Volume 14, Issue 3

Jan-Apr 2024 · pp. 595–982 · 36 articles

Volume: 14
Issue: 3
Published: Jan-Apr 2024
Pages: 595–982
Articles: 36
Sections: 3
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article Case Report

In this issue

Review Article

Review
Recent Updates on Unravelling the Therapeutic Potential of Ginger Bioactive Compounds in Cancer Management
Akram Ahmed Aloqbi
pp. 595–606 · DOI: 10.5530/ijpi.14.3.72 · Published Jan-Apr 2024
This review provides an extensive summary of the most current expansions on the therapeutic potential of ginger bioactive compounds in the context of cancer management. We delve into the individual components of ginger a…
Review
Advancing Pediatric Healthcare: Legislation, Clinical Trials, and Technological Innovations in Drug Development
Pratheksha Suresh, Vivek Reddy Murthannagari, Ganesh Gonna Nandhi Krishnan, Neerej Shivashankar, Tholkapiyan Mullaiventhan
pp. 607–615 · DOI: 10.5530/ijpi.14.3.73 · Published Jan-Apr 2024
Historically, there have been constraints on pediatric drug trials, resulting in an absence of authorized medicines for children and a significant reliance on off-label use. Pediatric drug development is critical to addr…
Review
Advancement and Characteristics of Non-Ionic Surfactant Vesicles (Niosome) and their Application for Analgesics
Prachi Pandey, Rahul Pal, Vinay Kumar Rao Khadam, Himmat Singh Chawra, Ravindra Pal Singh
pp. 616–632 · DOI: 10.5530/ijpi.14.3.74 · Published Jan-Apr 2024
Targeted drug delivery systems are employed to administer pharmaceutical medication, facilitating the precise delivery of drugs to specific diseased areas. Several drug delivery systems utilise carriers such as antibodie…
Review
Nanofibers in Drug Delivery Systems: A Comprehensive Scientific Review of Recent Approaches
Koushik Narayan Sarma, Chandrashekar Thalluri, Jithendar Reddy Mandhadi
pp. 633–646 · DOI: 10.5530/ijpi.14.3.75 · Published Jan-Apr 2024
Pharmaceutical formulations, polymer-based nanofibers, which have higher surface area per unit mass of solid, enable and contribute to functions linked to surface shape. Nanofibers can be made using a number of different…
Review
Artificial Intelligence in Oncology: Applications, Challenges and Future Frontiers
Fatmah Alsharif
pp. 647–656 · DOI: 10.5530/ijpi.14.3.76 · Published Jan-Apr 2024
This review article explores the transformative impact of Artificial Intelligence (AI) and Machine Learning (ML) in cancer research. It focuses on the critical role of AI in medical imaging for cancer detection, explorin…
Review
Role of Corticosteroids in Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Gaurav Tiwari, Sagar Narendra Ande, Varsha Deva, Nayyar Parvez, Mahesh Kumar Posa, Saumya Singh, Ruchi Tiwari
pp. 657–669 · DOI: 10.5530/ijpi.14.3.77 · Published Jan-Apr 2024
All patients with Chronic Obstructive Pulmonary Disease (COPD), a multifactorial illness, have decreased post-bronchodilator lung function. While it was once believed that hyperresponsiveness and acute bronchodilator rev…
Review
Agmatine as a Promising Neuroprotective Strategy for Treating Neurological Disorders
K H Harish, Agadi Hiremath Viswanatha Swamy
pp. 670–680 · DOI: 10.5530/ijpi.14.3.78 · Published Jan-Apr 2024
Agmatine, an endogenous amine with cationic properties, serves as a precursor for polyamine synthesis and has diverse pharmacological effects on the central nervous system. Its neuroprotective mechanisms include preventi…
Review
A Review on Herbal Power Bamboo, Papaya, Ginger and Plectranthus in Cancer, Bugs and Oxidant Combat
Umashankar Chikkanna, M Balakeshawa Ramaiah, Shanmuganathan Seetharaman, Vijayan Venugopal, Anandakirouchenane Elumalai, Chandrakala Venkatesh, Gururaj Giligarr
pp. 681–695 · DOI: 10.5530/ijpi.14.3.79 · Published Jan-Apr 2024
This thorough analysis of the article describes the therapeutic potential of herbal treatments, such as ginger, papaya, bamboo shoots, and Plectranthus species, in addressing the complex issues of oxidative stress, micro…
Review
Zebrafish as a Fascinating Animal Model: A Robust Platform for in vivo Screening for Biomedical Research
Manish Kumar Gautam, Pritish Kumar Panda, Anubhav Dubey, Mamta Kumari, Niladry Sekhar Ghosh
pp. 696–701 · DOI: 10.5530/ijpi.14.3.80 · Published Jan-Apr 2024
Background Zebrafish have emerged as an invaluable asset in biomedical research, particularly in comparison to other vertebrate models employed for studying human ailments. Their efficacy in large-scale studies of geneti…

