Review · Volume 53, Issue 2S · pp. s1–s16

Recent Developments on Pharmacological Potential of 1,3,4-Oxadiazole Scaffold

Bhutani Rubina¹, Pathak Dharam P¹, Kapoor Garima¹, Kant Ravi¹, Dutta Manni²

¹Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, New Delhi, INDIA.
²School of Medical and Allied Sciences, GD Goenka University, Gurgaon, Haryana, INDIA.

Abstract

Heterocyclic compounds represent the important structural key in pharmaceutical medicinal chemistry. In literature, five-membered heterocycles are reported to be a core moiety of various pharmaceutical drugs. 1,3,4-oxadiazole scaffold, among various five-membered heterocycles is an important molecule which attracts various medicinal chemist to develop a novel biologically active molecule. 1,3,4-Oxadiazole is found to bear important pharmacological activities such as anti-diabetic, antimicrobial, anti-cancer, anticonvulsant, antioxidant, anti-Alzheimer’s, anti-inflammatory, antiviral, cardiovascular, anti-tuberculosis, anti-pyretic, insecticidal. This review compiles the biological updates on various compounds containing 1,3,4-oxadiazole as a core moiety from the recent years.

Keywords: Anti-diabetic; Anti-cancer; Heterocycle; Oxadiazole; Pharmacological activity

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