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IJPER · Lens · Toxicological Study of n-hexane and Chloroform Extracts of Lantana camara L. in Experimental Animals

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Article · Volume 57, Issue 2S · pp. s370–s380

Toxicological Study of n-hexane and Chloroform Extracts of Lantana camara L. in Experimental Animals

Sribatsa Lanchhana Dash1, Ranjit Mohapatra1, Suman Kumar Mekap1,2, Smruti Ranjan Masanta3, Arpit Katiyar4, Nitin Sharma5, Ritu Karwasra6, Sagar Kumar Mishra1

  1. 1Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Odisha, INDIA.
  2. 2Department of Pharmacy, Centurion University of Technology and Management, Bhubaneswar, Odisha, INDIA.
  3. 3School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, INDIA.
  4. 4Sai Meer College of Pharmacy, Chhibramau, Kannauj, Uttar Pradesh, INDIA.
  5. 5Department of Pharmaceutics, ISF College of Pharmacy, Ghal Kalan, Moga, Punjab, INDIA.
  6. 6Central Council for Research in Unani Medicine, Ministry of AYUSH, Janakpuri, New Delhi, INDIA.

Abstract

Aim: The aim of the current study is to investigate the acute, sub-acute and sub-chronic toxicity study of extracts (n-hexane and chloroform) of L. camara in Wistar rats.Materials and Methods: HPTLC and GC-MS analysis were carried out to analyze different constituents present in L. camara extract. Acute toxicity study was conducted as per OECD 420 guidelines, while sub-acute and sub-chronic studies were conducted according to OECD 407 and 408 guidelines respectively. Toxicopathological effects of both extracts were tested with the help of hemotoxylin and eosin staining of vital organs (liver, kidney, brain, testes, and ovaries) in experimental animals. Antioxidant and behavioral tests were also conducted on both the extracts, so as to evaluate the possible effects of toxicity.Results: The toxicity investigation of chloroform and n-hexane extracts exhibits no toxicity in terms of hematological (p<0.01) and biochemical parameters (p<0.05). Histopathological sections also confirmed the non-toxic effects on the liver, brain, kidney and on reproductive organs.Conclusion: The n-hexane and chloroform extracts of L. camara can be safely used for therapeutic purposes.

Keywords: Lantana camara; GC-MS; HPTLC; Toxicity; Histopathology; Antioxidant; PI uptake

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