Volume 60, Issue 4S

Deepak Thakre, Priyanka Singanwad, Milind Umekar, Amol Tatode, Nishant Awandekar, Mohammad Qutub, Ujban Mohammad Hussain

pp. s1364–s1373 · DOI: 10.5530/ijper.20261755 · 2026

Resistance is one of the major problems in chemotherapy during Breast Cancer (BC) treatment. Earlier treatments, such as radiation, surgery, and chemotherapy including taxane-based therapies like paclitaxel and docetaxel…

Rashed M Almuqbil, Bandar Aldhubiab, Mueen Ahmed K. K, Chaman Sab M

pp. s1374–s1382 · DOI: 10.5530/ijper.20265864 · 2026

Background: Interest in natural products-polyphenols, flavonoids, terpenoids, and related phytochemicals-as candidate senotherapeutic and geroprotective agents has expanded rapidly over the past decade, yet the literatur…

Km. Anjali, Arun Kumar Mishra

pp. s1383–s1395 · DOI: 10.5530/ijper.20263772 · 2026

Pyrrolidine is a saturated five-membered nitrogen-containing heterocycle widely recognized as a privileged scaffold in medicinal chemistry. Its conformational flexibility, strong basicity, and hydrogen-bonding capability…

Manisha Dnyanoba Chate, Swaroop Rameshwarji Lahoti

pp. s1405–s1415 · DOI: 10.5530/ijper.20262408 · 2026

Introduction: Ivacaftor a drug falling under BCS class II due to its low solubility, with a bioavailability of around 20%. In this study, the novel liquisolid technique is used to enhance the dissolution and ultimately i…

Vidhan Chand Bala, Mukesh Kumar Singh, Amit Kumar, Arvind Kumar Patel, Sunil Kumar Tiwari, Asheesh Kumar Gupta, Sushil Kumar

pp. s1416–s1429 · DOI: 10.5530/ijper.20262915 · 2026

Objectives: This study aimed to develop polymer-conjugated Fast Dissolving Tablets (FDTs) of ambroxol hydrochloride using direct compression with Amberlite IPR64 and Sodium Starch Glycolate (SSG) to achieve effective tas…

Anurag Rajendra Panade, Sandip Akaram Bandgar, Riya Raghunath Patil, Indrayani Sandip Bandgar

pp. s1430–s1444 · DOI: 10.5530/ijper.20263018 · 2026

Introduction: This research focuses on formulating a thermoresponsive in situ gel containing Carvedilol for ocular delivery, employing a Quality by Design (QbD) strategy to improve therapeutic effectiveness in glaucoma m…

Jitendra Singh, Prateek Sahu, Sharad Prakash Pandey, Rajesh Kumar Maheshwari

pp. s1445–s1460 · DOI: 10.5530/ijper.20266485 · 2026

Aim: The objective of this research was to investigate the mixed solvency concept as a means to enhance the solubility of Piroxicam and to develop an optimized microemulsion-based gel formulation suitable for topical app…

Zainab Eassa Jassim, Nawal Ayash Rajab, Hamid Akbari Javar

pp. s1461–s1473 · DOI: 10.5530/ijper.20263858 · 2026

Objectives: An effort has been utilized to incorporate ASPM into polymeric micelles using single and mixed copolymers. Materials and Methods: A thin-film hydration approach was used to create the ASPM polymeric micelles,…

Deepak Sharma, Dipanjan Koley, Khushbu Mehlawat, Kavita Attri, Vijay Bhalla, Manvi Singh

pp. s1474–s1485 · DOI: 10.5530/ijper.20265022 · 2026

Background: The Indian cosmetic industry is experiencing rapid growth, valued at USD 8.1 billion in 2023 and projected to reach USD 18.4 billion by 2032. Among cosmetic products, lipsticks are widely used and frequently …

Anilkumar Shinde, Nikita Gurav, Harinath More

pp. s1486–s1497 · DOI: 10.5530/ijper.20265560 · 2026

Background: Palbociclib (PCB), a selective cyclin-dependent kinase 4/6 prescribe for hormone receptor-positive breast cancer, has low oral bioavailability and dose-limiting systemic toxicity. Objectives: In order to achi…

Abdullah M. Alotaibi, Anroop B. Nair, Hiral Shah, Bandar Aldhubiab, Shery Jacob, Rashed M. Almuqbil, Ahmed S. Alnaim, Jigar N. Shah

pp. s1498–s1513 · DOI: 10.5530/ijper.20265633 · 2026

Background: Chronic wounds remain a major clinical challenge due to impaired angiogenesis, persistent inflammation, and oxidative stress, necessitating advanced therapeutic strategies. The purpose of this research was to…

