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Indian Journal of Pharmaceutical Education and ResearchNOW IN
Article

Neuroprotective Effect of Stemona tuberose Leaf Extract on MCAO/R-Induced Rats via P13K/Akt Signaling Pathway

Changqing Li1, Junpeng Meng2★★ Corresponding author

  1. 1Department Four of Brain Disease, Xi’an TCM Hospital of Encephalopathy, Xi’an, CHINA.
  2. 2Department of Neurology, Northwest University First Hospital, Xi’an, CHINA.

CORRESPONDENCE

Junpeng Meng

Department of Neurology, Northwest University First Hospital, Xi’an, CHINA.

1037805120mjp@sina.com

Received: 17-04-2025; Revised: 09-06-2025; Accepted: 26-08-2025.

Volume 60, Issue 4 · pp. 1555–1563 · PUBLISHED 2026 · DOI: 10.5530/ijper.20261510

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ABSTRACT

Background: Ischemic Stroke (IS) is a serious illness with great fatality and disability globally. The pathophysiological causes of IS are oxidative stress, apoptosis and neuroinflammation. Objectives: Cerebral Ischemia/Reperfusion Injury (CI/RI) is arecurrent pathological development resulting in IS. Stemona tuberose (ST), which comes under the Stemonaceae family, has been extensively involved in Chinese traditional medication to treat inflammatory disorders. Materials and Methods: The current study investigated this medicinal herbs Stemona tuberose leaf extract (STLE) for the first time concerning its neuroprotective activity inthe CI/RI ratsdeveloped by the MCAO/R technique. Rats were distributed into 5 sets; sham, MCAO/R-induced, MCAO/ R+STLE (25 mg/kg bw), MCAO/R + STLE (50 mg/kg bw) and MCAO/R+STLE (100 mg/kg bw). CI/RI triggered cerebral injury was evaluated using infarction volume, oxidative stress, histopathology, microglial polarization, neuroinflammation and apoptosis. Results: STLE could dose-dependably alleviate infarction volume, oxidative stress, histopathological changes, neuroinflammation and apoptosis while enhancing microglia/macrophages M1/M2 polarization in CI/RI rats. STLE exerts anti-apoptotic properties by the augmented Bcl-2/Bax proportion and diminished caspase-3 levels. STLE could modulate the microglia polarization from the phenotype M1 pro-inflammatory to the M2 anti-inflammatory potential. Conclusion: Furthermore, STLE showed promise in reducing CI/RI-induced apoptosis by modulating the P13K/Akt signaling pathway. These results demonstrate STLE's therapeutic promise in the management of ischemic stroke and associated neuroinflammatory diseases.

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    Li, C., & Meng, J. (2026). Neuroprotective Effect of Stemona tuberose Leaf Extract on MCAO/R-Induced Rats via P13K/Akt Signaling Pathway. Indian Journal of Pharmaceutical Education and Research, 60(4), 1555–1563. https://doi.org/10.5530/ijper.20261510