Volume 13, Issue 3

· pp. 367–679 · 38 articles

Volume: 13
Issue: 3
Published
Pages: 367–679
Articles: 38
Sections: 2
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article

In this issue

Review Article

Review
Past Work Done on the Matrix Tablets: A Quick Reference for the Research Beginner in Sustained-release Dosage Forms
Hindustan Abdul Ahad, Haranath Chinthaginjala, Bake Meharajunnisa, Nayakam Vandana, Renuka Gudisipalli, Peddapothula Nikhila
pp. 367–372 · DOI: 10.5530/ijpi.13.3.047 · Published
Matrix tablets are also referred to as sustained-release, controlled-release, or prolonged-release extended-release tablets, which will prolong the duration of the release of drug content into the systemic circulation. T…
Review
Overview on Evolving Variants of Novel Coronavirus and Control Measures in India
Prerana P, Jeyasree M G, Sumitha R
pp. 373–380 · DOI: 10.5530/ijpi.13.3.048 · Published
The new coronavirus has spread to more than 200 nations since it first appeared in China in December 2019. Worldwide, there have been more than 58.3 billion confirmed cases of the coronavirus and more than 64.2 lakh fata…
Review
An Overview of the Various Appropriate Types of Cell Lines for the Production of Monoclonal Antibodies
Shahin Javanmard
pp. 381–392 · DOI: 10.5530/ijpi.13.3.049 · Published
As the first monoclonal antibodies [mAbs] were produced in 1975, the challenge to improve antibody engineering started. Since then, therapeutic antibodies have become the predominant class of new drugs developed recently…
Review
Ashwagandha: A Flagship Herb of Ayurveda from Past to Present Nano Era
Shefali Arora, Krishna Samanta, Sukanya Chettri, Devendra Rawat, Versha Percha, Deepak Kumar
pp. 393–401 · DOI: 10.5530/ijpi.13.3.050 · Published
Plants are considered excellent resources for the generation of greener biomaterials. Plant extract are renewable in nature. Various metabolites present in plant extract are normally used in redox reaction for the format…
Review
Biosensors - An Insight into the Electrochemical and Optical Biosensors
Sri Nataraj Kalakonda, Rani Bammidi, Harika Edubilli, Sangeetha Medapati, Sahantha Lakshmi Deepthi Boyina, V V S Rajendra Prasad
pp. 402–412 · DOI: 10.5530/ijpi.13.3.051 · Published
The upgrading of useful biosensors having advantages in disease monitoring besides detection has been sped up by the demand for quick, cheap, portable, easy screening procedures. Bioanalytical devices such as Biosensors …
Review
Regulatory Outlook on Patient Reported Outcome Measures: Appraising Patients’ Voices to Approach People-Centered Model of Health Care
Anjali Nair, Madhugiri Prakash Venkatesh
pp. 413–421 · DOI: 10.5530/ijpi.13.3.052 · Published
Health systems attempt to measure an ever-increasing number of clinical measures when it’s about providing the best treatment to patients. Historically, agencies relied on lab tests such as blood panels and urine analysi…
Review
The Phytochemical and Pharmacological Effects of Hibiscus rosa-sinensis: A Review
Ezza Izzati Zulkurnain, Salfarina Ramli, Aida Azlina Ali, Richard Johari James, Ihsan Safwan Kamarazaman, Hasseri Halim
pp. 422–431 · DOI: 10.5530/ijpi.13.3.053 · Published
Medicinal plants play important roles in the treatment of various diseases. The aim of this review is to compile and document the phytochemical properties and the pharmacological effect in different parts of the various …
Review
Bridging the Gap: Aligning GMP Requirements for Generic Manufacturing across the US, EU and Japan
Jayant Kumar, Ajmera Ramkishan, Madhugiri Prakash Venkatesh
pp. 432–439 · DOI: 10.5530/ijpi.13.3.054 · Published