Original Article

Article
Assessment of Antihyperglycemic and Hypolipidemic Activities of Peel Extracts of Annona squamosa, Actinidia deliciosa and Other Two Fruits in Alloxan-induced Diabetic Rats
K Swathi Priya, Veda Priya Gummadi, Gana Manjusha Kondepudi
pp. 702–711 · DOI: 10.5530/ijpi.14.3.81 · Published Jan-Apr 2024
Objectives This study aims to assess the potential antidiabetic properties of aqueous extracts derived from the peels of specific fruits, including A.squamosa, C. melo, A. deliciosa and M. pumila. Materials and Methods M…
Article
Developing New Organometal Complexes of Schiff Base Derivatives with Anticancer Potentials
Basavaraj Dinnimath, Mahesh Palled, Shradha Sutar, Shradha Tashildar, Utkarsh Chavan, Sampada Ganpule
pp. 712–737 · DOI: 10.5530/ijpi.14.3.82 · Published Jan-Apr 2024
Organometallic compounds are gaining prominence today as they are found to be potent anticancer agents due to their diverse chemical nature along with the metal with which they are chelated. In these organometallic compo…
Article
Characterization of Oxiconazole Nanoemulsion Using Box-Behnken Design and Transformation of the Selected Nanoemulsion into Nanoemulgel
Lakshmi Usha Ayalasomayajula, Chandra Sekhar Patro, Saroj Kumar Raul
pp. 738–748 · DOI: 10.5530/ijpi.14.3.83 · Published Jan-Apr 2024
Background The present work covers the preparation and investigation of Nanoemulsion (NE) based hydrogel i.e., Nanoemulgel (NEG) of an Antifungal drug Oxiconazole delivered topically. Materials and Methods High-speed hom…
Article
Formulation and Evaluation of Quercetin Ethosomal Hydrogel for Topical Delivery System
Prashant Halagali, Vishal I Wannur, Abishek Kumar A Patil, Vaibhavi D. Torgal, Shrikrishna M Naik, Santosh A Marennavar, Sakshi Shahapurmath, Pankaj Patil
pp. 749–758 · DOI: 10.5530/ijpi.14.3.84 · Published Jan-Apr 2024
Introduction Ethosomes are non-invasive drug delivery systems that enable drugs to enter the bloodstream or deep layers of the skin and these are phospholipid-based elastic Nano vesicles with a high ethanol concentration…
Article
Hepatoprotective Properties of Polyherbal Extract: A Promising Approach for Liver Necrosis Management
Suvarna Sanjay Khairnar, Mohammed Saad, Jubershaha Salimshaha Fakir, Yogesh Suresh Ahire, Ziyaurrahman Ataurrahman, Nayana Kailas Patil
pp. 759–767 · DOI: 10.5530/ijpi.14.3.85 · Published Jan-Apr 2024
Aim/Background Alcohol-induced liver necrosis requires effective treatment. This study tests Polyherbal Extract’s hepatoprotective effects on alcohol-induced liver necrosis in rats. The extract’s impact on inflammatory p…
Article
Mutational Study of Voltage-Gated Sodium Channel in Permethrin Resistance in Mosquitoes: An in silico Study
Parag Patgiri, Biru Goyary, Mritunjoy Kumar Roy, Ananta Swargiary, Nisha Rani Brahma, Bihung Brahma
pp. 768–774 · DOI: 10.5530/ijpi.14.3.86 · Published Jan-Apr 2024
Background Resistance to insecticides is one of the major problems in successfully controlling of mosquito-borne diseases. The present study explores the role of Voltage-Gated Sodium Channel (VGSC) and their mutation in …
Article
Impact of Consistent and Standardized Administration of Peyadi Samsarjana Krama in Post-Vamana-Virechana (Dietary Regimens Post Emesis and Purgation Therapies) Protocols: A Quasi-Randomized Control Trial
Sandeep S Sagare, Ashok Patil, B S Prasad, S Kadambari
