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International Journal of Pharmaceutical InvestigationNOW IN
Article

Effect of Yohimbine on STZ Induced Diabetic Rats

Peta Sudhakar1, Shobha Rani Satla2, Anreddy Rama Narsimha Reddy3★★ Corresponding author

  1. 1Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA.
  2. 2Center for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, Telangana, INDIA.
  3. 3Department of Pharmacology, Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Thimmapur, Karimnagar, Telangana, INDIA.

CORRESPONDENCE

Anreddy Rama Narsimha Reddy

Department of Pharmacology, Sree Chaitanya Institute of Pharmaceutical Sciences, LMD Colony, Thimmapur, Karimnagar, Telangana, INDIA.

petasudhakar@gmail.com

Received: 10-03-2023; Revised: 26-04-2023; Accepted: 11-05-2023.

Volume 13, Issue 3 · pp. 532–537 · PUBLISHED · DOI: 10.5530/ijpi.13.3.066

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ABSTRACT

Background: Yohimbine has been suggested as a possible therapy for type 2 diabetes mellitus. Thus, we evaluated antidiabetic activity of yohimbine in Streptozocin (STZ)-induced rats. Materials and Methods: Yohimbine's anti-diabetic effects were investigated by giving male Wistar rats an injection of Streptozotocin (STZ) to cause diabetes and then analyzing their blood samples. Blood Glucose Levels (BGLs) and glucose tolerance was recorded using an FBG and an OGTT, respectively. Triglyceride, Low-Density Lipoprotein (LDL-c), and High-Density Lipoprotein (HDL-c) levels were determined to examine the impact of yohimbine administration on the lipid profile of diabetic rats. Finally, yohimbine's impact on pancreatic histological damage due to diabetes was investigated. Results:Overall, our findings imply that yohimbine, an alpha-2 adrenoceptor antagonist, helped diabetic group have better glucose tolerance. Yohimbine-treated mice had lower BGLs and enhanced lipid profiles, with lessened triglyceride and LDL-c levels and improved HDL-c levels. Histopathological analyses showed that the size and density of pancreatic cells had increased and that they had regenerated remarkably. Conclusion: As a result, we can conclude that yohimbine may have therapeutic value for restoring lipid-carbohydrate equilibrium and in repairing diabetes-related pancreatic damage.

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    Sudhakar, P., Satla, S. R., & Reddy, A. R. N. (). Effect of Yohimbine on STZ Induced Diabetic Rats. International Journal of Pharmaceutical Investigation, 13(3), 532–537. https://doi.org/10.5530/ijpi.13.3.066