Review · Volume 53, Issue 2S · pp. s28–s42

Sesamol and Health – A Comprehensive Review

Abhishek Shah¹, Richard Lobo¹, Nandakumar Krishnadas², Raviteja Surubhotla³

¹Departments of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy for Higher Education, Manipal.
²Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy for Higher Education, Manipal.
³Department of Pharmacology, Sai Life Sciences Limited, Pune, Maharashtra, INDIA.

Abstract

Antioxidant potential of sesamol has led to being studied extensively in recent decades for its beneficial role in vast aliments. There has been a renewed interest in this compound recently, due to its activities such as hepatoprotective, neuroprotective, chemopreventive, anti-inflammatory, cardioprotective, skin protective and antiaging properties which were established in various preclinical models. Further studies may be required to develop its underlying mechanisms and to investigate its various biological activities to develop an optimal dose range. Hence, a comprehensive review is necessary on in vivo and in vitro activities of sesamol. This review is to highlight the potential of sesamol as a potent therapeutic agent for humans.

Keywords: In vitro; in vivo studies; Pharmacokinetics; Sesamol; Synthesis

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