimental Animals
Lamia Yasmin, Soumen Dhara, Surajit Ghosh, Satyaki Pachal, Sumit Jana, Dibya Das, Rania Indu, Moumita Ray
Volume 60, Issue 4S · pp. s1514–s1522 · 2026
Background: Myocardial Infarction (MI), driven by oxidative stress-induced cardiomyocyte injury, is the most predisposing disease, causing prevalent mortality globally, among the various cardiovascular diseases. Present study evaluated the cardioprotective potential of the…
Original Article
Therapeutic Potential of Phyllanthus niruri Against D-Galactosamine Induced Hepatitis in Wistar Strain Albino Rats: A Study with Reference to Oxidative Stress Markers and Antioxidant Enzymes
Bhasha Shanmugam, Kondeti Ramudu Shanmugam, Meesala Gurusekhar, Ramavath Kambli Naik, Dronadula Veena Madhuri, Sahukari Ravi
Volume 60, Issue 4S · pp. s1523–s1531 · 2026
Background: Phyllanthus niruri (PN), known as Bhumyamalaki and it has been used in Ayurveda to treat liver, kidney and spleen related disorders. But till date no study was carried on the antihepatitis activity of phenolic fraction of PN. The objective of the current study was to…
Original Article
Nano-Extracts of Green-Synthesized Curcuma longa: An Innovative Approach to Breast and Colorectal Cancer Prevention
Armugam Jayasankar, Hanumanthu Rama Subba Reddy, Marapa Reddy Sowghandika, Amgoth Govardhan Naik, Narasaiah Shivakoti, Paluru Subramanyam, Kanala Somasekhar Reddy, Devarapalle Veera Nagendra Kumar, Vempapti Uday Kiran
Volume 60, Issue 4S · pp. s1532–s1543 · 2026
Aim: Curcumin, the primary bioactive agent in Curcuma longa (turmeric), is celebrated in Ayurveda for its anti-inflammatory, antioxidant, and wound-healing effects. Its clinical application is limited by poor bioavailability, despite its traditional use in treating respiratory,…
Original Article
Chromatographic and Spectroscopic Characterisation of Bioactive Compounds from Diplocyclos palmatus for Polycystic Ovary Syndrome Management
Richa Yadav, Jaya Parkash Yadav
Volume 60, Issue 4S · pp. s1544–s1552 · 2026
Aim: Polycystic ovary syndrome is a prevalent endocrine disorder that arises from hormonal imbalance, typically presenting with excessive androgen production, disrupted ovulatory cycles, and various metabolic abnormalities. Current pharmacological options often cause side…