Volume 60, Issue 4

Rikngam Gibo, Purbajit Chetia, George Hmangte Kom, Phiwansiewdor Syiem, Jyotirupa Mochahari

pp. 1351–1365 · DOI: 10.5530/ijper.20263195 · 2026

Systemic Lupus Erythematosus (SLE) is a multifactorial autoimmune disorder characterized by a breakdown in immune tolerance, leading to chronic inflammation and multiorgan damage. The pathogenesis of SLE involves complex…

Abdulmajeed M. Jali

pp. 1366–1378 · DOI: 10.5530/ijper.20264564 · 2026

Chemoresistance remains a major limitation of cancer chemotherapy, leading to therapeutic failure, tumour relapse, and poor clinical outcomes. The development of agents capable of sensitising resistant cancer cells or mo…

Helvinder Kaur, Farheen Sami, Sheikh Murtuja, Nadeem Hasan, Arun Kumar, Rajesh Sreedharan Nair, Md Sajid Ali, Neeraj Kumar Fuloria, Shahnaz Majeed, M Saquib Hasnain, Mohammed Tahir Ansari

pp. 1379–1393 · DOI: 10.5530/ijper.20261641 · 2026

Introduction: There has been a substantial paradigm shift in pharmacy education towards Outcomes-Based Education (OBE), which emphasizes the acquisition of industrial based competencies and skills among the graduates. Ob…

Km. Anjali, Arvind Raghav

pp. 1394–1408 · DOI: 10.5530/ijper.20264257 · 2026

Background: This study focused on developing fast-disintegrating tablets of ciprofloxacin hydrochloride by combining superdisintegrant technology with a novel drug-resin complex, Kyron T-314, to achieve improved dissolut…

Prasanna Shirgaonkar, Rutuja Chougale, Kiran Patil, Vibhuti Thakur, Firoj Tamboli, Somnath Bhinge, Shailendra Gurav

pp. 1409–1415 · DOI: 10.5530/ijper.20261392 · 2026

Background: The study focuses on the development and characterization of Ranolazine-loaded Solid Lipid Nanoparticles (RNZ-SLNs) to enhance therapeutic efficacy and safety in angina therapy. Materials and Methods: RNZ-SLN…

Sanjay Jayaram, Manjunath Kopparam, Abdul Waris Khan

pp. 1416–1424 · DOI: 10.5530/ijper.20261636 · 2026

Aim/Background: The objective of this study was to create a pulsincap system designed to target the Gastrointestinal Tract (GIT) and administer the asthma drug bambuterol. Materials and Methods: In vitro release tests an…

Jaya Martolia, Falguni Tandel, Hardik Soni

pp. 1425–1440 · DOI: 10.5530/ijper.20261658 · 2026

Introduction: Scientific and Ayurvedic literature provides strong evidence that plants, their phytoconstituents, and extracts have significant anti-tubercular activity. However, developing effective herbal formulations i…

Vishal Mane, Kishori Prasanna Sutar, Rashmita Kashinath Akkatangerhal

pp. 1441–1449 · DOI: 10.5530/ijper.20262581 · 2026

Objectives: The study aims to develop a novel capsaicin loaded transethosomal gel for the treatment of Post-Herpetic Neuralgia (PHN) for sustained capsaicin delivery. Materials and Methods: Transethosomes were formulated…

Ashlesh Prabhu, Arjun Prabhu, Ravindra Shenoy Udyavar, Kirankumar Hunashimarad, Mahendra Joshi, Girish Pai Kulyadi

pp. 1450–1458 · DOI: 10.5530/ijper.20262112 · 2026

Background: The pharmaceutical Industry is one of the sectors with the most stringent guidelines since it deals with human lives. Faults in the manufacturing of pharmaceutical products provide serious obstacles to assure…

Alka Ramesh Bhure, Atul Anand Phatak

pp. 1459–1468 · DOI: 10.5530/ijper.20263223 · 2026

Background: Bicalutamide, a non-steroidal anti-androgen, is commonly prescribed for the treatment of prostate cancer. A drug categorized under BCS Class II due to its low solubility and higher permeability. The inherent …

