Volume 14, Issue 2

The Effect of Halotherapy in Chronic Respiratory Disease: An Adjunct to Physiotherapy-A Narrative Review

Sai Madhav Peddibhotla, Aishwarya Nair, Anju Joby

pp. 268–272 · DOI: 10.5530/ijpi.14.2.34 · Published Oct-Dec 2024

Halotherapy is the use of dehumidified oxygen or salt aerosol microparticles attached to a face to treat pulmonary conditions. It was first reported as a substitute to oxygen masks for speleotherapy, a healing technique …

An Update on Medicinal Importance of the Plant: Polygonum plebeium R. Br.

Sarojini Nayak, Druga Madhab Kar, Saroj Kumar Choudhury, Manoj Kumar Dalai

pp. 273–288 · DOI: 10.5530/ijpi.14.2.35 · Published Oct-Dec 2024

Polygonum plebeium R. Br. (Family: Polygonaceae) is commonly known as “small knotweed”. It is used as a traditional medicine by many cultures across the world. In the rural communities of Shahjahanpur, Uttar Pradesh, it …

Sulbactam and Durlobactam Combination as a Newer Antibiotic for Carbapenem-Resistant Acinetobacter baumannii Infections

Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, B J Abhishek, Leena Elizabeth Varghese, S K Bhoomika

pp. 289–298 · DOI: 10.5530/ijpi.14.2.36 · Published Oct-Dec 2024

This review explores the evolution of the concept of Healthcare-Associated Pneumonia (HCAP) in light of the 2016 guidelines from the Infectious Diseases Society of America (IDSA). These updated guidelines prioritize pati…

Impurities in Drug Substance-An Overview of ICH Q3A, Q3C and M7 Guidelines

Sonal Jesa Dsouza, DS Sandeep, R Narayana Charyulu, MP Gowrav, HK Pradeep

pp. 299–305 · DOI: 10.5530/ijpi.14.2.37 · Published Oct-Dec 2024

Impurities are undesired chemical substances found in pharmaceutical drug products with no therapeutic benefits and, in some cases, can pose a risk to patient safety if their levels exceed a certain limit. Impurities pre…

Harmonised Methods for Detection of Insulin Immunogenicity

Varadarajan Sathiya, V Ramesh Kumar

pp. 306–316 · DOI: 10.5530/ijpi.14.2.38 · Published Oct-Dec 2024

Studying the immunogenicity of insulin is crucial for managing and treating diabetes and other medical conditions. Although insulin therapy is proven effective for diabetic patients, the presence of insulin antibodies ca…

Nano-Revolution in Transdermal Drug Delivery: A Bibliographic Compilation of Vesicular System

Gopinath Subramaniyan, Shaik Rubina, Bachu Venkata Ramana, A. Meriton Stanley, Devasena Srinivasan

pp. 317–326 · DOI: 10.5530/ijpi.14.2.39 · Published Oct-Dec 2024

Background The growing popularity of transdermal patches is attributed to their advantageous characteristics, including the absence of gastric-related problems, prolonged drug release, enhanced safety and stability, and …

A Review on Pharmacological Potential of Various Synthetic and Phytoconstituents in Managing Recurrent Aphthous Stomatitis

Vaibhav Rastogi, Mayur Porwal, Anurag Verma, Umair Khan, Prabal Chauhan, Prashant Kumar

pp. 327–337 · DOI: 10.5530/ijpi.14.2.40 · Published Oct-Dec 2024

Recurrent Aphthous Stomatitis (RAS) is a condition characterized by the development of ulcers and lesions, in the mouth. It affects a wide portion of the population ranging from 5% to 25%. RAS more commonly affects labia…

Personalized Medicine and Advancements in Pharmacology: Shaping the Future of Healthcare

B. Kishore Babu

pp. 338–342 · DOI: 10.5530/ijpi.14.2.41 · Published Oct-Dec 2024

Personalized medicine, driven by advancements in pharmacology, is revolutionizing healthcare by tailoring medical treatments to the unique characteristics of individual patients. This paradigm shift from a generalized ap…

Synergestic Cytotoxicity of Doxorubicin in Combination with Epigallocatechin 3-gallate in Non-Small Cell Lung Cancer by Inhibiting Protein Vimentin