Medications that are no longer covered by a patent and that are made by companies other than the original inventor are known as generics. In recent years, the use of generic medications has grown, principally as a cost-c…
Review
How Generic Drugs are Registered in Europe, United Kingdom, Australia and New Zealand? - A Drug Regulatory Perspective
Sandeep DS, Lavanya YK, Shailesh T
pp. 440–445 · DOI: 10.5530/ijpi.13.3.055 · Published
The present study describes the process of regulatory submission and generic drug registration in Europe, the UK, Australia, and New Zealand. The information and data for the compilation of the present review has been ob…
Review
Concept of Abdaal e-Advia (Therapeutic Interchange) in the Light of “Maqala Fi- Abdal Al- Adwiya Al- Maustamala Fi -Al -Tib Wa Al- Ilaj” Known as “Kitab Al- Abd
Shaista Perveen, Abdul Wadud, Ghulamuddin Sofi, Aisha Perveen
pp. 446–454 · DOI: 10.5530/ijpi.13.3.056 · Published
Background and Objectives:Unani Medicine is mainly based on the drugs collected from plant sources. These drugs are time-tested, but their availability has become a challenge. Rapid industrialization and overpopulation h…
Review
Dental Pulp Stem Cells: Biology and Promise for Regenerative Medicine
Alhanouf Binhezaim, Tahani Almutairi
pp. 455–471 · DOI: 10.5530/ijpi.13.3.057 · Published
Dental Pulp Stem Cells (DPSCs) offer great potential in regenerative medicine. Odontoblasts are naturally occurring cells that are responsible for constructing dentin for restorative dental purposes. Yet, their potential…

Original Article

Article
Impact of Mobile Radiations on Gliclazide Tablet Formulation
Mukesh Tatyarao Mohite, Pankaj Sharma, Jaya Sharma, Pallavi Chaudhari, Sagar Kore
pp. 471–475 · DOI: 10.5530/ijpi.13.3.058 · Published
Introduction:Mobile radiation, also known as non-ionizing radiation, has been shown to have an impact on the formulation of Gliclazide tablets. The study’s objective was to examine the impact of mobile phone radiation on…
Article
Formulation and in vitro Evaluation of pH Dependent Colon Targeted Controlled Release Tablet of Mesalamine Containing Cyamopsis tetragonoloba Gum and Sodium Alginate
Muhammad Abid Mustafa, Asad Majeed Khan, Nasir Ali, Fahad Ahmed, Muhammad Usama Latif, Zukhruf Shahid, Minahil Akram, Ambreen Ijaz, Minahil Arif, Ahmad Ilyas, Maria Asghar, Mahgull Mahmood, Tameen Amin
pp. 476–484 · DOI: 10.5530/ijpi.13.3.059 · Published
Objectives: The goal of the study was to treat ulcerative colitis by targeting drug delivery to the colon via the novel ingredient’s guar gum and pH-dependent polymer sodium alginate. The drug was released at a high pH i…
Article
Formulation, Development and Characterization of Liposome-based Gel of Eberconazole Nitrate for Topical Delivery
Nidhi Shah, Khushbu Patel
pp. 485–495 · DOI: 10.5530/ijpi.13.3.060 · Published
Objectives:The present investigation was aimed to develop Liposome-Based Gel (LBG) for Eberconazole nitrate. The purpose was to administer the drug at a sustained rate through skin to improve bioavailability for longer p…
Article
Solubility Enhancement of Nevirapine Using Β-Cyclodextrin Nanosponges
Monica R. P. Rao, Jidnyasa A. Pawar
pp. 496–502 · DOI: 10.5530/ijpi.13.3.061 · Published
Aim:Beta-cyclodextrin-based nanosponges were used to augment solubility and dissolution of Biopharmaceutical Classification System (BCS) class II drug Nevirapine. Materials and Methods: Nanosponges (NS) were prepared usi…
Article
Evaluation of Classical Ayurvedic Medicine for its Neuropharmacological Action
Sujit Dash, Amaresh Chandra Sahoo, Prabhat Kumar Sahoo, Sushanta Kumar Rout, Pratik Jena, Rajlaxmi Barik, Jyotiraditya Mohapatra
