Design and Synthesis of Novel Series of Thiophene-2, 5-dicarbohydrazide Derivatives as Potential Anticancer Agents

Abstract

Background The biological activity of thiophene and carbohydrazide derivatives is well known; some of them are included in various anticancer drugs. Objectives The main goal of this work was to develop effective, effective and non-toxic compounds with anti-cancer properties. To achieve this goal, we synthesized a new series of N2, N5-bis(1E)- ethylidene thiophene-2,5-dicarbohydrazide derivatives. Materials and Methods Thiophene-2,5-dicarbohydrazide reacts with aromatic aldehydes and ethanol to form a new series of derivatives. This work examined the compounds obtained for them in vitro cytotoxic activity against the breast cancer lines MCF-7. Results The results of antiproliferative cell inhibition studies showed that some compounds showed high activities compared to standard imatinib drugs. Conclusion The most promising compounds D1-D10 were selected to study their inhibitory effects on the MCF-7 cell line, where compound D5 showed the highest activity. All synthesized compounds have no adverse effect on normal cell lines.

Keywords: Thiophene-2,5-dicarbohydrazide; Anticancer; MCF-7 cell lines; Derivatives