Ashwini Somayaji, Chakrakodi Shashidara Shastry

pp. 343–349 · DOI: 10.5530/ijpi.14.2.42 · Published Oct-Dec 2024

Objectives The purpose of this study was to assess the potential synergistic and chemo sensitizing effects of the plant-derived flavonoid EGCG (Epigallocatechin gallate) as an adjuvant therapy with doxorubicin in combati…

Synthesis and Biological Evaluation of Novel 5,5-Diphenylimidazolidine Derivatives with Anticonvulsant Activity

Rohit Jaysing Bhor, Wayse Siddheshwar Sunil, Rahul Bapusaheb Shirole, Karan Suresh Kadam, Santosh Dighe, Mahesh Hari Kolhe

pp. 350–358 · DOI: 10.5530/ijpi.14.2.43 · Published Oct-Dec 2024

Background A heterocyclic hydrocarbon having a 5, 5-diphenylimidazolidine heterocyclic ring that possesses distinctive fundamental structural characteristics. It is a fused ring of aromatic di-benzene and imidazolidine. …

Evaluation of Hypotensive and Vasodilatory Effects of Murraya koenigii Leaves Extract in L-NAME Induced Hypertensive Rats in Relation with Muscarinic Receptors

Farzana Sadaf, Sumbul Shamim, Humera Ishaq, Ata-ur- Rehman, Ishrat Younus, Faheema Siddiqui

pp. 359–364 · DOI: 10.5530/ijpi.14.2.44 · Published Oct-Dec 2024

Background High Blood Pressure (BP) is a dreadful condition worldwide. Available scientific data confirms the antihypertensive potential of traditional plants. Present study was aimed to assess the blood pressure lowerin…

Thermodynamic Study of Adsorption of Amoxicillin on Synthesized NiO of Pharmaceutical Wastewater

Navid Naghsh, Shiva Barnoos, Fatemeh Zisti, Kethineni Chandrika, Davoud Balarak

pp. 365–370 · DOI: 10.5530/ijpi.14.2.45 · Published Oct-Dec 2024

Background The development of micro-organism resistance in humans and the environment has been linked to the inadequacy of conventional treatment methods in completely eliminating antibiotics. The purpose of this researc…

Multi-Centered Prospective Observational Study on Prescribing Pattern of Anti-Hypertensives in Diabetes Mellitus Type 2 and Chronic Kidney Disease Patients in Eastern Districts of Telangana

Sk. Mehatab Unnisa, Sana Seereen, Jampana Lekhana, Goreti Archana, Annam Hemanth Kumar, Soma Mani Santhosh Nikhil, Maram Chinnaeswraiah

pp. 371–377 · DOI: 10.5530/ijpi.14.2.46 · Published Oct-Dec 2024

Background The most prevalent lifestyle diseases are Diabetes Mellitus type 2 (DM2) and Hypertension (HTN), especially in older age groups, which leads to Chronic Kidney Disease (CKD) as the most possible comorbidity. Ma…

Evaluating the Safety and Effectiveness of Alpha Blockers in the Treatment of Ureteric Stones: A Prospective Observational Study

Rajesh Hadia, Nishee Chhatbar, Priyanka Padiya, Viram Shah, Siddhi Patel, Neel Shah, Hemraj Singh Rajput

pp. 378–385 · DOI: 10.5530/ijpi.14.2.47 · Published Oct-Dec 2024

Background Ureteric stones, characterized by the crystallization of mineral particles in stagnant urine, cause considerable discomfort and pain. Alpha-blockers are employed in the management of ureteric stones to allevia…

Assessment of Drug-Related Problems in Geriatric Patients of Tertiary Care Hospital: A Prospective Observational Study

Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Akshata M Purantar, Bibi Khuteja Jangliwale, Kaushal Kumar, T. P Rakshitha

pp. 386–391 · DOI: 10.5530/ijpi.14.2.48 · Published Oct-Dec 2024

Background Geriatric populations have at high probability of getting drug-related issues due to age-related pharmacokinetic and pharmacodynamic changes. Ageing populations are more prone to have DRPs due to age, drug cha…

Molecular Drug Docking of Multi Drug Resistant Antibiotics (Gentamicin, Linezolid and Norfloxacin) with Staphylococcus aureus C0673 by Implementing Computational Approach

Hezinglila Grace, D. Leelavathi, Kevizano Jacinta Zashumo

pp. 392–398 · DOI: 10.5530/ijpi.14.2.49 · Published Oct-Dec 2024

Background Staphylococcus aureus is an adaptive and versatile microorganism that can cause a wide range of ailments, from intense and short-lived infections to persistent infections that are difficult to cure. Even thoug…

Molecular Docking Studies on Phytoconstituent Isolated from Nyctanthes arbortristis Linn.