pp. 775–785 · DOI: 10.5530/ijpi.14.3.87 · Published Jan-Apr 2024
Background Ayurveda, an ancient holistic health system, underscores personalized well-being through tailored approaches to health and disease. The post Vamana-Virechana procedures are vital in Ayurvedic detox, promoting …
Article
Mesalamine-Loaded Microsponges as a Potential Strategy for Colon-Specific Anti-Inflammatory Therapy: Design and Evaluation
Naveena Katta, Ashwini Madhava, Preethi Sudheer
pp. 786–793 · DOI: 10.5530/ijpi.14.3.88 · Published Jan-Apr 2024
Background This study aimed to develop an efficient drug delivery system targeting the colon to treat inflammatory conditions using mesalamine. The approach involved formulating microsponges with Eudragit polymers, focus…
Article
Preparation and in vitro Characterization of Diacerein Microsponges Loaded Topical Gels
Shaffi Khurana Tangri, G gnanarajan, Vaibhav Sisodiya, Himanshu Rana, Mehak Garg, Pranshu Tangri, Vaishali Pathania
pp. 794–805 · DOI: 10.5530/ijpi.14.3.89 · Published Jan-Apr 2024
Background This study’s objective was to create and assess diacerein-loaded microsponges incorporated into a topical gel formulation for enhanced skin delivery. Diacerein is a potent anti-inflammatory agent used in the m…
Article
Design and Optimization of Brimonidine-Embedded Hydrogel: In vitro and in vivo Characterization
Dipti Gohil, Dixit Patel, Nirmal Shah, Chintan Aundhia, Sunil Kardani, Rahul Trivedi
pp. 806–813 · DOI: 10.5530/ijpi.14.3.90 · Published Jan-Apr 2024
Background Topical alpha agonists approved by the FDA are used to treat rosacea. Because of its potent vasoconstrictor properties, brimonidine tartrate topical gel (0.33%) efficiently reduces erythema. The aim of this in…
Article
Bio Formation of Silver-Nanoparticles Besides Antimicrobial Activity from Andrographis beddomei C.B. Clarke Leaves
Sunanda Thakur, Putta Venkata Nagendra Kumar, Kamal Shah, Medari Ravinder, Subhash Bhima Pawar, Byalla Sadasivaiah, P Shivakumar Singh, Nagendra Singh Chauhan
pp. 814–821 · DOI: 10.5530/ijpi.14.3.91 · Published Jan-Apr 2024
Background Bio formation of the silver nanoparticles are eco-friendly, low cost, within short period could synthesised and widespread significances also performances. Objectives Seldom, the creation of extra-cellular sil…
Article
Development of a Robust and Reliable RP-HPLC Method for the Estimation of Vericiguat in Tablet Dosage Form: Greenness Analysis using AGREE Penalties
Arram Madhavi, Medidi Srinivas, Niraj Gupta
pp. 822–832 · DOI: 10.5530/ijpi.14.3.92 · Published Jan-Apr 2024
Objectives A simple and sensitive analytical method was developed to quantify the vericiguat in tablet formulation. Materials and Methods The analyte was separated on a Kromacil C column (250 mm×4.6 mm×5 μm particle size…
Article
Development and Validation of UV-visible Spectrophotometry Method for Simultaneous Estimation of Rutin and Curcumin in Bulk Pharmaceuticals
Daneshwari Bhusannavar, Bhuvneshwari Sharannavar, Nithyananda Sastry Darbha, Shailendra Suryawanshi, Sarvesh Patil, Parixit Bhandurge
pp. 833–842 · DOI: 10.5530/ijpi.14.3.93 · Published Jan-Apr 2024
Background The primary objective of this study is to pioneer a novel UV spectrophotometric method, designed with simplicity and high sensitivity to accurately measure both Rutin and Curcumin simultaneously. Rutin has a t…
Article
