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Indian Journal of Pharmaceutical Education and ResearchNOW IN
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IJPER · Lens · Formulation and Evaluation of Simvastatin Loaded Nanostructured Lipid Carrier for Topical Drug Delivery

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Article · Volume 59, Issue 2S · pp. s414–s425

Formulation and Evaluation of Simvastatin Loaded Nanostructured Lipid Carrier for Topical Drug Delivery

Madhuri Desai1, Shalaka Dhanna2, Sujata Jadhav3, Akshada Koparde4, Akansha Dashwanat5, Rutuja Gharal1

  1. 1Department of Pharmaceutics, Krishna Vishwa Vidyapeeth, Krishna Institute of Pharmacy, Karad, Maharashtra., INDIA.
  2. 2Department of Pharmaceutics, P.E. S’s Modern College of Pharmacy, Nigdi, Pune, Maharashtra, INDIA.
  3. 3Department of Pharmacology, Krishna Vishwa Vidyapeeth, Krishna Institute of Medical Sciences, Karad, Maharashtra, INDIA.
  4. 4Department of Pharmaceutical Chemistry, Krishna Vishwa Vidyapeeth, Krishna Institute of Pharmacy, Karad, Maharashtra, INDIA.
  5. 5Department of Pharmaceutics, Krishna Institute of Pharmacy, Karad, Maharashtra, INDIA.

Abstract

Introduction: Simvastatin, a BCS II drug, has poor water solubility and low bioavailability. Nanostructured Lipid Carriers (NLCs) can enhance its bioavailability. This study investigates the potential of NLCs to improve simvastatin's bioavailability.Objectives: The primary objective was to enhance simvastatin's bioavailability by formulating it into NLCs using High-Speed Homogenization (HPH). The study also aimed to characterize the NLCs and evaluate their stability and irritation potential.Materials and Methods: Simvastatin-loaded NLCs were prepared with Compritol 888 ATO, oleic acid, linseed oil, Tween 80 and distilled water using high-speed homogenization. Characterization included FTIR, DSC and PXRD. The optimized batch (F-II) was assessed for entrapment efficiency, particle size, polydispersity index, zeta potential and drug content. Stability and irritation potential were evaluated following ICH guidelines and Primary Irritation Index (PII) assessment.Results: FTIR showed no drug-excipient interactions. XRD confirmed the amorphous nature of simvastatin in NLCs. The optimized batch (F-II) had 78% EE, 148.4 nm particle sizes, 0.369 PDI, -2.90 mV ZP and 89.6% drug content. Stability studies confirmed robustness and PII was 0.11, indicating negligible irritation.Conclusion: HPH successfully prepared simvastatin-loaded NLCs, significantly enhancing bioavailability with favorable %EE, particle size and drug content. The formulation was stable and showed minimal irritation potential, making NLCs optimistic techniques for improving the bioavailability of poorly soluble drugs like simvastatin.

Keywords: Nanostructured Lipid Carrier; High-Speed Homogenization; Compritol 888 ATO

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