Volume 10, Issue 4

Tehzeeb T, Dhanabalan D

pp. 417–422 · DOI: 10.5330/ijpi.2020.4.74 · 2020

Recent progress in drug discovery in past decades reduced the high level of pain experienced due to infectious diseases by humans. A significant impact has been made on developing novel antimicrobial agents but is failin…

Pitchaimuthu Pandian

pp. 423–429 · DOI: 10.5330/ijpi.2020.4.75 · 2020

Heparin is used as anticoagulant for long period and also other activities both experimentally and clinically. The heparin is prepared by many methods namely enzymatic hydrolysis, chemical hydrolysis by removing the anti…

Amit Vinayak Asati, Kishor Sahebrao Salunkhe, Machindra Jairam Chavan, Ravindra Bhausaheb Chintamani, Rudra Pratap Singh

pp. 430–436 · DOI: 10.5330/ijpi.2020.4.76 · 2020

Background: Solubility is an important physico-chemical factor affecting absorption of drug and its therapeutic effectiveness. One of the major problems responsible for the low turnout in the development of new molecular…

Ekramul Haque, Mohd Aamir Bin Riyaz, Sriram Shankar, Saqib Hassan

pp. 437–444 · DOI: 10.5330/ijpi.2020.4.77 · 2020

Objectives: The aim of this study was to isolate a potent biosurfactant producing bacterium and characterize the produced biosurfactant for its application in pharmaceutical, petrochemical, cosmetic and food industry. Me…

Johnson Stephin, Koland Marina

pp. 445–451 · DOI: 10.5330/ijpi.2020.4.78 · 2020

Introduction: Helicobacter pylori infection is strongly associated with chronic gastritis and duodenal ulcers which can benefit from gastro retentive delivery of clarithromycin. Objectives: The objective of this study wa…

S Agarwal, G Gautam

pp. 452–455 · DOI: 10.5330/ijpi.2020.4.79 · 2020

Background:The present investigation was held to develop vesicular ethosomal gel system for anti-hypertensive drug atorvastatin. Atorvastatin is a HMG-CoA reeducates inhibitor and utilized for minimizing cholesterol leve…

Prasad Suhas Kshirsagar, Darshana Sanjay Mote, Shriniwas Pramod Patil

pp. 456–459 · DOI: 10.5330/ijpi.2020.4.80 · 2020

Introduction:Andrographis paniculata is medicinal plant of family Acanthaceae, consists of bitter principles and traditionally used in treatment of several gastrointestinal diseases. To mask its bitter taste, it could be…

Garima Jain, Umesh K Patil

pp. 460–465 · DOI: 10.5330/ijpi.2020.4.81 · 2020

Objectives:The objective of the present study was to formulate, characterize and evaluate herbal formulations of Evolvulus alsinoides and Convolvulus pluricaulis against scopolamine-induced behavioral disturbances for Al…

Zoya Shprakh

pp. 466–470 · DOI: 10.5330/ijpi.2020.4.82 · 2020

Background: Nitrosoureas are chemotherapeutic alkylating agents, widely used in the treatment of malignant diseases. One of them (streptozotocin) is the standard for the therapy of neuroendocrine tumours. We synthesised …

Naseeb Basha Shaik, Divya Shakelli, Lakshmi PK, Basava Rao VV

pp. 471–478 · DOI: 10.5330/ijpi.2020.4.83 · 2020

Objectives: The objective of the present study was to improve the absorption of dolutegravir sodium by developing oral proliposomal formulation. Methods: Proliposomal formulations were prepared by film deposition on carr…

Pankaj Bhatt, Suruchi Singh, Satish Kumar Sharma, Sani Rabiu

pp. 479–485 · DOI: 10.5330/ijpi.2020.4.84 · 2020

Objectives:Aim of the present research work is to prepared rapid mouth dissolving film of frovatriptan Succinate. Methods: Rapid Dissolving Film is prepared by Solvent casting method, hydroxypropyl methylcellulose E3 and…

Rathna Kumarasamy, Padavala Navyaka, Ekramul Haque

pp. 486–491 · DOI: 10.5330/ijpi.2020.4.85 · 2020

Objectives:In this study, bioengineered AgNPs (silver nanoparticles) from Spirulina platensis was used to counter the biofilm mediated virulence by Vibrio parahemolyticus. Methods:AgNPs were synthesized from crude Spirul…

Amit Verma, Neetu Sachan, Kamla Pathak, Anurag Verma

pp. 492–499 · DOI: 10.5330/ijpi.2020.4.86 · 2020

Objectives: Natural polysaccharides are increasingly being used for diverse applications in drug delivery such as controlled release of drugs owing to their wide availability, renewability, biodegradability and biosafety…

Yeramanchi Sarah Sujitha, Yallamali Indira Muzib

pp. 500–505 · DOI: 10.5330/ijpi.2020.4.87 · 2020

Objectives:The objective of the present study was to increase the solubility of poorly soluble drug hesperidin and to increase the efficacy of the drug by loading hesperidin in emulsomal topical gel. Methods: Hesperidin …

Pathuri Raghuveer, Avula Prameela Rani

pp. 506–511 · DOI: 10.5330/ijpi.2020.4.88 · 2020

Aim: Self nano-emulsifying drug delivery system (SNEDDS) of candesartan cilexetil was explored to enhance its oral bioavailability. SNEDDS has tremendous potential in enhancing oral bioavailability of poorly aqueous solu…

Balamurugan Krishnan, Kirtimaya Mishra

pp. 512–518 · DOI: 10.5330/ijpi.2020.4.89 · 2020

Objectives: This paper portrays a recently developed, optimized and validated isocratic RP-HPLC strategy for the separation of two anti- diabetic drugs (sitagliptin and metformin) in bulk and pharmaceutical formulations …

İshak Erik, Gözde Kılıç, Sevde Seher Yaylı, Gülşah Yılmaz, Kamil Coşkunçelebi, Nurettin Yaylı

pp. 519–525 · 2020

Background:The present work was aimed to carry out volatile component analyzes in Vaccinium arctostaphlyos L., V. uliginosum L., V. vitis-idaea L. and V. myrtillus L leaf growing at different altitudes of the East Blacks…

Atchuta Ramakrishna Gudapati, Srinivasarao Pakalapati, Chidananda Swamy Rumalla, Benarji Patrudu Tammina

pp. 526–530 · DOI: 10.5330/ijpi.2020.4.91 · 2020

Objectives: Analytical methods are necessary for the field of pharmaceuticals to discover the drug, determination of drugs and metabolites in biological matrices. The present study aimed to develop liquid chromatography-…

Rama Kumar Kandula, Raja Sundararajan

pp. 531–536 · DOI: 10.5330/ijpi.2020.4.92 · 2020

Objectives: Helicobacter pylori infections are liable for most of the ulcers in the stomach and small intestinal. Talicia capsules was approved to be prescribed for the Helicobacter pylori infections. These capsules have…

HK Sundeep Kumar, Sujit Kumar Sahu, Jitendra Debata

pp. 537–541 · DOI: 10.5330/ijpi.2020.4.93 · 2020

Objectives: To develop a novel ultra-performance liquid chromatographic technique for the estimation of alectinib in a API and tablet. Methods: The chromatographic separation was achieved using DIKMA Endoversil (2.1 x 50…