Article · Volume 51, Issue 3 · pp. 490–501
Synthesis, Characterization and Antimicrobial Activity of some Metal Complexes Derived from Thiazole Schiff Bases with In-vitro Cytotoxicity and DNA Cleavage Studies
Shambuling Karabasannavar1,2, Parvati Allolli3, Irfan N. Shaikh4, Basavaraj M. Kalshetty5
- 1R & D centre, Bharathiar University, Coimbatore. Tamilnadu, INDIA.
- 2Department of Chemistry, BGMIT Mudhol, Karnataka, INDIA.
- 3Department of Pharmaceutical chemistry, Karnataka State Women University, Bijapur. Karnataka, INDIA.
- 4Department of Chemistry, SECAB Institute of Engineering & Technology, Vijayapur, Karnataka, INDIA.
- 5Department of chemistry, BLDE’s Science College Jamkhandi, Bagalkoti, Karnataka, INDIA.
Abstract
Five metal complexes with Schiff-base ligand, 3-((4-phenylthiazol-2-ylimino) methyl)-2- hydroxybenzoic acid were synthesized with metal ions such as Cu(II), Co(II), Ni(II), Cd(II) and Zn(II). The reaction likely proceeds via condensation of 2-amino-4-phenyl thiazole with 3-aldehydosalicylic acid and characterized by elemental analysis and various spectral studies like FT-IR, 1H NMR, ESI mass, and TGA/TDA and molar conductance studies. The spectral results revealed bidentate O-O donor and forms the complexes having square planar geometry. The antibacterial and antifungal activity of the ligand and its metal complexes was found based on the determination of minimum inhibitory concentrations. The brine shrimp biological assay was also carry out to study the In vitro cytotoxicity properties for the ligand and its metal complexes against Artemia salina. Moreover, DNA cleavage experiments revealed that the Cu (II), Co (II) and Zn (II) complexes exhibited remarkable DNA cleavage activities via the generation of hydroxyl radical.
Keywords: Thiazole; Schiff base; Antimicrobial; DNA cleavage; In-vitro cytotoxicity
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