Creatinine Clearance as a Screening Tool for Dosage Adjustment among Renal Failure Patients

ABSTRACT

Background:As many pharmaceuticals are removed via the kidneys, a dose adjustment for some medications is necessary in individuals with decreased renal function to prevent toxicity. This study aimed to modify the dose in individuals with renal failure using creatinine clearance as a screening tool. Materials and Methods: From November 2021 to April 2022, prospective observation research was carried out in a government hospital's Department of general medicine. The study includes all patients diagnosed with renal illness above the age of 30, patients with elevated serum creatinine levels, and renal patients with concomitant diseases. From the patients' medical records, information on the serum creatinine level, age, sex, and prescribed medications and their dosages were gathered. The Cockcroft-Gault (CG) equation was used to get the predicted creatinine clearance. The benchmark for dose adjustment was the American College of Physicians Guideline for Drug Prescribing in Renal Failure. Results: In this study, 100 patients were screened, and among them, 60 were found to be CKD patients. 512 drugs were prescribed in 60 patients, of which 505 were appropriately adjusted and 2 drugs were inappropriately adjusted in 7 (11.6%) patients and 53 (83.3) patients were appropriately adjusted. Patients with renal impairment have a median age of 50-60 years (56), a serum creatinine value of 2.4, and an estimated CCR value of 126.8. Comorbidities are present in 45 (or 75%) 60 patients. Conclusion:According to the findings, patients with renal impairment admitted to the hospital frequently made dosing errors. In patients with renal impairment, improving the quality of drug prescriptions may enhance the quality of care overall.

KEYWORDS

• Dose Adjustment
• Renal Failure/Impairment
• Creatinine
• Cockcroft-gault

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• DOI10.5530/ijpi.13.4.100Copy

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