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IJPER · Lens · Doxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity

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Article · Volume 55, Issue 1 · pp. 117–125

Doxorubicin Hydrochloride Loaded Polyanhydride Nanoformulations and Cytotoxicity

Nagaraja Sreeharsha1,2, Jagadeesh G Hiremath3, Prashanth Kumar R4, Girish Meravanige5, Saleemulla Khan6, Ranjith Kumar Karnati7, Mahesh Attimarad1, Bandar Al-Dhubiab1, Anroop Balachandran Nair1, Katharigatta Narayanaswamy Venugopala1,8

  1. 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  2. 2Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.
  3. 3Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, India.
  4. 4Department of Pharmaceutics, East West College of Pharmacy, Bangalore, Karnataka, INDIA.
  5. 5Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  6. 6Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
  7. 7Department of Chemistry, College of Science, King Faisal University, Hofuf, SAUDI ARABIA.
  8. 8Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.

Abstract

This study aimed to evaluate DOX∙HCl loaded P(DLLA-CO:60:40) nanoformulations with a copolymer of F127 as a potential drug delivery system for cancer. DOX ∙ HCl was encapsulated in nanoformulations of Poly DL-lactic acid co castor oil 60:40, P(DLLACO: 60:40) polymer with the copolymer/stabilizer Pluronic® F127. The mean diameter of the cylindrical rod shape of the nanoformulation particles was 248±2.4-260±3.2 nm with an acceptable poly dispersibility of 0.29- 0.33 and a smooth surface as visualized by DSC, SEM and XRD displayed that DOX∙HCl was present as an disordered crystalline or amorphous state in the nanoformulations. The nanoformulations showed a steady pattern of drug discharge for 24 hrs. F-3 and F-4 formulations had IC50 values of 3.2±0.03 and 1.98±0.08 mcg/ml while the free drug inhibition concentration of IC50 was 2.2 mcg/ml. The drug-loaded nanoformulations showed significant cytotoxic effects on MCF-7 breast cancer cell lines.

Keywords: Doxorubicin hydrochloride; MCF-7 breast cancer cell lines; Nanoformulations; Drug delivery

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