pp. 503–511 · DOI: 10.5530/ijpi.13.3.062 · Published
Background: The classical ayurvedic formulation Bru-satavari after consumption by people can get a restful night's sleep and feel rejuvenated. The goal of this study is to look at important phytoconstituents which may in…
Article
Material in Arabica Coffee Powder (Coffea arabica) with Gel-based PCR Method
Soni Muhsinin, Jeane Luthfiyyah, R. Herni Kusriani
pp. 512–515 · DOI: 10.5530/ijpi.13.3.063 · Published
Aim/Background:Arabica coffee (Coffea arabica) is the most consumed coffee in the world. As a result, it is susceptible to imitation Arabica coffee made with corn syrup and other inexpensive components (Zea mays). This s…
Article
GC-MS Analysis and Assessment of the Anthelmintic and Antioxidant Potential of the Aerial Parts of Common Indian Vegetative Plant Lagenaria siceraria (Molina) Standley (LS)
Prasenjit Mondal, Aditya Sarkar, Sourav Dutta, Piyali Khamkat, Vivek Barik, Sumanta Mondal
pp. 516–525 · DOI: 10.5530/ijpi.13.3.064 · Published
Objectives:In this work, the photo components were investigated utilising GC-MS analysis and in vitro antioxidant activity, and the anthelmintic potential of methanolic extract of aerial parts of the Lagenaria siceraria …
Article
Effect of Aqueous Ethanolic Extract of Andrographis paniculata and Adathoda vasica and Role of Trace Elements in Type 2 Diabetic Rat Model
Kavya Manjunath, Purnima Ashok, Rajendran Ramaswamy, Hariprasad Madakasira Guggilla
pp. 526–531 · DOI: 10.5530/ijpi.13.3.065 · Published
Background:Diabetes mellitus is the most prevalent general health worry disorder, causing a significant fatality and long-term medical problems. It is a comprehensive biochemical condition of high blood sugar, insulin re…
Article
Effect of Yohimbine on STZ Induced Diabetic Rats
Peta Sudhakar, Shobha Rani Satla, Anreddy Rama Narsimha Reddy
pp. 532–537 · DOI: 10.5530/ijpi.13.3.066 · Published
Background: Yohimbine has been suggested as a possible therapy for type 2 diabetes mellitus. Thus, we evaluated antidiabetic activity of yohimbine in Streptozocin (STZ)-induced rats. Materials and Methods: Yohimbine's an…
Article
Design, Optimization and Characterization of Newer Herbal Tablet Containing Momordica dioica Extract
Subhashchandra K. Patel, Hirenkumar R. Chaudhary, Tejal R. Gandhi
pp. 538–547 · DOI: 10.5530/ijpi.13.3.067 · Published
Background: Momordica dioica (MD) is called the teasle gourd, spiny gourd, and kakrol. Among the important phytochemicals present in MD include alkaloids, flavonoids, phenolics, tannins, saponins, steroids, glycosides, a…
Article
Design and in silico Prediction of New Methylenedioxyphenyl Derivatives as DNA Topoisomerase II Inhibitors
Swati Rathore, Maadhu Reddemma, Neha Rai, Richa Tripathy Tiwari, Shaheen Begum, Shailendra Patil, Asmita Gajbhiye Patil
pp. 548–558 · DOI: 10.5530/ijpi.13.3.068 · Published
Background:Cancer is the world’s leading cause of death; more than ten million people die from cancer each year. Rate of morbidity and mortality is increasing day by day. As a result, utilizing chemoinformatics technique…
Article
Pharmasure - A Tool to Reduce Mortality and Morbidity Rate
Sumit Shashikant Mude, Mukesh Tatyarao Mohite
pp. 559–565 · DOI: 10.5530/ijpi.13.3.069 · Published
Purpose: In the last decade over 17.46 million people in India died due to wrong medication and drug-drug interaction. In fact, Drug-drug interaction is the 4th leading cause of death in India. Medications used in COVID-…
Article
Synthesis, Characterization and Pharmacological Evaluation of Ultra Short Dipeptides as Antimicrobial and Anticancer Agents
