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International Journal of Pharmaceutical InvestigationNOW IN
International Journal of Pharmaceutical Investigation volume 13, issue 4 cover
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Cover: International Journal of Pharmaceutical Investigation

International Journal of Pharmaceutical Investigation

Volume 13, Issue 4

· pp. 680–922 · 31 articles

Volume
13
Issue
4
Published
Pages
680–922
Articles
31
Sections
3
ISSN
Print - 2230-973X, Online -2230-9713
Journal
IJPI
Review ArticleOriginal ArticleShort Communication

In this issue

Review Article

  1. Review

    A Study of Nitrosamine Impurities and Regulations Governing their Presence in Drug Products

    Lakshmi Prasanthi Nori, Sheik Rehana, Anusha Penamacha, Bhanu Mounika Somalanka, K. Venkateswara Raju

    pp. 680–687 · DOI: 10.5530/ijpi.13.4.085 · Published

    The seriousness of presence of nitrosamines came to Limelight after USFDA and EMEA declared in July 2018 that N-Nitroso dimethylamine and N-N-NDMA are focused on the pharmaceutical medicinal products and particularly use…

  2. Review

    Phyto-Pharmacological Importance with Nutritional Potential of Eleusine coracana Linn.: A Review

    Surya Nath Pandey, Payal Mittal, Gurfateh Singh

    pp. 688–697 · DOI: 10.5530/ijpi.13.4.086 · Published

    The majority of millet is grown in Nigeria, Mali, Faso, Burkina, Chad, China and India. There are many different types of millet found throughout the universe, but finger millet, small millet, foxtail millet, and proso m…

  3. Review

    Type3c Diabetes Mellitus

    Arjun HR, Praveen Halagali, Mohammed Tausif, Vaishnavi J, Rakshith U.R, GS Rakshanaa

    pp. 698–702 · DOI: 10.5530/ijpi.13.4.087 · Published

    Diabetes type 3C is referred to as pancreatogenic diabetes also, which is occurring due to pancreatic cancer, pancreatitis, cystic fibrosis, and also pancreatic disease. In this condition, there is an inconsistent blow f…

  4. Review

    A Study on BioBetters: Various Aspects and Regulatory Approval Process

    Lakshmi Prasanthi Nori, Aditya Nidumolu, Terli Ragdeep, Vyasam Vishnu Vardhan, K. Venkateswara Raju

    pp. 703–710 · DOI: 10.5530/ijpi.13.4.088 · Published

    A new class of biopharmaceuticals are developed by changing profile in terms of chemistry structure and functionality resulting in enhanced efficacy in terms of reduction in immunogenicity toxicity and improvement in hal…

  5. Review

    Protein Phosphatase 2A Activation for the Treatment of Alzheimer Disease-Promises and Challenges

    Prasenjit Mondal, Saptarshi Samajdar, Suman Acharyya, Sumanta Mondal

    pp. 711–720 · DOI: 10.5530/ijpi.13.4.089 · Published

    Alzheimer's disease is a progressive brain condition. It is characterized by alterations in the brain that result in the deposition of certain proteins. The brain shrinks and finally dies as a result of Alzheimer's disea…

  6. Review

    An Overview of a Biomarker in Breast Cancer

    Gandraju Akhila, Nagashree AG, Asha Spandana KM, Hemanth Kumar S, Harshith HS, Vishnu Vardh R, Shailesh T

    pp. 721–734 · DOI: 10.5530/ijpi.13.4.090 · Published

    Cancer is one of the leading causes of death across the world, which is caused by tumours. Breast Cancer (BC) is the most common cancer in women and the second most common cancer death in women. A variety of molecular bi…

  7. Review

    COVID-19 Current Management and Strategies for Future Outlook

    Nayeema Khowser Shaik, Nalluri Poojitha, Kancharla Bhanu Sri Chandana, Maruvajala Vidyavathi, Sai Deepthi Rayadurgam Venkata

    pp. 735–746 · DOI: 10.5530/ijpi.13.4.091 · Published

    The highly infectious Corona Virus Disease 2019 (COVID-19) had spread and created a havoc worldwide due to lack of risk assessment and quick transmission. The outbreak created epicenters are still being reported daily. D…

Original Article

  1. Article

    Formulation and Comparison of Topical Dosage Forms Containing P-Herbo Extract for Acne Therapy