Shupei Ma, Dongyu Xie, Gang Tao, Jing Sun, Xiaowen Yu

pp. 1469–1474 · DOI: 10.5530/ijper.20260496 · 2026

Objectives: To probe the action and mechanism of Safflower Polysaccharide (SPS) on Gastric Cancer (GC) cells. Materials and Methods: qRT-PCR detected miR-6738-3p expression levels. MTT assay and flow cytometry were adopt…

Yingmei Chen, Jun Yang, Wulin Long

pp. 1475–1487 · DOI: 10.5530/ijper.20260516 · 2026

Background and Objectives: IgA nephropathy is a common immunologically mediated kidney disease. This work investigated the impact of Astragalus membranaceus Extract (AME) combined with nursing intervention on serum infla…

Sarumathi Chandrasekaran, Sai Sakthi Sridevi Kumaran, Bhuvaneswari Shanmugam, Ahamed Rofiya Begam Mohamed Samsudeen

pp. 1488–1498 · DOI: 10.5530/ijper.20263141 · 2026

Introduction: Recently, polysaccharides from plant sources have been playing a crucial role in various therapeutic applications. Indeed, galactomannan from fenugreek seeds has garnered significant attention from research…

Bo Long, Liangchen Li, Xiaoqiang Liu

pp. 1499–1507 · DOI: 10.5530/ijper.20260554 · 2026

Objectives: This study evaluates the therapeutic effect of quercetin on Sepsis-related Acute Kidney Injury (S-AKI) and explores its potential mechanisms to provide theoretical support for its use in treating S-AKI. Mater…

Yingda Yan, Fanwen Yang

pp. 1515–1522 · DOI: 10.5530/ijper.20260555 · 2026

Objectives: Our study aims to explore the effect of Ginkgo biloba Leaf extracts (GBLF) on diabetic nephropathy and its mechanism. Materials and Methods: Fifty rats were divided into five groups: Control, Model, Positive …

Yanping Li, Feng Li, Weiwei Zhuo, Xiaomeng Zhang, Hongjie Wu, Lihu Zhang

pp. 1523–1531 · DOI: 10.5530/ijper.20262414 · 2026

Aim/Background: This study aims to develop an AI-enhanced virtual lab framework. It addresses the high costs and operational risks of traditional biopharmaceutical fermentation engineering education. The proposed solutio…

Zhen He, Gang Chen, Jianghua Li

pp. 1532–1538 · DOI: 10.5530/ijper.20260673 · 2026

Objectives: To explore the effect of total alkaloids of Tripterygium wilfordii (TAPC) on Alzheimer's Disease (AD) in mice through antioxidation, anti-neuronal apoptosis and anti-neuroinflammation. Materials and Methods: …

Haiwei Xiong, Xiaoyan Nie, Jiahui Wu, Wei Cao

pp. 1539–1543 · DOI: 10.5530/ijper.20260679 · 2026

Objectives: To investigate the inhibitory effect of Echinacoside on the malignant biological behavior of breast cancer cells through the regulation of the Lymphatic Enhancement Factor 1 (LEF1)-Cell Surface Adhesion molec…

Poh Yen Thong, Chean Hui Ng, Ke-Xin Yu, Samer Al-Dhalli, Mohamad Nizam Abdul Ghani, Siaw Fui Kiew, Sie Yon Lau, Chin Siang Kue

pp. 1544–1554 · DOI: 10.5530/ijper.20261692 · 2026

Background: Peel extract of Citrus sinensis is rich in beneficial phytochemicals that can protect the skin from the harmful effects of UV radiation. This study evaluates the suitability of C. sinensis peel waste as the p…

Changqing Li, Junpeng Meng

pp. 1555–1563 · DOI: 10.5530/ijper.20261510 · 2026

Background: Ischemic Stroke (IS) is a serious illness with great fatality and disability globally. The pathophysiological causes of IS are oxidative stress, apoptosis and neuroinflammation. Objectives: Cerebral Ischemia/…