Volume 14, Issue 1

· pp. 1–267 · 32 articles

Volume: 14
Issue: 1
Published
Pages: 1–267
Articles: 32
Sections: 3
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article Case Report

In this issue

Review Article

Review
Navigating Global Regulatory Requirements for Generic Drugs: A Comparative Study of MIST, BRICS, and ICH Countries
Jayant Kumar, Ajmera Ramkishan, Madhugiri Prakash Venkatesh
pp. 1–9 · DOI: 10.5530/ijpi.14.1.1 · Published
Bringing a new healthcare product to market can be challenging, especially when navigating the complex regulatory requirements of different countries. The approval process can be a maze of differing regulations, but this…
Review
Finerenone as a New Potent Resistant Hypertension Agent: A Review
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Jayasheela Hiremath, Abhishek BJ, Saurav Raj, Megha Hegde, Dhananjay Tikadar, Raviteja Somashekhar Kanavi, Rohith Javali Veeresh
pp. 10–15 · DOI: 10.5530/ijpi.14.1.2 · Published
Background:The drug Finerenone, a selective the drug mineralocorticoid receptor antagonist, indicated for Chronic Kidney Disease (CKD) and Type 2 Diabetes. Recent researchers also found add on role in the management of r…
Review
An Overview of Complementary Therapies for Effective Diabetes Management
Himangshu Deka, Ananta Choudhury, Jahnabi Sarmah, Debgopal Ganguly, Rosamund Jyrwa, Dhiraj Baishya, Nurjamal Houque
pp. 16–22 · DOI: 10.5530/ijpi.14.1.3 · Published
Diabetes mellitus is a global health concern resulting in significant morbidity and mortality. Till today there is no known cure available for the condition. The extended treatment schedule, unfavorable side effects of c…
Review
Degradation of Antibiotics by Ultrasound-Assisted Heterogeneous Activation of Persulfate and Peroxymonosulfate: A Review
Sepideh Kianian, Rozhin Moloudpour Toulakani, Fatemeh Zisti, Davoud Balarak, Shaziya Haseeb Siddiqui, Morteza Khodadadi Saloot
pp. 23–29 · DOI: 10.5530/ijpi.14.1.4 · Published
Background:The presence of antibiotic residues in water is a matter of concern for both public health and the environment, owing to the phenomenon of antibiotic resistance. One of the Advanced Oxidation Processes (AOPs) …
Review
Unlocking the Clinical Significance of Cytochrome P450 Enzymes
Rajesh Hadia, Vishal Singh, Nidhi Solanki, Shiwanand Sharma, Varunsingh Saggu, Cyril Sajan, Rahul Trivedi, Sunil Kardani, Sunil Baile, Hemraj Singh Rajput, Rajesh Maheshwari
pp. 30–38 · DOI: 10.5530/ijpi.14.1.5 · Published
Aim/Background:The Cytochrome P450 (CYP) enzyme family, consisting of 57 distinct genes, plays a pivotal role in various biological processes. These genes encode enzymes with multifaceted functions, impacting vital proce…
Review
Recently Isolated Fawcettimine-Type Alkaloids
Shriniwas Pramod Patil, KV Ramanath, Hemant Kumar Jain, Charu Pandya, Bhagyashree Pawar, Seema V Pattewar
pp. 39–47 · DOI: 10.5530/ijpi.14.1.6 · Published
Since long back, many Lycopodiaceae or Huperziaceae plants species like Lycopodium clavatum L. serratum, Huperzia serrata, H. carinata, Phlegmariurus squarrosus and P. henryi are being traditionally used in treatment of …
Review
Role of Traditional Plant Compounds in the Treatment of Neuropsychiatric Diseases
Praveen Halagali, Rohan Singadi, Hunsur Ranganath Arjun, Gundada Sivaraj Rakshanaa, Salini Parameswaran Nair, Prashant Halagali, Preethi Somanna
pp. 48–54 · DOI: 10.5530/ijpi.14.1.7 · Published
Natural elements from nature along with their bioactive components are being extensively studied in recent times for their therapeutic efficacy in treating a variety of degenerative disorders. These diseases are specific…

