Article · Volume 50, Issue 3 · pp. 368–375

Anthocyanin Improving Metabolic Disorders in Obese Mice from Aornia melanocarpa

Jie Wei¹, Guokun Zhang¹, Xiao Zhang¹, Jun gao², Jungang Fan², Zhiquan Zhou²

¹School of Life Science, Liaoning University, Shenyang 110036, CHINA.
²Foresty Science Research Institute of Liaoning Province, Shenyang, CHINA.

Abstract

The aim of this study was to investigate the effects of Aornia melanocarpa anthocyanin (AMA) on symptoms of metabolic syndrome in obese mouse. AMA can reduce weight. Blood glucose and lipid metabolism were significantly improved, and so as hepatic lipid metabolism. This suggesting AMA is a strong indication of improved glucose lipid metabolism and weight. Moreover, both morphologic and histological detections indicated that AMA significantly reversed obsity induced hepatic steatosis and liver injury. Furthermore, AMA significantly ameliorated inflammatory cytokines including both IL-6 and TNF-α in liver and fatty tissue. Moreover, insulin receptor (IR), p-IRS and p-AKT that associated proteins about glucose-lipid metabolism signaling pathway were markedly up-regulated at protein levels by AMA. Our results demonstrate that Aornia melanocarpa anthocyanin treatment can alleviate obsity and metabolic syndrome. The beneficial effects of AMA are associated with improved glucose-lipid metabolism and reduced levels of inflammatory cytokines.

Keywords: Metabolic disorders; Obese; Aornia melanocarpa; Anthocyanin; Mechnism

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