Neha Rai, Swati Rathore, Richa Tripathy Tiwari, Shailendra Patil, Asmita Gajbhiye
pp. 566–573 · DOI: 10.5530/ijpi.13.3.070 · Published
Background:The biological compounds known as peptides are found in nature. They are peptide (amide) links that connect short chains of amino acid monomers. Nowadays, peptide-based therapeutic treatments are employed beca…
Article
Stability Indicating HPTLC Method Development and Validation for Quantification of Favipiravir in Bulk and Commercial Film Coated Tablet
Aishwarya Ramchandra Balap, Aniket Padmakant Dudhe
pp. 574–581 · DOI: 10.5530/ijpi.13.3.071 · Published
Introduction:Favipiravir was remerging antiviral drug in the beginning era of COVID-19 Pandemic as an urgent therapeutic alternative to treat COVID-19. Literature survey reveals that there is no any reported stability in…
Article
Simultaneous Estimation of Lamivudine, Tenofovir Disoproxil Fumarate and Efavirenz in Bulk and Tablet Dosage Form by Cramer’s Rule
Atul Baravkar, Gandhi Santosh, Bawaskar Namrata, Vitthal Chopade, Makarand Puri, Vishnu Neharkar, Ramdas Kale, Dattatray Kature, Rahul Jadhav, Manisha Patil, Reshma Devkate, Alfa Jain, Deepali Kadam, Amol Khedkar, Sachin Vijapure, Nilima Wani, Ganesh Shinde
pp. 582–587 · DOI: 10.5530/ijpi.13.3.072 · Published
Background:Cramer's rule is one of the significant techniques applied to settle an arrangement of conditions. In this rule, the upsides of the factors in the framework are to be determined utilizing the determinants of n…
Article
Validated Reverse-Phase HPLC Method for Quantification of Fluconazole and Quercetin in Pharmaceutical Formulation
Hitesh G. Raval, Ujashkumar A. Shah, Hirak Kumar Joshi, Vaishali T. Thakkar
pp. 588–594 · DOI: 10.5530/ijpi.13.3.073 · Published
Objectives: Fluconazole (FCZ) and Quercetin (QCT) in pharmaceutical dosage form were simultaneously quantified using a sensitive, accurate, robust, and précised Reverse Phase-HPLC Method. Materials and Methods: RP-HPLC m…
Article
Analytical Method Development and Validation of Rivastigmine in its Pure and Pharmaceutical Dosage form Using UPLC
Aarthi Kommu, Raja Sundararajan
pp. 595–604 · DOI: 10.5530/ijpi.13.3.074 · Published
Objectives: For the quantification of rivastigmine in both its pure form and pharmaceutical formulation, an ultra-performance liquid chromatography method with high speed and sensitivity was created and validated. Materi…
Article
High-Cited Papers in Global COVID-19 Vaccine Research
B.M. Gupta, K.K. Mueen Ahmed, Mallikarjun M Kappi, Madhu Bansal, Jivesh Bansal
pp. 605–616 · DOI: 10.5530/ijpi.13.3.075 · Published
Background and Aim:The coronavirus disease 2019 (COVID-19) virus pandemic is still ravaging the world with its ongoing resurgence and continuous mutation, suggesting the need for continuous research on safe and effective…
Article
Analytical Method Development and Validation for Determination of Valganciclovir by Using RP-HPLC
Gaddam Venkata Abhigna, Raja Sundararajan
pp. 617–624 · DOI: 10.5530/ijpi.13.3.076 · Published
Objectives:A novel, precise, and accurate RP-HPLC method was developed and validated for the determination of valganciclovir in pure and medicinal dose form. Cytomegalovirus infections were treated with the antiviral med…
Article
Evaluation of the Antibiotic Prescribing Pattern and Related Adverse Drug Reaction in an India Tertiary Care Hospital: A Prospective Observational Study
Manouchehr Khanipour, Mina Shahraki Mohammadi, Balakeshwa Ramaiah
pp. 625–631 · DOI: 10.5530/ijpi.13.3.077 · Published