Devyani Rajput, Dharmendra Jain, Sushil Kumar Kashaw, Umesh Kumar Patil

pp. 399–408 · DOI: 10.5530/ijpi.14.2.50 · Published Oct-Dec 2024

Background Nyctanthes arbortristis Linn., popularly referred to as Parijat or Night-flowering Jasmine, has garnered significant attention in traditional medicinal practices owing to its wide-ranging array of phytochemica…

Hesperidin Attenuate Olanzapine-Induced Weight Gain, Dysregulation of Lipid and Glucose Metabolism in Rats

Duyu Taaza, Sunil S. Jalalpure, Basanagouda M. Patil, Bhaskar Kurangi

pp. 409–418 · DOI: 10.5530/ijpi.14.2.51 · Published Oct-Dec 2024

Background Olanzapine causes alterations in lipid and glucose metabolism, indicated by weight gain, and altered metabolic profiles. Hesperidin has been related to numerous positive health benefits including improvements …

Assessment of Knowledge and Attitude of Healthcare Professionals and Students towards Clinical Pharmacy Services in Southern India

M Ashwini, K P Kiran, Mamun Ahmed, A P Ravinandan, G Mohammed Mustafa

pp. 419–427 · DOI: 10.5530/ijpi.14.2.52 · Published Oct-Dec 2024

Background Clinical Pharmacy Services (CPSs) is a branch of health sciences which render patient care by optimizing pharmaceutical therapy and providing guidance to patient regarding health, medications and disease preve…

Effect of Bioresorbable Copolymers on Mesalamine Loaded Microspheres for Colon-Specific Drug Delivery

Nimmathota Madhavi, Balaga Divya, Beeravelli Sudhakar, Tadikonda Rama Rao

pp. 428–435 · DOI: 10.5530/ijpi.14.2.53 · Published Oct-Dec 2024

Background Mesalamine produces many side effects through oral route such as stomach cramps, throat irritation, back ache and muscle pain. Furthermore, it failed to yield maximum drug release and also not able to produce …

Benzothiazolo-quinazoline Congeners Function as Anti-microtubule Agents Triggering Mitotic Arrest in Cancer Cells

Supriya Bhukya, Sonam Swain, Darna Mounika, Jyoti Honnanayakanavar, Battu Harish, Purna Chandra Behera, Vidya Jyothi Alli, Surender Singh Jadav, Anthony Addlagatta, Surisetti Suresh, Nishant Jain

pp. 436–453 · DOI: 10.5530/ijpi.14.2.54 · Published Oct-Dec 2024

Background Antimicrotubule agents effectively block cancer spread and are routinely employed as front-line chemotherapeutics. But patients, who receive Paclitaxel, suffer from peripheral neuropathy, which not only lowers…

Identification of DRPs and Assessment of Health-Related Quality of Life in Cardiovascular Patients in Tertiary Care Teaching Hospital

Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Vishwanath Swamy, Amisha Netalakar, S K Bhoomika, D Namratha, Tahameen K Kurabanavar

pp. 454–461 · DOI: 10.5530/ijpi.14.2.55 · Published Oct-Dec 2024

Background Cardiovascular Disease (CVD) commonly known as disease of heart blood vessels and is typically composed of fatty deposits. The WHO estimates that approximately 17.3 million people worldwide die each year from …

A Green Approach to Synthesize Ondansetron Oral Mucoadhesive Tablets by Using Natural Polymers and in vitro Characterization

