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Indian Journal of Pharmaceutical Education and ResearchNOW IN
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IJPER · Lens · Effect of Ethanol Extract of Rosella Flower (Hibiscus sab- dariffa L.) on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1) in the Healing Process of Incision Wounds in White Wistar Rats

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Article · Volume 59, Issue 3S · pp. s921–s929

Effect of Ethanol Extract of Rosella Flower (Hibiscus sab- dariffa L.) on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1) in the Healing Process of Incision Wounds in White Wistar Rats

Ade Dwi Pratiwi1, Jekson Martiar Siahaan2, Endy Juli Anto4

  1. 1Medical Faculty, Masters Program in Biomedical Sciences, Universitas Methodist Indonesia, INDONESIA, INDONESIA.
  2. 2Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia, Medan, INDONESIA.
  3. 3Department of Molecular Biology, Masters Program in Biomedical Sciences, Faculty of Medicine, Universitas Methodist Indonesia, Medan, INDONESIA.
  4. 4Department of Parasitology and Immunology, Faculty of Medicine, Universitas Methodist Indonesia, Medan, INDONESIA.

Abstract

Background: This study investigated the effect of rosella flower petal (Hibiscus sabdariffa L.) ethanol extract gel on incision wound healing in a rat model of diabetes mellitus. Wounds are skin disorders that can be caused by internal or external factors. The wound healing process involves various growth factors, including Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1).Materials and Methods: This study used a posttest-only controlled group design with male Wistar rats as the research subjects. This study aimed to evaluate the effect of rosella flower petal ethanol extract gel on FGF-2 and MMP-1 levels, as well as collagen and fibroblast cell formation in the wound healing process.Results: Phytochemical screening results revealed the presence of flavonoids, alkaloids, saponins, phenols, and tannins in rosella extract. The results showed a significant difference (p<0.05) in FGF-2 levels between all research groups and significant difference (p<0.05) in MMP-1 levels.Conclusion: The group that received ethanol extract gel of rosella flower petals with a concentration of 12% showed a better increase in the formation of FGF-2, MMP-1, collagen, and fibroblast cells compared to the other groups

Keywords: Ethanol Extract Rosella Flower Petals; Incision Wounds; White rat; Wistar strain

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