Chou-Talalay Analysis: Exploring Synergistic Pharmacological Effects of 5-Fluorouracil and Curcumin for Dose Optimization
Sankaranarayanan Vijayalakshmi, Somaskandan Subramanian, Sellappan Malathi
pp. 843–850 · DOI: 10.5530/ijpi.14.3.94 · Published Jan-Apr 2024
Background 5-Fluorouracil (5-FU) is a chemotherapy drug commonly used in the treatment of colon cancer. There is a significant drive to mitigate the limitations of 5-fluorouracil while maintaining its therapeutic potency…
Article
In silico and in vitro Antityrosinase Activity of the Non-Protein Fraction from the Sericin Extract of Antheraea proylei J.
Shamjetshabam Babeeta Chanu, Laishram Rupachandra Singh, Sanjenbam Kunjeshwori Devi, Sanasam Yaiphabi, Birson Ingti, Taranga Jyoti Baruah
pp. 851–856 · DOI: 10.5530/ijpi.14.3.95 · Published Jan-Apr 2024
Background Tyrosinase is an enzyme involved in the production of L-DOPA. To look for novel tyrosinase inhibitors, we investigated the non-protein fraction from the sericin extract of the silk cocoon shell of Antheraea pr…
Article
In silico Molecular Docking and Molecular Dynamics Simulation Analysis of Matairesinol with Molecular Targets in Non-Small Cell Lung Carcinoma
Balaji Rathnam Kamalarathnam, Vadivelan Panneerselvam Karthik, Parvathreddy Sowmya, Kavitha Ramasamy
pp. 857–872 · DOI: 10.5530/ijpi.14.3.96 · Published Jan-Apr 2024
Background Lung cancer is the most reported cancer worldwide and therapeutic resistance poses a major challenge. This in silico molecular docking and molecular dynamic simulation study was carried out to evaluate the bin…
Article
Design and Characterization of Fast Dissolving Solid Dispersion Tablets of Gliclazide
Narayanamma Lakshmi Mudunuru, Kalyan Chakravarthy Janjanam, Rajeswari Saripilli
pp. 873–880 · DOI: 10.5530/ijpi.14.3.97 · Published Jan-Apr 2024
Background Diabetic mellitus is the oldest and most commonly occurring disease known as a life-threatening disease in all age groups from the past 3000 years ago, which is taking away the liveliness from the persons and …
Article
ICH Q1 a Stability Testing for New Dosage Form
Adhithyanarayana Bhat Kodangodlu Subhramanya, Prashant Nayak, Harshitha Ramalingappa, Harish Kachcharavi Hemanna, Prerana Shetty
pp. 881–887 · DOI: 10.5530/ijpi.14.3.98 · Published Jan-Apr 2024
Background This study presents a comprehensive study on applying the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use Q1A R2 guideline for conducting stability tests on …
Article
3D Printed Medical Devices: Regulatory Standards and Technological Advancements in the USA, Canada and Singapore-A Cross-National Study
Megha Ganesh Bhise, Lima Patel, Khyati Patel
pp. 888–902 · DOI: 10.5530/ijpi.14.3.99 · Published Jan-Apr 2024
Background 3D printing, also known as additive manufacturing, is a rapidly advancing technology in the life sciences sector. Several countries, including the USA, Canada and Singapore, have established regulations for 3D…
Article
Evaluation of Anti-Alzheimer’s Activity of Spirulina Platensis and Clerodendreme inerme Plant Extracts
Mrunalini Devi Kotagiri, Shiva Kumar Gubbiya
pp. 903–914 · DOI: 10.5530/ijpi.14.3.100 · Published Jan-Apr 2024
Background Alzheimer’s Disease (AD) is the most prevalent cause of dementia globally and its frequency increases as the world’s population ages. AD is one of the largest healthcare issues of the 21st century as the prima…
Article
