Article · Volume 59, Issue 1 · pp. 287–296

Effect of Evodiamine in the Prevention and Treatment of 5-FU Induced Diarrhea in Swiss Albino Rats: A Preliminary Study

Bianjiang He¹, Ke Su², Mingming Wei³, Guangya Zhou¹

¹Department of Traditional Chinese Medicine, Northwest University First Hospital, Xi’an, CHINA.
²Department of Dermatology, Northwest University First Hospital, Xi’an, CHINA.
³Department of Gynaecology, Northwest University First Hospital, Xi’an, CHINA.

Abstract

Aim of the Study To assess the antidiarrheal properties of Evodiamine in the prevention and treatment of Chemotherapy-Induced Diarrhea (CID) in experimental rats. Materials and Methods The Swiss albino female rats (8-12 weeks) rats were treated with Evodiamine for 13 days and 5-FU was administered on day 4 to day 10 (7 consecutive days) for the induction of diarrhea. After 13 days of experiments, all rats were euthanized and thymus and spleen weights were measured. Bodyweight and diarrhea rate and score were recorded every day. Results Our study resulted that Evodiamine significantly prevented and reduced the rate and intensity of diarrhea, body weight and thymus/spleen indexes in dose-dependently. The highest effects were observed with Evodiamine 50 and 100 mg/kg which exhibited a similar effect with that of loperamide (3 mg/kg). Conclusion Our findings demonstrated the antidiarrheal activity of Evodiamine for the prevention of 5-FU induced diarrhea. This is the first-ever study reporting on the antidiarrheal potential of Evodiamine against chemotherapy-induced diarrhea.

Keywords: Evodiamine; Chemotherapy; Diarrhea; Phytomedicine; Swiss albino rat; in vivo

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