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Indian Journal of Pharmaceutical Education and ResearchNOW IN
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IJPER · Lens · Protective Effects of Ficus benghalensis in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model

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Article · Volume 56, Issue 3 · pp. 822–829

Protective Effects of Ficus benghalensis in Streptozotocin (STZ) Induced Diabetic Zebrafish (Danio rerio) Model

Essa M Sabi1, Ahmed H Mujamammi1, Ziyad M Althafar2, Samia T Al-Shouli3, Lotfi S Bin Dahman4, Khalid M Sumaily1

  1. 1Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
  2. 2Department of Medical Laboratories Sciences, College of Applied Medical Sciences in Alquwayiyah, Shaqra University, Riyadh, SAUDI ARABIA.
  3. 3Immunology Unit, Pathology Department, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
  4. 4Department of Medical Biochemistry, College of Medicine and Health Sciences, Hadhramout University, Mukalla, YEMEN.

Abstract

Background: Diabetes Mellitus (DM) is a chronic metabolic disorder that is characterized by hyperglycemia. Severe complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy are associated with DM.Objectives: To explore a safer treatment option with no/less adverse effects, we evaluated the potential of Ficus benghalensis to alleviate certain diabetic conditions.Materials and Methods: Administering streptozotocin to zebrafish intraperitoneally induced diabetes. After induction, Ficus benghalensis hydroethanolic bark extract was administered to zebrafish in different concentrations (5, 10, and 15 μg/mL). Biochemical blood parameters such as Blood Glucose, total cholesterol levels, triglycerides, and liver enzymes such as alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase were analyzed.Results: Treating the streptozotocin-induced group with Ficus benghalensis hydroethanolic bark had a hypoglycemic effect and reduced the cholesterol, triglycerides, and liver enzymes. The histopathological evaluation also showed improvement in the damaged pancreatic tissues.Conclusion: Our results suggest that Ficus benghalensis hydroethanolic bark extract can be used as a potent therapeutic candidate for treating diabetes.

Keywords: Diabetes mellitus; Ficus benghalensis; Alkaline phosphatase; Alanine; aminotransferase; Aspartate aminotransferase; Zebrafish

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