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IJPER · Lens · Anti-inflammatory and Anti-arthritic Activity of Rosmarinic acid Isolated from Rosmarinus officinalis in an Experimental Model of Arthritis

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Article · Volume 55, Issue 2 · pp. 507–516

Anti-inflammatory and Anti-arthritic Activity of Rosmarinic acid Isolated from Rosmarinus officinalis in an Experimental Model of Arthritis

Tianhu Wei1, Yuan Liu2, Meirong Li3

  1. 1Department of Bao’s Orthopedic, Inner Mongolia International Mongolian Hospital, Hohhot City, Inner Mongolia, CHINA.
  2. 2Department of Emergency, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, Zhengzhou City, Henan, CHINA.
  3. 3Department of Rheumatology, XuZhou Central Hospital, XuZhoucity, JiangSu Province, CHINA.

Abstract

Background: Rosmarinus officinalis L. (family Lamiaceae is a perennial herb or small woody evergreen tree, commonly known as rosemary, which is native to the Mediterranean and Asia and reasonably hardy in cool climates. It has been used as a decoction in traditional Unani and Swedish medicine for the treatment of inflammatory diseases.Aim: To isolate rosmarinic acid (RA) from R. officinalis. leaf extract and to evaluate its protective effects against Freund’s adjuvant-induced arthritis in rats.Materials and Methods: Arthritis was induced via sub-plantar injection of 1mg heat-killed Mycobacterium tuberculosis (complete Freund’s adjuvant, CFA) into the left hind paw of rats. The experiment was designed and optimized based on published methods.Results: At 60 mg/kg, the RA fraction of the methanolic extract of R. officinalis L. exerted potentially effective anti-arthritic effects by controlling inflammation in an adjuvant-induced experimental model.Conclusion: Considering experimental findings relating to pharmacological and biochemical parameters, we conclude that oral administration of the RA fraction (30 and 60 mg/kg) from the methanolic extract of R. officinalis L. exerts anti-arthritic effects and controls inflammation in an adjuvant-induced arthritis rat model. RA is therefore a promising plant-derived anti-arthritic agent for the treatment of inflammatory disorders.

Keywords: Freund’s adjuvant-induced arthritis; Rosmarinic acid; Rosmarinus officinalis L; Histopathology; Inflammation

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