Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Window

Abstract

Aim Isocitrate lyase is the ancient glyoxylate cycle enzyme that catalyzes isocitrate cleavage into succinate and glyoxylate. The glyoxylate cycle is a key metabolic pathway as indicated by significant data on many host pathogens, which confirm the fundamental existence, in particular, causing life-threatening diseases, including tuberculosis. Objectives Mycobacterium tuberculosis Isocitrate lyase and other organisms, which express ICL, have attracted the attention of molecular biologists and medicinal chemists due to their indispensable role in normal cellular metabolic pathways and even resistance. Numerous studies that blocked genes expressing ICL and gene knockout in experimental animals indicated retarded growth. The origins of these inhibitor studies approaches are categorized into mycobacterial and non-mycobacterial Isocitrate lyases. Conclusion Nonetheless, these inhibitors can be either synthetic or natural, while in this study, the authors emphasize catalytic enzyme information of Isocitrate lyase.

Keywords: Isocitrate Lyases; Mycobacterium tuberculosis; Glyoxylate cycle; Krebs cycle