Muhammad Abid Mustafa, Asad Majeed Khan, Minahil Arif, Nahan Khan, Namra Rasheed, Muhammad Abuzar Ghaffari, Nabeela Jabeen, Areej Faisal, Aneeqa Zia, Abdullah Saleem, Kaynat Azar, Sheeza Khaliq, Hassan Yasin, Ayesha Zulfiqar

pp. 462–471 · DOI: 10.5530/ijpi.14.2.56 · Published Oct-Dec 2024

Background Mucoadhesive buccal tablets are well established, widely used, and commonly accepted oral dosage forms that, by virtue of their adhesiveness, allow the drug to be released gradually over an extended period. Va…

Development and Characterization of Moxifloxacin Hydrochloride Cubogel for Enhanced Ocular Drug Delivery

Bhageerathy Anantha Narayana Iyer, Prasanth Viswanadhan Vasantha

pp. 472–481 · DOI: 10.5530/ijpi.14.2.57 · Published Oct-Dec 2024

Purpose The study aimed to formulate and evaluate an ocular effective prolonged release cubogel formulation of Moxifloxacin Hydrochloride (MX-Cubogel) to treat conjunctivitis. Materials and Methods Initially, a Moxifloxa…

Pharmacognostic Standardization of Stem of Cissus vitiginea L.: A Traditional Siddha Drug

K Sreena, Meenu C Nair, S Ghanthi Kumar, B Neethu Kannan, V L Reena, Sreenidhi M Varma, G S Lekha

pp. 482–492 · DOI: 10.5530/ijpi.14.2.58 · Published Oct-Dec 2024

Background The present study deals with the detailed pharmacognostic investigation of Sidhha single drug, the stem of Cissus vitiginea L. It is a climber that belongs to the family ‘Vitaceae’ with a pantropical distribut…

Formulation and Evaluation of Fumaria parviflora Loaded Oil in Water Emulsion-Based Cream

Anju James, Praveen Halagali, M Jafar, Jose Sanu, Rajath K Bharadwaj, Benwin Shaju, Sahal Basheer, Hunsur Ranganath Arjun, Preethi Somanna

pp. 493–503 · DOI: 10.5530/ijpi.14.2.59 · Published Oct-Dec 2024

Background Fumaria parviflora (FP) is a medicinal herb that is used in several traditional medicines to treat diseases like folliculitis, erysipelas. Fumaria parviflora Lam. belonging to the family Papaveraceae is used w…

Regulatory Pathway for the Approval of Novel Candidate Vaccine

Chandrashekar Ranga, Tanveer Naved, Arti Thakkar

pp. 504–508 · DOI: 10.5530/ijpi.14.2.60 · Published Oct-Dec 2024

Background The need of developing a vaccine on emergency basis to COVID-19 has captured the attention of the regulator during the recent pandemic. There is no comprehensive regulatory pathway for the development of a nov…

Phytofabricated Copper Oxide Nanoparticles from Amaranthus tricolor Leaf Extract: Assessing Antioxidant and Anticancer Potentials

Chrishelle Jaculin, Dhivya Viswanathan, Rajakumar Govindasamy

pp. 509–516 · DOI: 10.5530/ijpi.14.2.61 · Published Oct-Dec 2024

Background This study investigated the biosynthesis of Copper Oxide Nanoparticles (CuONPs) using an environmentally safe and sustainable approach based on Amaranthus tricolor extract. Materials and Methods The synthesize…

Development and Evaluation of Efavirenz Solid Dispersion by Solvent Evaporation and Fusion Methods

Venkata Naga Jyothi Nakka, Kumar Shiva Gubbiyappa

pp. 517–524 · DOI: 10.5530/ijpi.14.2.62 · Published Oct-Dec 2024

Background The bioavailability of the drug is influenced by the solubility of the drug in the biological fluids. Solubility and dissolution are the rate-limiting steps for the absorption and bioavailability of BCS class …

Insights into Antihypertensive Medication Adherence: A Tertiary Care Teaching Hospital Study on Patient Compliance and Influencing Factors

Sudhanshu Shukla, Neeraj Hiremath, Arnab Sarkar, Atharv Mirajkar, Jayasheela Siddhalingayya Hiremath, Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Vishwanatha Swamy

pp. 525–530 · DOI: 10.5530/ijpi.14.2.63 · Published Oct-Dec 2024

Background Hypertension is a chronic long-stay disease that requires proper treatment management and regular medication assessment, which ensure that the disease does not progress into a disorder. Medication Adherence is…

