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IJPER · Lens · Development and Characterization of Leuprolide Acetate Encapsulated PLGA Microspheres for Parenteral Controlled Release Depot Injection

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Article · Volume 55, Issue 1 · pp. 107–116

Development and Characterization of Leuprolide Acetate Encapsulated PLGA Microspheres for Parenteral Controlled Release Depot Injection

Soumya Ranjan Satapathy1, Rudra Narayan Sahoo1,2, Biswaranjan Satapathy3, Ramachandrarao Immani4, Lalatendu Panigrahi5, Subrata Mallick1

  1. 1School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA.
  2. 2School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, INDIA.
  3. 3Orbicular Technologies Pvt Ltd, Mumbai, Maharashtra, INDIA.
  4. 4Department of Chemistry, Annamalai University, Chidambaram, Tamil Nadu, INDIA.
  5. 5Encube Ethicals Pvt Ltd, Mumbai, Maharashtra, INDIA.

Abstract

Objectives: Polylactic acid (PLA) and copolymer polylactic-co-glycolic acid (PLGA) are the most versatile drug carriers for long acting release injectable (LAI) formulations for small molecules, peptides and macromolecules such as proteins and nucleic acids. The present research work consists of a PLGA based one-month release microsphere formulation of GnRH agonist leuprolide acetate, using double emulsion (W1/O/W2) technique.Materials and Methods: Microparticles were prepared by double emulsion solvent evaporation technique and critical quality attributes of finished products such as drug loading, entrapment efficiency, particle size distribution (PSD), surface porosity, drug distribution within microparticles were analysed. Results and Conclusion: The microspheres have shown the mean particle size of 15.2 μm and suitable particle size distribution pattern ideal for syringe ability. The microparticles were spherical in shape with uniform pore distribution and uniform distribution of API in the polymer matrix. The drug release has been sustained over a month for the microsphere formulation and could be correlated with the testosterone suppression.

Keywords: Leuprolide; PLGA Microspheres; Double-emulsion technique; Prostate cancer; Controlled release depot Injection

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