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IJPER · Lens · Nephroprotective Activity of Dibenzo-α-Pyrone Derivatives in Gentamicin-Induced Nephrotoxicity and Oxidative Stress in Rats

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Article · Volume 58, Issue 2 · pp. 618–623

Nephroprotective Activity of Dibenzo-α-Pyrone Derivatives in Gentamicin-Induced Nephrotoxicity and Oxidative Stress in Rats

Shalini K. Sawhney1, Monika Singh2, Dinesh Puri3, Sangeeta Hazarika4, Achal Mishra5

  1. 1Department of Pharmaceutical Chemistry, ITS College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, INDIA.
  2. 2Department of Pharmacology, ITS College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, INDIA.
  3. 3Department of Pharmaceutics, School of Pharmacy, Graphic Era Hill University, Dehradun, Uttarakhand, INDIA.
  4. 4Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi.
  5. 5Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Shri Shankaracharya Technical Campus, Bhilai.

Abstract

Objectives: The current work was done to determine the curative and nephroprotective activities of the synthesized butylamine derivative of Dibenzo-α-Pyrone (DAP).Materials and Methods: The synthesised drug at a concentration of 10, 20, and 40 mg/kg p.o. was given as a single dose in Albino rats with Gentamicin-induced nephrotoxicity. The changes in body weight of animals, if any, were monitored. Biochemical markers like serum creatinine, blood urea, and BUN concentrations were investigated to detect nephrotoxicity. In the tissues of the kidney, Glutathione (GSH) and lipid peroxidation (MDA) were also assessed.Results: 40 mg/kg p.o. of synthesised butylamine derivative of Dibenzo-α-Pyrone (DAP) exhibited significant (p<0.001) nephroprotective activity in the experimental animals. The reduced body weight and augmented biochemical markers (blood urea, serum creatinine, BUN levels), which were the attributes of gentamicin administration, were altered by the test sample. An increase in GSH and a decrease in Malondialdehyde (MDA) production also proved the nephroprotective activity of the synthesized sample.Conclusion: The derivatives of Dibenzo-α-Pyrone (DAP) demonstrated nephroprotective activity in vivo. This study based on experimental evidence suggests the probable mechanism of nephroprotection of the test sample might be due to its antioxidant property.

Keywords: Dibenzo-α-pyrone; Gentamicin; Nephrotoxicity; Urea; Creatinine; Glutathione; Lipid; peroxidation

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