Lamia Yasmin, Soumen Dhara, Surajit Ghosh, Satyaki Pachal, Sumit Jana, Dibya Das, Rania Indu, Moumita Ray

pp. s1514–s1522 · DOI: 10.5530/ijper.20262732 · 2026

Background: Myocardial Infarction (MI), driven by oxidative stress-induced cardiomyocyte injury, is the most predisposing disease, causing prevalent mortality globally, among the various cardiovascular diseases. Present …

Bhasha Shanmugam, Kondeti Ramudu Shanmugam, Meesala Gurusekhar, Ramavath Kambli Naik, Dronadula Veena Madhuri, Sahukari Ravi

pp. s1523–s1531 · DOI: 10.5530/ijper.20262824 · 2026

Background: Phyllanthus niruri (PN), known as Bhumyamalaki and it has been used in Ayurveda to treat liver, kidney and spleen related disorders. But till date no study was carried on the antihepatitis activity of phenoli…

Armugam Jayasankar, Hanumanthu Rama Subba Reddy, Marapa Reddy Sowghandika, Amgoth Govardhan Naik, Narasaiah Shivakoti, Paluru Subramanyam, Kanala Somasekhar Reddy, Devarapalle Veera Nagendra Kumar, Vempapti Uday Kiran

pp. s1532–s1543 · DOI: 10.5530/ijper.20263586 · 2026

Aim: Curcumin, the primary bioactive agent in Curcuma longa (turmeric), is celebrated in Ayurveda for its anti-inflammatory, antioxidant, and wound-healing effects. Its clinical application is limited by poor bioavailabi…

Richa Yadav, Jaya Parkash Yadav

pp. s1544–s1552 · DOI: 10.5530/ijper.20263948 · 2026

Aim: Polycystic ovary syndrome is a prevalent endocrine disorder that arises from hormonal imbalance, typically presenting with excessive androgen production, disrupted ovulatory cycles, and various metabolic abnormaliti…

Jawaher Amer Alsaiari, Abdulraheem A. Almalki, Jawaher Ayidh Alosaimi, Raja Mohammed Al-Qurashi, Bedour Abdullah Al-Qurashi, Fatima Anwar Dhafer, Ahad Amer Alsaiari

pp. s1553–s1562 · DOI: 10.5530/ijper.20264032 · 2026

Background: Globally, Breast Cancer (BC) ranks as the second most common cause of cancer-related death for women. The high mortality and recurrence rates contribute substantially to its fatality. Objectives: This researc…

Nael Abutaha, Fahd Abdo Al-Mekhlafi, Mohammed A. Wadaan

pp. s1563–s1572 · DOI: 10.5530/ijper.20263063 · 2026

Background: Juglans regia leaves contain bioactive compounds with potential anticancer effects. This study evaluated their cytotoxic activity and interactions with cancer-related targets. Materials and Methods: Leaves of…

Sanjita Das, Shruti Dhasmana, Gyas Khan

pp. s1573–s1579 · DOI: 10.5530/ijper.20261810 · 2026

Objectives: This study is targeted at investigating the nanogel formulation of a protein from the milk of goat; CSN1S2 for anxiolytic activity in mice. Materials and Methods: After isolating CSNIS2, its nanogel was formu…

Mohammad Zubair Alam, Hala Abubaker Bagabir, Mohammad Alameen Faisal Zaher, Thamer Mohammed Ahmed Alqurashi, Badrah Saeed Alghamdi, Mohsin Kazi, Athanasios Alexiou, Ghulam Md Ashraf

pp. s1580–s1593 · DOI: 10.5530/ijper.20262042 · 2026

Background: Neuroinflammation plays a critical role in the progression of neurodegenerative diseases such as multiple sclerosis, Alzheimer's, and Parkinson's disease. The Cuprizone (CPZ)- induced model is widely used to …

Navaneethakrishnan Subramanian, Vijayaraj Surendran, Rajkumar Selvam, Murugesan Vanangamudi, Thiruveni Azhagarsamy, Raghavendra Kumar Gunda

pp. s1594–s1603 · DOI: 10.5530/ijper.20263446 · 2026

Background: Bone cancer, particularly osteosarcoma, is an aggressive malignancy with poor prognosis, often resistant to conventional chemotherapy. Protocatechuic Acid (PCA), a plant-derived polyphenol, holds anticancer p…