Introduction:Antibiotics have important roles in human health, whereas irrational use of antibiotics is a major problem of public health that leads to resistance and ADRs. This study aimed to evaluate the prescribing pat…
Article
Prevalence of Musculoskeletal Disorders and Health Related Quality of Life (HRQoL) in Patients Visiting Secondary Healthcare Setting
Uppara Veerendra, Palagiri Akbar Basha, Byragani Naga Bindu, Deti Pruthvi Bhushan, Gutam Venkata Kalyani
pp. 632–640 · DOI: 10.5530/ijpi.13.3.078 · Published
Introduction:Musculoskeletal disorders are injuries or illnesses that affect the muscles, nerves, tendons, joints, cartilage, and spinal discs. These disorders are characterized by a loss of physical function in the body…
Article
Monitoring Adverse Medication Reactions: Aiding Pharmacovigilance at a Hospital Providing Secondary Care
Kommanuru Venkata Ramakrishna Teja, Yiragamreddy Padmanabha Reddy, Nayakanti Devanna
pp. 641–645 · DOI: 10.5530/ijpi.13.3.079 · Published
Introduction:Although adverse drug reaction (ADR) monitoring is widely known, it is not practised in underdeveloped nations due to a lack of awareness and the absence of a central coordinating agency. The recent implemen…
Article
In vitro Anti-cancer Activity of Nandhi mezhugu (NM) in Ovarian Cancer Cell Line (PA-1) Using MTT Assay
Glara Anest Francis, Sureka Arumugam, Sabari Girija Navaneetha Krishnan, Ramamurthy Murugan, Christian Gnanaraj Johnson, Moses Erin Johnson Christian, Meenakumari Ramasamy
pp. 646–650 · DOI: 10.5530/ijpi.13.3.080 · Published
Introduction: Ovarian cancer is the fifth most common cause of cancer which causes more deaths than any other cancer of the female reproductive system because there is no effective screening and most women are diagnosed …
Article
Investigation of Phytochemical Profile of Ethanolic Extract of Elaeocarpus ganitrus and Desmostachya bipinnata
Harish Gupta, Girendra Kumar Gautam
pp. 651–655 · DOI: 10.5530/ijpi.13.3.081 · Published
The present study is designed to evaluate the phytochemical profile of Elaeocarpus ganitrus and Desmostachya bipinnata. Extraction was performed using ethanol as a solvent for both the plants. Preliminary phytochemical s…
Article
Simultaneous Estimation of Gallic Acid, Vasicine, Pterostilbene and Piperine Using RP-HPLC Method from Ayurvedic Proprietary Formulations
Sanjay U Nipanikar, Pravin S Surwade, Ankita R Kasabe, Priyanka B Patil, Sachin A Upasani
pp. 656–665 · DOI: 10.5530/ijpi.13.3.082 · Published
Introduction: A simple, accurate, precise, sensitive, and validated RP-HPLC method was developed for simultaneous estimation of Gallic Acid (GA), Vasicine (VS), Pterostilbene (PTS) and Piperine (PP) from Ayurvedic Propri…
Article
Preparation and Characterization of Mucoadhesive Proniosomal Gel of Curcumin with Thiolated Chitosan for the Treatment of Oral Mucositis
Shweta Vashist, Manoj M. Gadewar
pp. 666–672 · DOI: 10.5530/ijpi.13.3.083 · Published
Aim:Oral mucositis is a problem which is found in a cancer patient, taking chemotherapy radiation therapy. This work aims to formulate a mucoadhesive curcumin proniosomal gel by using thiolated chitosan for buccal delive…
Article
Drug Utilization Evaluation of Antidiabetic Drugs in a Tertiary Care Teaching Hospital: Analysis from a Randomized Controlled Study
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Bharati Kangrali
pp. 673–679 · DOI: 10.5530/ijpi.13.3.084 · Published
Background: Diabetes Mellitus (DM) is a chronic metabolic condition characterized by high blood glucose levels and changes in carbohydrate, lipid and protein metabolism due to insulin secretion, action, or both.1 Diabete…