    N. Raghavendra Naveen, Keerthiraj KS, Gaganashree G, Prajitha Biju, Annegowda H V, Sindhoor S M

    pp. 747–753 · DOI: 10.5530/ijpi.13.4.092 · Published

    The objective of the present was to formulate a novel topical P-herbo dosage form by incorporating the extracts of Azadirachta indica, Centella asiatica, and Ocimum gratissum and compare the efficacy. There is a strong c…

  2. Article

    Development and Optimization of Candesartan Cilexetil Loaded Solid Lipid Nanoparticles

    Krithiga Venkatesan, Gouranga Dutta, Damodharan Narayanaswamy, Abimanyu Sugumaran

    pp. 754–762 · DOI: 10.5530/ijpi.13.4.093 · Published

    Introduction: SLNs have a surfactant-stabilized solid lipid core. They circumvent liquid lipid constraints and increase drug stability. Lipids promote oral medication absorption through the lymphatic pathway and replace …

  3. Article

    Formulation and Evaluation of Propranolol Hydrochloride Sustained Release Matrix Tablets Using Different Grades of HPMC and MCC

    Piyali Khamkat, Vivek Barik, Bhakti Bhusan Barik, Aritra Chakraborty, Dipsikha Patra, Prasenjit Mondal, Snigdha Chatterjee

    pp. 763–771 · DOI: 10.5530/ijpi.13.4.094 · Published

    Background: To design and develop propranolol hydrochloride sustained-release tablet formulations using different grades of HPMC and MCC and their in vitro evaluations. The effect on drug release from tablets and other c…

  4. Article

    Development of Albumin Coated Nanoparticulate Capecitabine Suppositories

    Mythili Gopalakrishnan, Subramanian Somaskanthan

    pp. 772–777 · DOI: 10.5530/ijpi.13.4.095 · Published

    Background: Capecitabine (CAP), a BCS class-I drug which is used for the treatment of Colorectal Cancer (CRC). Site specific and enzyme activated drug delivery was achieved by albumin coated nanoparticles. Co-administrat…

  5. Article

    Effective Adsorption of Ciprofloxacin Antibiotic Using of Novel Magnetic Fe3 O4 /Activated Carbon Nanocomposite from Aqueous Solution

    Fatemeh Zisti, Kethineni Chandrika, Davoud Balarak

    pp. 778–783 · DOI: 10.5530/ijpi.13.4.096 · Published

    Background:Pharmaceutical residues are biologically active in trace concentrations. This has increased worries about their potential hazards to human health and living organisms and has highlighted the need to treat them…

  6. Article

    Evaluation of Pharmacokinetic Profile of GLP-1 Receptor Agonist Exenatide in Type 2 Diabetes Experimental Model

    Arshad Nehal Jamali, Rupesh Soni

    pp. 784–788 · DOI: 10.5530/ijpi.13.4.097 · Published

    The study's objective was to evaluate Exenatide for treating Type 2 Diabetic Mellitus (T2DM) in an animal model. The safety profile and dose determination for the in vivo antidiabetic study were established through an ac…

  7. Article

    Denosumab-induced Hypocalcemia in Patients with Osteoporosis and Normal Renal Function

    Zouheir Ibrahim Bitar, Adnan M A Hajjiah, Ossama Sajeh Maadarani, Mahmoud Mostafa Elzoueiry, Mohamed Refaat Gohar, Mohamad Abdelfatah, Fawaz Alabdali

    pp. 789–792 · DOI: 10.5530/ijpi.13.4.098 · Published

    Introduction: The reported hypocalcemia was low in denosumab-treated postmenopausal women with osteoporosis (0.05–1.7% to 7.4%). The major prediction factors were Vitamin D and calcium levels and renal function. Aim:To a…

  8. Article

    Pro-Oxidant and Antioxidant Activity in Female Rat Cerebellum and Hippocampus on Exposure to Aluminium

    Sirisha Kalyani Bandi, Prasunpriya Nayak, Kalyani Mallipeddi, Archana Rajagopalan

    pp. 793–797 · DOI: 10.5530/ijpi.13.4.099 · Published

    Background:The brain is highly susceptible to Aluminium’s (Al) toxic impact due to its elevated lipid content and oxygen utilization but, relatively scanty levels of antioxidants. Al is known for its strong pro-oxidant a…

  9. Article

    Creatinine Clearance as a Screening Tool for Dosage Adjustment among Renal Failure Patients