Exploration of AQbD Approach for Development of RP-HPLC Method of Nebivolol
Krantisinha Hanumant Randive, Meenaxi Maruti Maste, Amolkumar Ashok Kempwade
pp. 915–927 · DOI: 10.5530/ijpi.14.3.101 · Published Jan-Apr 2024
Background Nebivolol hydrochloride (NBV) is a highly selective beta-adrenoceptor antagonist belonging to the third generation of beta-blockers. It is primarily utilized in the management of cardiovascular conditions. Sin…
Article
Fungal Infections: Effect of Eudragit RL-100 Based Miconazole Film Forming Spray
Kavin Panneerselvam, Subramanian Somaskanthan
pp. 928–934 · DOI: 10.5530/ijpi.14.3.102 · Published Jan-Apr 2024
Background Miconazole nitrate, a BCS class II drug which is used for treatment of fungal infections. To minimize the disadvantages of sticky creams and ointments and their tendency to rub off, an intelligent dosage regim…
Article
Development and Optimization of Febuxostat Emulgel for the Treatment of Gout
Mahek Shah, Lajja Patel, Shailvi Shah, Khushali Parekh, Mohit Shah, Dhaivat Parikh, Tejal Mehta
pp. 935–945 · DOI: 10.5530/ijpi.14.3.103 · Published Jan-Apr 2024
Background Gout is a chronic disease caused by the accumulation of uric acid crystals in joints, resulting in sudden pain, stiffness, and swelling. Febuxostat (FBX), a xanthine oxidase inhibitor, is commonly used to trea…
Article
Advancement and in vitro Characterization of an Ocular Gel Containing Chitosomal Encapsulated Drug for Glaucoma Therapy
Mohini Rawat, G. Gnanarajan
pp. 946–958 · DOI: 10.5530/ijpi.14.3.104 · Published Jan-Apr 2024
Background The most popular and well-designed nano-carriers for drug delivery targeting are liposomes. In order to overcome barriers to cellular and tissue uptake and increase medication bio-distribution to target areas …
Article
Stability Indicating Method Development and Validation of Vildagliptin and Dapagliflozin in Bulk and in Marketed Formulation by UHPLC Method
Vaishnavi Vilas Galande, Mahesh Hari Kolhe, Aditi Rajendra Khatal, Rohit Jaysing Bhor, Payal Sopan Gawali, Pratibha Sudhakar Bhalerao, Manjusha Pandharinath Mhaske
pp. 959–965 · DOI: 10.5530/ijpi.14.3.105 · Published Jan-Apr 2024
Aim Vildagliptin and Dapagliflozin in fixed-dose combination is used for treatment of Type II Diabetes Mellitus. The key objective of the current research work is to develop a new stability-indicating UHPLC method for th…
Article
Identification, Separation and Characterization of Acidic and Oxide Degradation of Atazanavir Sulphate Under ICH-Recommended Stress Conditions by HPTLC with MS/ TOF
Pallavi Patil, Sandhya Bagde, Kalyani Kalad, Varsha Pawar, Neha Shegokar, Sakshi Bharti
pp. 966–979 · DOI: 10.5530/ijpi.14.3.106 · Published Jan-Apr 2024
Background Studies have indicated that atazanavir is prone to degradation in environments with high levels of acidity and oxidative stress. However, the drug demonstrated stability when exposed to basic, neutral, photoly…

Case Report

Article
Chlorpromazine-Induced Parkinsonism: A Case Report
Megha Hegde, Saurav Raj, Dhananjay Tikadar, Sanatkumar Bharamu Nyamagoud, Suhana Nawab, Muskan Padgutti, Musharraf Chandsha
pp. 980–982 · DOI: 10.5530/ijpi.14.3.107 · Published Jan-Apr 2024
Background The side effect of Parkinsonism due to chlorpromazine emerged three years after its approval for public use, leading to the understanding that conventional anti-psychotics could induce various Extrapyramidal S…