Skin Targeting Approaches in Cosmetics

Abstract

Objective: To emphasize and summarize the main component of skin and approaches to target them.Methods: Skin targeting approaches in cosmetics is a review of all the relevant papers known to the author was conducted.Results: The exhaustive review on the basis of the previously reported paper revealed that the skin is a complicated and intact structure having vast of targeting component such as Keratin, Elastin fibres, ECM, MMPs, collagen, Hyaluronic Acid etc and apart from that the receptor and signalling pathway mediated skin targeting is also a promising approach to deliver bioactive at specific site of skin by the help of Surface engineered nanocarriers. Receptors like Epidermal Growth Factor Receptor (EGFr), interleukin-1 receptor (IL-1r), Tumor Necrosis Factor Receptor (TNFr), Platelet-Derived Growth Factor Receptor (PDGFr) and PlateletActivating Factor Receptor (PAF-r) are the types of receptor present in skin cells. These receptors are targeted by nanocarriers which are surface engineered by conjugating them ligands which show the specific affinity towards receptor present in the skin cells.

Keywords: Skin; Targeting; ECM; MMPs; Collagen; EGFr; IL-1r; TNFr; PDGFr; PAF-r; Nanocarriers