    Meriga Pramod Kumar, S. Afreen, M. Kalpana, T. Sailaja, M. Venkatesh Naik, M Sureshwara Reddy

    pp. 798–804 · DOI: 10.5530/ijpi.13.4.100 · Published

    Background:As many pharmaceuticals are removed via the kidneys, a dose adjustment for some medications is necessary in individuals with decreased renal function to prevent toxicity. This study aimed to modify the dose in…

  10. Article

    Screening of Native Plants Growing Around an Industrial Area of Mangalore, Karnataka: Perspectives for Phytoremediation

    Chaithra Raviraj, Chakrakodi Shashidhara Shastry, Anish John, Harsha Ashtekar

    pp. 805–811 · DOI: 10.5530/ijpi.13.4.101 · Published

    Aim:To identify native plant species with high tolerance and remediation potential for specific pollutants present in the industrial area, aiming to develop effective and sustainable phytoremediation strategies for envir…

  11. Article

    A Study of Folklore Antifungal Medicinal Herbs among the Tribal Groups of Western Ghats, Coimbatore, Tamil Nadu

    Dhanabalan Rangasamy, Dhiviya Jeyarajan, Lavanya Gunasekaran

    pp. 812–816 · DOI: 10.5530/ijpi.13.4.102 · Published

    Background:The present study has been carried out to explore antifungal property of folklore medicinal herbs Solanum trilobatum, Spathodea campanulata, Syzygium jambos and Tylophora indica prevalent among the tribal comm…

  12. Article

    Bioprospecting of Endophytic Fungi from Phyllanthus acidus Linn. Leaf, Identification of Secondary Metabolite: Quercetin

    Shilpa P. Chaudhari, Priyatama Vijaysing Powar

    pp. 817–827 · DOI: 10.5530/ijpi.13.4.103 · Published

    Phyllanthus acidus (L.), a medicinal plant, shows numerous pharmacological properties like antioxidant, anti-inflammatory, hypoglycemic effects, neuroprotective, anti-diarrheal, anti-pyretic, and analgesic and anaestheti…

  13. Article

    Characterizing the Bioactive Role of Selected Components with Neuroprotective Properties of Two Ethnomedicinal Plants-Acacia catechu and Ficus religiosa

    Rakshita Pawar, Athira Sasidharan, Manohar Kumar, Yogish Somayaji, Ronald Fernandes

    pp. 828–836 · DOI: 10.5530/ijpi.13.4.104 · Published

    Background: Neuroprotection is a process of recovery and salvage of the nervous system, function, and structure of cells. Several modulators are leading to neuronal damage and cell death, causing many neurodegenerative d…

  14. Article

    Synthesis, Characterization and in vitro Anti-bacterial Activity of “2-chloro-N-{[(2-chlorophenyl) amino] sulfinyl}- N-phenylbenzamide Nucleus and its Derivatives”

    Rohit Jaysing Bhor, Shriram Popat Bangar, Dhanashri Bhausaheb Bhagat

    pp. 837–844 · DOI: 10.5530/ijpi.13.4.105 · Published

    Introduction: This study describes a new route to the synthesis of novel (2-chloro-N- {[(2-chlorophenyl) amino] sulfinyl}-N-phenylbenzamide derivatives. Benzamide-based derivatives were prepared through a reaction of ben…

  15. Article

    Tetrandrine, an Effective Inhibitor of COVID-19 Main Protease (Mpro); Insights from Molecular Docking and Dynamics Simulations

    Arifa Begum SK, Shaheen Shaheen Begum, Pranay Bandari, Swapna B, Maadhu Reddemma

    pp. 845–851 · DOI: 10.5530/ijpi.13.4.106 · Published

    Background:Natural products emerged as potential lead molecules in the drug discovery paradigm. During COVID-19 pandemic, researchers explored several natural agents with antiviral activity. The objective of the present …

  16. Article

    Bioinformatics Approach to Evaluate GRIN2B Gene in Depression–An in silico Study

    Usha Adiga, Shreyas Adiga, Tirthal Rai, Desy TM, Neha Martin Honnalli

    pp. 852–857 · DOI: 10.5530/ijpi.13.4.107 · Published

    Introduction: The objective of the in silico study was to evaluate GRIN2B gene using bioinformatics tools so as to discover the probable effect of mutations of this gene as well as its protein-protein interactions with t…

  17. Article

    Molecular Docking Studies and ADME Prediction of Benzimidazole Derivatives on Anti-convulsant Activity by Inhibiting Voltage-Gated Sodium Channel (NavMs)-5HVX