Original Article

Article
Protection of Fargesin against Hydrogen Peroxide-induced Cell Death in RAW 264.7 Cells
Amira Nabila Mat Roof, Richard Johari James, Salfarina Ramli, Boonchoo Sritularak, Pornchai Rojsitthisak, Hasseri Halim
pp. 55–61 · DOI: 10.5530/ijpi.14.1.8 · Published
Background:The imbalance level of Reactive Oxygen Species (ROS) in the body can lead to oxidative stress in cells, resulting in the progression of chronic diseases. Fargesin, a bioactive lignan found in Flos magnoliae, a…
Article
Implementation of Drug Information Services in a Tertiary Care Hospital: Patients' and Physicians' Perception
Akshay Shankpal, V. P. Yogita, R. Chinmayee, Santhosh Reddy, P. K. Lakshmi
pp. 62–67 · DOI: 10.5530/ijpi.14.1.9 · Published
Background: This study aimed to establish and promote drug information services for healthcare professionals and patients in a tertiary care hospital, and to assess the level of awareness and utilization of the center. M…
Article
A Box Behnken Design Optimized Nano Vesicular Transdermal Patch for Allergies
Charan Sailaja, Pradeep Kumar Bhupalam
pp. 68–75 · DOI: 10.5530/ijpi.14.1.10 · Published
Background:The work aimed to fabricate Loratadine (LRD) niosomes by employing a Box Behnken Design (BBD) and they were subsequently applied to transdermal patches utilizing BBD's solvent casting process.Materials and Met…
Article
Formulation Development and Optimization of Fenoprofen Floating Tablet Using QbD Approach
Gaurav Singh Sikarwar, Mukesh Kumar Gupta
pp. 76–88 · DOI: 10.5530/ijpi.14.1.11 · Published
Aim:The study’s goal was to develop and characterize a new type of Fenoprofen tablet that can float. Materials and Methods: Research on the drug’s performulation was carried out to evaluate its organoleptic qualities, so…
Article
Exploring the Anti-bacterial Potential of Novel 2-Aminophenyl-2-(2,4,5-Triphenylimidazole) Acetate Derivatives: A Comprehensive Design and Synthesis Approach
Piyusha Kolhe, Rahul Godge, Hrishikesh Ghorpade, Gaurav Dhanvate, Anurag Nalawade
pp. 89–100 · DOI: 10.5530/ijpi.14.1.12 · Published
Background: Antibiotic resistance is a growing concern, and the development of new anti-bacterial agents is crucial. 2-aminophenyl-2-(2,4,5-triphenylimidazole) derivatives have shown potential as anti-bacterial agents in…
Article
Spectrophotometric Determination of Favipiravir in Bulk and Pharmaceutical Formulation Using Bromothymol Blue Reagent
Nandini Rebbbaniboni, Seetha Mahithavani, Gayatri Somayala, Malladi Venkata Srihari Lakshman, Jahnavi Bandla
pp. 101–106 · DOI: 10.5530/ijpi.14.1.13 · Published
Background: The primary objective of this research was to establish a spectrophotometric technique to quantitatively analyze the concentration of favipiravir in both its pure form and pharmaceutical preparations using br…
Article
Cardioprotective Potential of Resveratrol Alone and in Combination with Piperine on Isoproterenol-induced Myocardial Infarction in Rat: Investigation on Oral Bioavailability of Resveratrol
Thriveni Raunak Salian, Nadira Noushida, Benachakal Honnegowda Jaswanth Gowda, Manodeep Chakraborty, Sindhu Priya Enumadisetty Srinivasulu, Mohammed Gulzar Ahmed
pp. 107–116 · DOI: 10.5530/ijpi.14.1.14 · Published
Background: Resveratrol (3,4,5-trihydroxystilbene), a polyphenol derived from plant sources, despite its cardioprotective properties, has limited therapeutic impact due to its low in vivo bioavailability and rapid metabo…
Article
Challenges and Future Prospects: A Benefaction of Phytoconstituents on Molecular Targets Pertaining to Alzheimer's Disease
Himanshu Sharma, Phool Chandra
pp. 117–126 · DOI: 10.5530/ijpi.14.1.15 · Published
Background: Many parts of the brain experience excruciating pain as a result of Alzheimer's disease, a form of dementia. Cognitive processes and neuropsychiatric regulation are disrupted by the numerous neuropathologies …
Article
Enhancing Permeability of Acyclovir from Mucoadhesive Buccal films Utilizing Herbal Bioenhancers: An in vitro Investigation
Anjana Chandran, Marina Koland, Sindhoor Shridharan Mulleria
