Volume 14, Issue 4

Jan-Apr 2024 · pp. 983–1298 · 36 articles

Volume: 14
Issue: 4
Published: Jan-Apr 2024
Pages: 983–1298
Articles: 36
Sections: 3
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article Case Report

In this issue

Review Article

Review
Tumor Invasion and Metastasis: A Current and Emerging Therapeutic Approaches
Abdulaziz Mohammed Asiri, Amer Ali Ahmad Al, Maryam Musleh Althobiti, Mohammed Haidar Abu-Alghayth
pp. 983–997 · DOI: 10.5530/ijpi.14.4.108 · Published Oct-Dec 2024
Background Cancer stands as a significant global health concern, leading to considerable patient suffering and death. The prognosis of patients is intricately connected to the metastatic extent of the disease to aloof si…
Review
An In-depth Review of Exploring the Potential of Colloidosomes in Drug Delivery
Gaurav Tiwari, Santosh Karajgi, Vattakkalvalasu Ramathan Ravikkumar, Ram Kumar Choudhary, Jegannathan Kannan Shyamala, Vinod Kumar, Sreenivas Pippalla
pp. 998–1009 · DOI: 10.5530/ijpi.14.4.109 · Published Oct-Dec 2024
Colloidosomes, pioneering microcapsules composed of coagulated colloidal particles assembled at the interface of emulsion droplets, have garnered significant attention due to their remarkable properties and potential app…
Review
Precision Medicine: Unveiling Progress Amidst Challenges
Piyush Yadav, M Sreelakshmi, Vikas Chauhan, Ritu Mishra
pp. 1010–1018 · DOI: 10.5530/ijpi.14.4.110 · Published Oct-Dec 2024
Precision medicine is an approach to provide individualized treatment to the patient for a specific disease based on the genotypic, phenotypic and also psychological factors which in turn enhances the patient care to sev…
Review
Quality System Requirements of Dietary Supplements: An Overview of 21 CFR Part 111
M Keerthana, DS Sandeep, T Shailesh, KM Asha Spandana, S Kathirvel, HK Pradeep
pp. 1019–1024 · DOI: 10.5530/ijpi.14.4.111 · Published Oct-Dec 2024
FDA has implemented 21 CFR 111 guidelines to regulate the production of dietary supplements that are sold in dosage forms. Creating an effective quality system demands both time and financial resources. However, the robu…
Review
Exploring the Therapeutic Potential of Selenium Nanoparticles in Central Nervous System Disorders: A Nanomedicine Approach
Prajwal Chamanahalli Balaraju, Jayanth Baburayanakoppal Manchegowda, Chandan Kumar, Bharathi Doddla Raghunathanaidu, Ananth Gowda K M Doddi Hanumaiah, Varun Nagamangala Lokesha, Syed Sagheer Ahmed
pp. 1025–1034 · DOI: 10.5530/ijpi.14.4.112 · Published Oct-Dec 2024
In the realm of healthcare, Central Nervous System disorders pose a formidable challenge, affecting countless lives globally. Conditions like Alzheimer’s, Parkinson’s and traumatic brain injuries exact a heavy toll. Howe…
Review
A Critical Review on Computational Techniques through in silico Assisted Drug Design
Pawan Kumar Gupta, Yogendra Pal, Prashant Kumar, Shweta Gupta, Shiv Dev Singh, Shashi Bhooshan Tiwari
pp. 1035–1041 · DOI: 10.5530/ijpi.14.4.113 · Published Oct-Dec 2024
Advancements in computational techniques have revolutionized the field of drug design, offering a powerful arsenal of tools collectively known as in silico methods. This review provides an overview of the diverse computa…
Review
Antimicrobial Efficacy of Metal-Doped Titanium Dioxide Nanoparticles: A Comprehensive Review
Mujibullah Sheikh, Saniya Makkad, Sanskruti Shende, Mrunal Deshmukh
pp. 1042–1051 · DOI: 10.5530/ijpi.14.4.114 · Published Oct-Dec 2024
Titanium dioxide nanoparticles, or TiO2 NPs, have shown potential in the fight against a range of diseases, including bacteria, viruses, fungi and parasites. Doping metals with nanoparticles modify their size and magneti…
Review
Indole Moiety in Organic Synthesis: A Comprehensive Review of Methods and Mechanisms
