jrnls.org logo
Submit

BROWSE ALL JOURNALS

Type 2 letters to search all 19 journals

SEE ALL 19 JOURNALS
Indian Journal of Pharmaceutical Education and ResearchNOW IN
Back

IJPER · Lens · In vitro Anthelmintic Impact of Various Extracts of Pavetta tomentosa Root on Pheretima posthuma and in-silico Molecular Docking Evaluation of some Isolated Phytoconstituents

PDF

Article · Volume 54, Issue 2S · pp. s251–s260

In vitro Anthelmintic Impact of Various Extracts of Pavetta tomentosa Root on Pheretima posthuma and in-silico Molecular Docking Evaluation of some Isolated Phytoconstituents

Dintakurthi Sree Naga Bala Krishna Prasanth1, Siva Prasad Panda2, Atmakuri Lakshmana Rao3, Nayudu Teja4, Veenam Bhavya Naga Vani3, Tera Sandhya5, Pathange Bharghava Bhushan Rao4

  1. 1Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.
  2. 2Pharmacology Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.
  3. 3Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Krishna, Andhra Pradesh, INDIA.
  4. 4Department of Pharmaceutics, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Krishna, Andhra Pradesh, INDIA.
  5. 5Department of Pharmacology, Institute of Pharmaceutical technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, INDIA.

Abstract

Background: The current study assesses the anthelmintic impact of root extracts of Pavetta tomentosa on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the β-Tubulin (PDB ID: 1SA0).Methods: In this study, P. tomentosa root was subjected to extraction using methanol and water. In vitro, anthelmintic activity was assessed by utilizing the Pheretima posthuma and in silico molecular docking was executed making use of Autodock 4.0.Results: The outcomes revealed that the methanolic extract has the most significant dose-dependent anthelmintic activity at various doses, followed by aqueous extracts of root. Amongst all the substances, β-eudesmol revealed the most effective docking rating of -6.53, which is nearer to Albendazole, i.e., -6.79, ensuring that β-eudesmol has a strong binding fondness in between protein and ligand.Conclusion: From the examinations, a conclusion can be drawn that the anthelmintic activity of P. tomentosa root in both in vitro and insilico assays. The information sustains β-eudesmol to be a useful anthelmintic compound beneficial to future clinical examinations.

Keywords: In-silico; Autodock 4.0; Pavetta tomentosa; β-eudesmol; Albendazole; ADME/T

The full text of this article is available as a PDF. Open the PDF.