Mucoadhesive Films of Liquorice and Chlorhexidine Gluconate for Treating Mouth Ulcers

Abstract

Objectives: Mouth ulcer is a rupture or breaks in the oral mucosal membrane and it leads to atrophy and ulcers in the oral cavity. It increases the risk of infections with the Candida species Inherited trauma and aphthous stomatitis, a disorder characterised by the recurrent production of oral ulcers for unknown reasons, are the most common causes of oral ulceration. Study Design: This study aimed to develop two separates buccal mucoadhesive films, using model drug deglycyrrhizinated liquorice and chlorhexidine gluconate. The film was assessed for weight, thickness, pH, folding endurance, swelling index, mucoadhesive force, % moisture content, drug uniformity, in vitro release of drug, anti-microbial effect including anti-inflammatory activity and scanning electron microscopy. The developed formulations we re-evaluated for surface pH, folding endurance, swelling index, mucoadhesive force, and percentage moisture loss. Results and Conclusion: The results showed that the developed oral films were having good anti-inflammatory activity with an anti-microbial effect.

Keywords: Deglycyrrhizinated liquorice; Chlorhexidine gluconate; Mucoadhesive buccal films; Anti-inflammatory activity