Akanksha Porwal, A Rajendiran, Parwz Alam, Himanshu Singh, Kratika Singh, Ayush Dubey
pp. 1052–1060 · DOI: 10.5530/ijpi.14.4.115 · Published Oct-Dec 2024
The indole moiety, a prevalent and versatile heterocyclic scaffold, plays a pivotal role in the realm of organic synthesis, underpinning the structural basis of myriad natural products, pharmaceuticals and advanced mater…
Review
Antibacterial Activity of Psoralea cordifolia Linn.: A Systematic Review
Harlin Swer, Bharat Rathi, Anita Wanjari, Payal Raut, Aditi Shinde, Manasi Chunchuwar, Anjali Katore
pp. 1061–1068 · DOI: 10.5530/ijpi.14.4.116 · Published Oct-Dec 2024
Background Psoralea cordifolia Linn. is also known as Bakuchi in Sanskrit and is found all over India. It has long been known for its therapeutic benefits and use in a variety of ailments. This plant belongs to the Fabac…
Review
Unlocking Drug Potential by Enhancing Poor Drug Solubility and Bioavailability through Hot-Melt Extrusion
Maged Mohammed Abdo Mohsen, Amit B Patil, Manohar Sidramayya Kalhandaki, Deepak Kumar Jha, Sangram Ambalgikar
pp. 1069–1078 · DOI: 10.5530/ijpi.14.4.117 · Published Oct-Dec 2024
Today’s drugs, not all usually soluble and easy to formulate drug actives, they might be potent drug molecules at their specific target, they can never become a successful therapy, or molecule, or product if they are not…
Review
Assessment of Medication Adherence and Common Non-Adherence: A Routinely Overlooked Hurdle
Sindoora Dabbe Seetharama, Akalu Srinivas Kamakshi Shriya, Vaishnavi Bharat Pawar, Balaji Sathyanarayana Gupta, Shilpa Palaksha
pp. 1079–1084 · DOI: 10.5530/ijpi.14.4.118 · Published Oct-Dec 2024
Medication adherence has always been an integral aspect to achieve any healthcare benefit of pharmacological treatment. Although health care has evolved remarkably, the need for conducting studies on medication adherence…
Review
Recent Advancement in Exosome-Inspired Lipid Nanovesicles for Cell-Specific Drug Delivery
Siva Prasad Sunkara, Nihar Ranjan Kar, Shaik Kareemulla, Koushik Narayan Sarma, Komal Umare Thool, Manoj Kumar Katual, Pydiraju Kondrapu
pp. 1085–1095 · DOI: 10.5530/ijpi.14.4.119 · Published Oct-Dec 2024
Exosomes are small nanovesicles that are produced through the fusion of multiple veins and plasma membranes, then escaping into adjacent body fluids. Considerable attention has been paid to them due to their potential as…
Review
Research Developments and Understandings in the Dynamics of COVID-19: A Comprehensive Review
Abdulrahman Alzahrani
pp. 1096–1114 · DOI: 10.5530/ijpi.14.4.120 · Published Oct-Dec 2024
The ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has spurred unprecedented research efforts worldwide. This comprehensive scientific review synthesizes key research developments and understandin…
Review
Exploring the Pharmacological Potential of Isoquinoline Derivatives: A Comprehensive Review
Chitrashree Mahadeviah, Purushotham Karadigere Nagaraj, Thoppalada Yunus Pasha, Priyanka Marathi
pp. 1115–1121 · DOI: 10.5530/ijpi.14.4.121 · Published Oct-Dec 2024
The core structure is an aromatic heterocyclic organic compound i.e. Isoquinoline. Both the structures of Isoquinoline and quinoline contain a fused ring structure of benzene and pyridine. Isoquinoline, the pyridine coun…
Review
Exploring the Potential of Hesperidin and Synergistic Formulations in Breast Cancer Management: A Comprehensive Review
Cynthia Lizzie Lobo, Pavithra Pradeep Prabhu, Akhilesh Dubey, Amitha Shetty, Manohar Mahadev
pp. 1122–1130 · DOI: 10.5530/ijpi.14.4.122 · Published Oct-Dec 2024
Hesperidin, a natural compound abundant in citrus fruits, shows promise in breast cancer management due to its safety and diverse mechanisms of action. This review explores hesperidin’s origin, chemical properties, and i…