    Rohit Jaysing Bhor, Nirmal Sujata Eknath

    pp. 858–865 · DOI: 10.5530/ijpi.13.4.108 · Published

    Background: Epilepsy was described as utmost common be habitual brain complaint. A typical symptom of epilepsy is unbridled storms due to transient neuronal discharges. Despite the fact that numerous novel anti-convulsan…

  18. Article

    Synthesis and Anti-convulsant Activity of 1-[3-(4-Amin ophenyl)-3-Oxopropanoyl]- 5,5-Diphenyl imidazolidine -2,4-Dione and its Derivatives

    Rohit Jaysing Bhor, Pooja Motilal Rathod, Pooja Nikam

    pp. 866–874 · DOI: 10.5530/ijpi.13.4.109 · Published

    Background: A heterocyclic hydrocarbon with distinct fundamental structural features in its molecular structure of 5, 5-diphenylimidazolidine heterocyclic ring. It is an imidazolidine and aromatic dibenzene fused ring. T…

  19. Article

    Synthesis, Characterization, and in vitro Antimicrobial Screening of Some “1H-Pyrazole’s and 4H-Chromen-4-One’s Derivatives with Penta- Fluoro-Benzoic Acid and 2,3,4,5-Tetra-Fluoro-Benzoic Acid”

    Rohit Jaysing Bhor, Karan Suresh Kadam, Gaikwad Mayur Sitaram

    pp. 875–882 · DOI: 10.5530/ijpi.13.4.110 · Published

    Background: The pyrazole nucleus has a five-membered heterocycle with two nitrogen atoms next to one another. The two nitrogen atoms are near in pyrazole nucleus heterocyclic compounds. Chromones are benzoannelated -pyro…

  20. Article

    Drug Prescribing Pattern in Myocardial Infarction Patients at a Tertiary Care Hospital in South India

    Kirankumar Palli, Vijay Chidrawar, Uppara Veerendra, Suresh Chenchu, Mamatha Devangam, Shruti Shiromwar, Ahmed Aljameeli, Diwakar Mogarala

    pp. 883–888 · DOI: 10.5530/ijpi.13.4.111 · Published

    Background: The use of the evidence-based clinical practice recommendations, offer guide on efficient and prompt therapy of Coronary Artery Disorders (CAD), is inconsistent, especially in developing nations. A wide range…

  21. Article

    A Prospective Study on Risk Factors, and Prescription Patterns in Urolithiasis Patients in Tertiary Care Hospitals of Khammam Region

    Johurul Islam, Abdul Mannan, Ariful Islam, Thirunagiri Praveenkumar, Maram Chinnaeswaraiah

    pp. 889–894 · DOI: 10.5530/ijpi.13.4.112 · Published

    Introduction: Urolithiasis is a hard deposit of minerals and salts that form inside the kidney, ureter, and bladder in the urinary system. Kidney stones are a common disease of the urinary tract. Prevention of stones mai…

  22. Article

    Assessment of Health-Related Quality of Life in Post-Operative Cardiac Surgery Patients in a Tertiary Care Hospital

    Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Ancy Chacko, Purvi Mehta, Gulam Mohiyuddin Naeem Shirol, Christen Tom Nelson

    pp. 895–903 · DOI: 10.5530/ijpi.13.4.113 · Published

    Background: Cardiac surgeries are medical emergencies to prevent life threatening incidents or mortality. However, due to postoperative complications, there is discussion over subjecting high-risk individuals to cardiac …

  23. Article

    Analyzing the Impact of ChatGPT Using Scientometrics

    Mueen Ahmed KK, Chaman Sab M

    pp. 904–914 · DOI: 10.5530/ijpi.13.4.114 · Published

    Aim:A Scientometric study examines the publication’s quantitative and qualitative trends in a particular research area during the year 2023. Materials and Methods: The present study investigates 333 ChatGPT research outp…

Short Communication

  1. Communication

    Evaluation of Momordica cymbalaria Fenzl (MC) In Healing Burn Wounds

    Nagashree Kanchenahalli Shivarajaiah, Salini Parameswaran Nair, Chaithra Surendran Rathi, Vijay Solanki, Raju Koneri

    pp. 915–922 · DOI: 10.5530/ijpi.13.4.115 · Published

    Background:The study aimed to evaluate the potential of Momordica cymbalaria Fenzl (MC) in healing burn wounds. Partial-thickness scald wounds were induced on SD rats by pouring hot molten wax at 800°C on the dorsal area…