Evaluation of Classical Ayurvedic Medicine for its Neuropharmacological Action
Sujit Dash1★, Amaresh Chandra Sahoo2, Prabhat Kumar Sahoo2, Sushanta Kumar Rout3, Pratik Jena1, Rajlaxmi Barik1, Jyotiraditya Mohapatra1★ Corresponding author
- 1Department of Pharmacognosy, Institute of Pharmacy and Technology, Salipur, Odisha, INDIA.
- 2Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Odisha, INDIA.
- 3Department of Science and Technology, Government of Odisha, Odisha, INDIA.
CORRESPONDENCE
Sujit Dash
Department of Pharmacognosy, Institute of Pharmacy and Technology, Salipur, Odisha, INDIA.
Received: 21-12-2022; Revised: 17-02-2023; Accepted: 30-03-2023.
Volume 13, Issue 3 · pp. 503–511 · PUBLISHED · DOI: 10.5530/ijpi.13.3.062
ABSTRACT
Background: The classical ayurvedic formulation Bru-satavari after consumption by people can get a restful night's sleep and feel rejuvenated. The goal of this study is to look at important phytoconstituents which may influence the neuropharmacological activities. Therefore, we made an effort to learn the methanol extract of classical ayurvedic formulation Bru-Satabari having anyneuropharmacological activity. Materials and Methods: The open field, hole cross, rota-rod, and thiopental sodium-induced sleeping duration tests on mice were used to examine the sedative effect of brusatavari at dosages of 400 mg/kg. The anxiety-relieving effect evaluated using the hole-board test. Compared to the positive control drug diazepam, sedative and anxiolytic effects were seen. Analgesic effect was evaluated by tail flick method. Results:According to the study, the extract has remarkable neuropharmacological action because it lowers mice's anxiety and locomotor activity in all instances of hole cross, open field, and rota rot tests when compared to the control. Additionally, compared to the standard and control group, the extract extends sleep time with a rapid onset of effect. Further the Bru-satavari exhibited excellent analgesic activity in comparison to control. Conclusion: The findings confirm the use of Bru-Satabari in traditional medicine by showing that it exhibits sedative and anxiolytic properties. Best suggested: More research into the drug's mechanism of action and the isolation of its active compounds.
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Dash, S., Sahoo, A. C., Sahoo, P. K., Rout, S. K., Jena, P., Barik, R., & Mohapatra, J. (). Evaluation of Classical Ayurvedic Medicine for its Neuropharmacological Action. International Journal of Pharmaceutical Investigation, 13(3), 503–511. https://doi.org/10.5530/ijpi.13.3.062