A Breaking Barriers: An Advancing 5-Flucytosine Delivery with Hydrogel Formulation

T Mallamma, Pradeep B. Mirje, Somanagouda Patil, Jayatheertha S. Lokapur, Arpitha J. Lokapur

pp. 531–538 · DOI: 10.5530/ijpi.14.2.64 · Published Oct-Dec 2024

Background Wound healing is a complex physiological process that involves a cascade of events, from inflammation to tissue remodeling. Impaired wound healing can lead to chronic wounds, which are painful and susceptible …

In vitro and In vivo Immunomodulatory Activity of Hydro Ethanolic Extract of Grewia hirsuta Vahl.

Vinuth Chikkamath, Venkatrao Kulkarni, Prasanna Habbu, Anantha Naik Nagappa

pp. 539–546 · DOI: 10.5530/ijpi.14.2.65 · Published Oct-Dec 2024

Background The Advent of the COVID -19 pandemic has necessitated the quick exploration of new drugs. Synthetic approach is time consuming and expensive with uncertainty. The natural products can be explored as this appro…

Fabrication and Characterization of Magnetic Nanoparticles-Embedded Polymer Blend Matrix of Sodium Alginate/Gellan Gum Beads for the Controlled Release of Amikacin Sulfate

Chintha Madhavi, Guntakanti Ujwala, Shaik Shahinshavali, Thammineni Jithendra, Obireddy Sreekanth Reddy

pp. 547–553 · DOI: 10.5530/ijpi.14.2.66 · Published Oct-Dec 2024

Background Magnetic nanoparticles are valued in medical applications for their distinctive properties. In this study, we synthesized magnetic nanoparticles with the aim of employing them for drug delivery. Materials and …

Isolation and Potential Probiotic Characterization of Lactic Acid Bacteria from an Ethnic Fermented Beverage having Antibacterial Activity against Human Pathogen Entamoeba histolytica

Moubonny Das, Pinaki Biswas, Somasri Dam

pp. 554–567 · DOI: 10.5530/ijpi.14.2.67 · Published Oct-Dec 2024

Background Amoebiasis, caused by the human pathogen Entamoeba histolytica is one of the most common parasitic diseases. The existing anti-amoebic drugs show significant side effects in humans. Therefore, for effective co…

Knowledge, Attitude, and Practices about Ayurvedic Immunomodulators among Elderly Diabetic Population during the COVID-19 Pandemic: A Cross-sectional Pilot Study

H S Mythri, Krishnan R Nithin, Raja Ram Mahto, Anil Kumar

pp. 568–576 · DOI: 10.5530/ijpi.14.2.68 · Published Oct-Dec 2024

Background With a high incidence and prevalence of Diabetes and an increase in population of elderly, reports project the number of diagnosed diabetes cases among people 65 years and older will grow more than 4-fold from…

Method Development and Validation for Simultaneous Estimation of Teneligliptin and Pioglitazone by UHPLC Method

Mahesh Hari Kolhe, Sameer Narayan Godase, Kavita Bhushan Vikhe, Rohit Jaysing Bhor

pp. 577–584 · DOI: 10.5530/ijpi.14.2.69 · Published Oct-Dec 2024

Objectives To develop and validate a sensitive, accurate, simple, precise and cost-effective UHPLC method for the simultaneous determination of Teneligliptin and Pioglitazone in pure and its tablet formulation form and v…

Stability Indicating Method Development and Validation of Teneligliptin by UHPLC Method in Bulk and Pharmaceutical Dosage Form

Sameer Narayan Godase, Kavita Bhushan Vikhe, Mahesh Hari Kolhe, Shubham Balasaheb Mhaske, Rohit Jaysing Bhor, Payal Sopan Gawali

pp. 585–592 · DOI: 10.5530/ijpi.14.2.70 · Published Oct-Dec 2024

Background Teneligliptin is a new drug recently approved by FDA for treatment of type 2 Diabetes Mellitus (DMT 2). Very few methods have been reported for analysing its degradation products and their impact on human heal…

Adverse Drug Reactions: Misapprehension and its Consequences

Ravinandan Adavappa Parvathamma, Eswaran Maheswari

pp. 593–594 · DOI: 10.5530/ijpi.14.2.71 · Published Oct-Dec 2024