pp. 127–134 · DOI: 10.5530/ijpi.14.1.16 · Published
Background: Acyclovir is a widely used anti-viral drug that has low bioavailability when administered orally and is also difficult to administer parenterally due to its inherent solubility limitations. Buccal administrat…
Article
Assessment of Knowledge, Attitude, Practice and Medication Adherence among Tuberculosis Patients in Tertiary Care Hospital
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Akash Chathamvelli, Kadambari Patil, Anirudh Pai, Aditi Baadkar
pp. 135–140 · DOI: 10.5530/ijpi.14.1.17 · Published
Background:Tuberculosis (TB), a highly contagious and dangerous disease, impacts millions globally, with India topping the list of affected countries. The study aimed to evaluate the knowledge, attitude, practice, and me…
Article
Novel Approaches in Glycogen Storage Disease Type I Management: Harnessing the Potential of Micronutrients and Macro Molecules
Santosh B Patil, Pramod C Gadad
pp. 141–150 · DOI: 10.5530/ijpi.14.1.18 · Published
Background: Genetic metabolic illnesses called Glycogen Storage Disease type I (GSD I) are caused due to abnormalities in the glucose-6-phosphatase enzyme complex involved in the metabolism of glycogen. Objectives: The c…
Article
Simultaneous Estimation of Amlodipine and Enalapril Maleate by Stability Indicating UHPLC Method
Neha Gaikwad, Charushila Bhangale, Sangita Bhandare
pp. 151–159 · DOI: 10.5530/ijpi.14.1.19 · Published
Objectives: The key objective of this work is to establish a stability-indicating UHPLC technique for measuring amlodipine and enalapril maleate in bulk and pharmaceutical formulations Materials and Methods: The mobile p…
Article
Assessment of Medication Adherence in Cardiovascular Patients in Tertiary Care Hospital: A Prospective Observational Study
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Abhishek B J, Amisha Netalakar, Bhoomika S K, Namratha D, Tahameen K Kurabanavar
pp. 160–164 · DOI: 10.5530/ijpi.14.1.20 · Published
Background: Cardiovascular Disease (CVD) is commonly known as disease of heart of blood vessels and is typically composed of fatty deposits. Heart attack and Heart failure are caused by the high levels of fatty tissues b…
Article
Assessment of Postpartum Depression in Women Who Had Cesarean and Normal Vaginal Deliveries
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Lizanne Fernandes, Sadaf Sultana, Saurav Raj, Megha Hegde, Dhananjay Tikadar, Aju Alex, Raviteja Kanavi
pp. 165–171 · DOI: 10.5530/ijpi.14.1.21 · Published
Background: Postpartum Depression (PPD) is one of the least vocalized topics surrounding pregnancy and motherhood in India. The study aimed to assess the postpartum depression in women who had cesarean and normal vaginal…
Article
Docking Sites of Indole Derivative on Mitogen-Activated Protein Kinase (MAPK) Inhibitor (PDB ID- 1A9U) against Inflammation
Rohit Jaysing Bhor, Adesh Chandrakant Agale, Gaikwad Mayur Sitaram, More Dhanraj Navnath, Wayse Siddheshwar Sunil
pp. 172–179 · DOI: 10.5530/ijpi.14.1.22 · Published
Background:The serine/threonine kinase p38 Mitogen-Activated Protein (MAP) kinase is one of the most well studied kinases in the inflammatory process. The goal of this study was to see how a p38 MAP Kinase inhibitor (PDB…
Article
Pharmacokinetic Exploration of Sublingual Route for the Enhanced Bioavailability of Tacrolimus with Rabbit as Animal Model
Jisha Mohanan, Gopinath Subramaniyan, Arul Kuttalingam, Damodharan Narayanasamy
pp. 180–185 · DOI: 10.5530/ijpi.14.1.23 · Published
Introduction: The study aimed to assess the bioavailability of two sublingual formulations i.e., fast-dissolving films and tablets of the poorly bioavailable immunosuppressant drug, tacrolimus, and to compare with its ma…
Article
Effectiveness and Safety of Levonorgestrel Intrauterine Device in Abnormal Uterine Bleeding, Adenomyosis and Perimenopausal Bleeding Patients
Aayushi Jaiswal, Mudumba Srivarshini, Patlolla Akshitha Reddy, Tripura Sundari, Sirisha Sunkavalli, Ramya Vandanasetti, Shaheen Begum, Arifa Begum SK
pp. 186–190 · DOI: 10.5530/ijpi.14.1.24 · Published
