Article · Volume 54, Issue 3S · pp. s580–s585

Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide

Muhammad Torequl Islam^1,2

¹Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.
²Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.

Abstract

Background: Andrographis paniculata and its main components andrographolide (AGL) have been reported for their promising cardio-protective effects in experimental animals.Aim: To investigate clot lysis activity of A. paniculata and AGL.Materials and Methods: The clot lysis activity of the aqueous A. paniculata stem extract (AAP) and AGL was investigated on clotted human blood by using streptokinase (SKE) as a standard drug.Results: Both AAP and AGL showed a concentration-dependent clot lysis activity. AAP showed the highest clot lysis activity at 100 μL (eq. 10% w/v) (54.12 ± 1.22%), while AGL showed at 100 μg/mL (58.62 ± 2.02%). The half maximal effective concentration (EC50) values of AAP and AGL were 87.32 ± 0.37 μL (eq. 8.732% w/v) and 79.74 ± 0.31 μg/mL, respectively. The netagive controls showed negligible clot lysis capacities, while the standard SKE showed 81.54 ± 0.78% clot lysis activity.Conclusion: AAP and its pure component NGL exhibited significant clot lysis activity on human clotted blood and may be good candidates for the treatment of atherothrombosis.

Keywords: Andrographis paniculata; Aqueous extract; Andrographolide; Atherothrombosis; Human blood

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