GC-MS Analysis and Assessment of the Anthelmintic and Antioxidant Potential of the Aerial Parts of Common Indian Vegetative Plant Lagenaria siceraria (Molina) Standley (LS)
Prasenjit Mondal1★, Aditya Sarkar1, Sourav Dutta1, Piyali Khamkat1, Vivek Barik1, Sumanta Mondal2★ Corresponding author
- 1Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata, INDIA.
- 2Department of Pharmaceutical Chemistry, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, INDIA.
CORRESPONDENCE
Prasenjit Mondal
Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata, INDIA.
Received: 10-01-2023; Revised: 28-02-2023; Accepted: 06-04-2023.
Volume 13, Issue 3 · pp. 516–525 · PUBLISHED · DOI: 10.5530/ijpi.13.3.064
ABSTRACT
Objectives:In this work, the photo components were investigated utilising GC-MS analysis and in vitro antioxidant activity, and the anthelmintic potential of methanolic extract of aerial parts of the Lagenaria siceraria (MEALS). By using the soxhlation method. Materials and Methods:MEALS were made from aerial components, and phytochemical analysis was carried out for a qualitative evaluation. The in vitro antioxidant activity was measured using the ABTS technique, and the current extract was utilised to analyse phytocomponents by GC-MS and study anthelmintic activity on Pheretima posthuma. The extract of Lagenaria siceraria included 59 components, according to the GC-MS study's phytochemical analysis. Results: Results from anthelmintic research reveal that MEALS had paralysis times between 4.76 and 2.17 min and death times between 6.18 and 2.34 min when compared to the medicine Albendazole, which is the gold standard (paralysis time 4.76 min to 2.17 min and death time 5.87 min to 1.96 min on Peritima posthuma in increasing order of concentration). The percentage of scavenging ranged from 33.31% to 82.33% (IC50 143) and by standard medicine (ascorbic acid) from 49.47% to 94.73% (IC50 103) using the ABTS technique in the evaluation of an antioxidant activity. Conclusion: Due to the presence of physiologically active phytocomponents, aerial sections of the Lagenaria siceraria (MEALS) were shown to be potent anthelmintic and antioxidant agents.
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Mondal, P., Sarkar, A., Dutta, S., Khamkat, P., Barik, V., & Mondal, S. (). GC-MS Analysis and Assessment of the Anthelmintic and Antioxidant Potential of the Aerial Parts of Common Indian Vegetative Plant Lagenaria siceraria (Molina) Standley (LS). International Journal of Pharmaceutical Investigation, 13(3), 516–525. https://doi.org/10.5530/ijpi.13.3.064