Evaluation of Classical Ayurvedic Medicine for its Neuropharmacological Action

Abstract

Background: The classical ayurvedic formulation Bru-satavari after consumption by people can get a restful night's sleep and feel rejuvenated. The goal of this study is to look at important phytoconstituents which may influence the neuropharmacological activities. Therefore, we made an effort to learn the methanol extract of classical ayurvedic formulation Bru-Satabari having anyneuropharmacological activity.Materials and Methods: The open field, hole cross, rota-rod, and thiopental sodium-induced sleeping duration tests on mice were used to examine the sedative effect of brusatavari at dosages of 400 mg/kg. The anxiety-relieving effect evaluated using the hole-board test. Compared to the positive control drug diazepam, sedative and anxiolytic effects were seen. Analgesic effect was evaluated by tail flick method.Results: According to the study, the extract has remarkable neuropharmacological action because it lowers mice's anxiety and locomotor activity in all instances of hole cross, open field, and rota rot tests when compared to the control. Additionally, compared to the standard and control group, the extract extends sleep time with a rapid onset of effect. Further the Bru-satavari exhibited excellent analgesic activity in comparison to control.Conclusion: The findings confirm the use of Bru-Satabari in traditional medicine by showing that it exhibits sedative and anxiolytic properties. Best suggested: More research into the drug's mechanism of action and the isolation of its active compounds.

Keywords: Bru-Satabari Sedative; Anxiolytic; Thiopental sodium-induced sleeping test; Neuropharmacology