Background:The Levonorgestrel-releasing intrauterine system was inserted in patients with conditions like Abnormal Uterine Bleeding (AUB), adenomyosis and Perimenopausal Bleeding (PMB). This study aimed to find the effec…
Article
The Effect of the Mixture of Natural and Cellulose-Based Polymers on the Physicochemical Properties of Sumatriptan Succinate Mucoadhesive Buccal Patches
Sandhya Murali, Prasanth Viswanadhan Vasantha
pp. 191–203 · DOI: 10.5530/ijpi.14.1.25 · Published
Purpose:This study aimed to prepare and evaluate mucoadhesive buccal patches of Sumatriptan Succinate (SUS) made from natural polymers to improve bioavailability, patient compliance, and dose-dependent adverse effects as…
Article
Preparation and Characterization of HydroxyapatiteChitosan Biocomposites of Cissus quadrangularis Linn. for Bone Regeneration in Osteoporosis
Tejas B Patel, Shantilal P Padhiyar, Vipul T Prajapati, Vashisith P Bhavsar, Nishit D. Patel, Dharmik A. Shah
pp. 212–224 · DOI: 10.5530/ijpi.14.1.27 · Published
Background:This research was conducted to create a treatment for osteoporosis (bone degenerating disorder) with hormone replacement therapy using Hydroxyapatites and chitosan as a composite. The research aims to develop …
Article
Socio-economic Status and Depressive Symptoms in Diabetes Patients: A Cross-Sectional Study
Pravalika Mupparapu, Afra Azeenath, Tahsina Firdous, Tamanna Yeasmin, Mohd Azharuddin
pp. 225–231 · DOI: 10.5530/ijpi.14.1.28 · Published
Background: Diabetes is persistent illness that develops mostly when the body produces insufficient amount of the insulin hormone. The insulin hormone regulates blood glucose levels. In recent epidemiological research st…
Article
Assessment of Medication Adherence and Adverse Drug Reactions in Depressive Patients Taking Selective Serotonin Reuptake Inhibitors in Tertiary Care Hospitals in Kerala
Sanju Trizah Saji, Prasanth Viswanadhan Vasantha
pp. 232–238 · DOI: 10.5530/ijpi.14.1.29 · Published
Aim and Objectives: This study examined SSRI-related adverse drug reactions (ADRs), medication adherence, commonly prescribed SSRIs, and gender and age distribution in patients with depression at three tertiary care hosp…
Article
Development and Characterization of Rivastigmine Hydrogen Tartrate Elementary Osmotic Tablets
Ayesha Naz, CVS Subrahmanyam, Shyam Sunder Rachamalla
pp. 239–249 · DOI: 10.5530/ijpi.14.1.30 · Published
Background:The present study aims to develop an Elementary Osmotic tablet (EOP) of Rivastigmine Hydrogen Tartrate (RHT). EOP consists of a core tablet suitably coated with a polymeric solution, and an orifice drilled on …
Article
A Systematic Approach to Vildagliptin-Eudragit RL 100 Coated Nanoparticles by Combined Techniques of Solvent Evaporation and Nano-precipitation Using Quality by Design Concept
Anand Shripal Ammanage, Vinayak Shivamurthi Mastiholimath
pp. 250–257 · DOI: 10.5530/ijpi.14.1.31 · Published
Background:Diabetes is an endocrine disorder characterized by an abnormal increase in blood sugar level. Vildagliptin is a Dipeptidyl Peptidase-4 (DPP-4) inhibitor used in the treatment of type 2 diabetes mellitus. Purpo…
Article
Optimization of Lipase Production from Pseudomonas fluorescens
Lekhana Bandi, Naga Shivani Lakshmisetty, Keerthana Ankireddy, Leela Lakshmi Vaishnavi Pulipati, Asritha Lakshmi Bontu, Ranganadha Reddy Aluru, Chandrasekhar Chanda
pp. 258–262 · DOI: 10.5530/ijpi.14.1.32 · Published
Objectives:Lipases are widely used in biodiesel, food, detergent, and pharmaceutical industries. To fulfil the rising demand for these crucial industrial enzymes, an extensive study on lipases from various micro-organism…

Case Report

Article
Cefadroxil Induced Toxic Epidermal Necrolysis: A Case Report
Megha Hegde, Saurav Raj, Anil Ashvil, Dhananjay Tikadar, Sanatkumar Bharamu Nyamagoud
pp. 263–267 · DOI: 10.5530/ijpi.14.1.33 · Published
Background: Toxic Epidermal Necrolysis (TEN), also known as Lyell's syndrome, is a rare but severe connective tissue condition that is a common cause of substantial skin damage as well as mucous membrane breakdown. This …