Original Article

Article
Stability Indicating Bioanalytical Method Development and Validation for Estimation of Remogliflozin Etabonate by RP-HPLC in Human Plasma
Poonam Dada Waditake, Mahesh Hari Kolhe, Mayuri Kailas Mate, Rohit Jaysing Bhor, Pratibha Sudhakar Bhalerao, Manjusha Pandharinath Mhaske
pp. 1131–1137 · DOI: 10.5530/ijpi.14.4.123 · Published Oct-Dec 2024
Background Remogliflozin etabonate belongs to the gliflozin class used for the treatment of type 2 diabetes mellitus and non-alcoholic steatohepatitis. Objectives The objective of the present study is to develop an accur…
Article
Asiaticoside Alleviates Neuroinflammatory Complications of Intracerebral Hemorrhage in Adult Zebrafish
Madhan Kumar Srinivasan, Lalitha Vaidyanathan, Juwala Malinika, Sangeetha Chellapandi
pp. 1138–1146 · DOI: 10.5530/ijpi.14.4.124 · Published Oct-Dec 2024
Background One of the etiologies of stroke is intracerebral hemorrhage and the demand for potential therapeutic agents to alleviate symptoms and improve quality of life in patients with ICH is growing. Several phytocompo…
Article
Green Assessment of Analytical Procedure for the Determination of Anti-Retro Viral Drugs by HPLC
Bommaiah Prakash Kumar, T Yunus Pasha
pp. 1147–1154 · DOI: 10.5530/ijpi.14.4.125 · Published Oct-Dec 2024
Aim The proposed study was to establish a Greener method and validation, by green chromatography technique for combined anti-viral drugs, measuring greenness using various tools, which is one of the emerging developments…
Article
Preparation and Evaluation of Multitargeted Berberine Microemulsion
Sharada Laxman Deore, Bhushan Arun Baviskar, Shretali Sawarkar, Shraddha Bhalake, Anjali Kide, Bhavana Shende, Ram Vighne
pp. 1155–1165 · DOI: 10.5530/ijpi.14.4.126 · Published Oct-Dec 2024
Background Berberine, a phytochemical, possesses remarkable potential for multitargeted drug therapy in microbial infections, wound healing and anti-inflammatory applications. However, its clinical utility in skin and ot…
Article
A Study on Patterns and Predictors of Ascites Outcomes in a Tertiary Healthcare Setting
Vankodoth Sireesha, Yapachetty Pravarsha, Sumaya, Kompalli Varun, N. Chaitanya, CH Meghana, K. Megana
pp. 1166–1173 · DOI: 10.5530/ijpi.14.4.127 · Published Oct-Dec 2024
Background Ascites is the accumulation of abdominal fluid in the peritoneal cavity. Liver cirrhosis, Alcoholic liver disease, Intra-abdominal malignancy, and tuberculosis are the significant etiologies of ascites. In our…
Article
Trend Analysis of Anti-Viral Drugs Approved by USFDA during 2019-2023
Gopi Chand Raguri, Koushik Yetukuri, Rama Rao Nadendla
pp. 1174–1180 · DOI: 10.5530/ijpi.14.4.128 · Published Oct-Dec 2024
Introduction The discovery of new drugs is crucial for pharmaceutical research, development and patient care. One way to achieve this goal is by repurposing existing pharmaceuticals, which can provide valuable insights i…
Article
Bioactive Eucalyptus and Peppermint Oil Blend Microemulsion Preparation, Characterization and Evaluation
Tripti Pendharkar, Abhijeet Soni, Jagdeep Singh Dua, Utpal Jana
pp. 1181–1191 · DOI: 10.5530/ijpi.14.4.129 · Published Oct-Dec 2024
Background Rhinitis is a prevalent condition affecting individuals of all age groups, resulting from factors such as cold, nasal infections, allergies, inflammation, and sinusitis. The diverse compositions of bioactive e…
Article
Design, Fabrication and Characterization of Transdermal Patches Using Different Natural Polymers Containing Caffeine and Ibuprofen for Long-Term Management of Migraine
Muhammad Abid Mustafa, Hamza Farooq, Emaan Asif, Aqsa Saleem, Muqadas Amin, Hamna Shafiq, Alvina Shabbir, Haseeb Anwar, Mahgull Mahmood, Muhammad Shahmir Ahsan, Akifa Bashir
pp. 1192–1200 · DOI: 10.5530/ijpi.14.4.130 · Published Oct-Dec 2024
Background The study explores transdermal drug delivery as a solution to traditional oral and parenteral administration challenges, highlighting improvements in efficiency and scope with micro needle technology. Objectiv…
Article
Targeted Immunization Strategies and Designing Vaccine against Indian Nipah Virus Strain (NiV B) and Malaysian Variant (NiV M)
Naseera Kannanthodi Pariyapurath, Selvaraj Jagannathan, Maghimaa Mathanmohun, Sarika Baburajan Pillai, Kavitha Dhandapani, Rahul Gandhi Pachamuthu, Shivanandappa Kukkaler Channappa, Sivakumar Sakthivel, Hemapriya Namassivayam
pp. 1201–1207 · DOI: 10.5530/ijpi.14.4.131 · Published Oct-Dec 2024
Background Nipah virus is a deadly infectious virus that was first isolated and identified from Malaysia. Since then, a number of Nipah virus outbreaks have been reported from Bangladesh and India. Transmission of the di…
Article
Synthesis, in silico and in vitro Evaluation of 1, 3, 4-Thiadiazole Derivatives Fused with Biphenyl Compound
Faruk Alam, Josef Yakin, Subham Ghosh, Surabhi Mandal, Moidul Islam Judder, Pynshailang Dkhar, Pratyushpal Kashyap
pp. 1208–1215 · DOI: 10.5530/ijpi.14.4.132 · Published Oct-Dec 2024
Background 1,3,4-thiadiazole nucleus is a flexible nucleus. There are numerous biological activities showed by this nucleus. Anticancer, anthelmintic, antimicrobial, anti-inflammatory, antioxidant; anti-HIV, anti- tuberc…
Article
Purification and Production Optimization of Bacterial Pectinases Using Fruit Waste
Srinaina Kapilavai, Ranganadha Reddy Aluru, Chandrasekhar Chanda
pp. 1216–1220 · DOI: 10.5530/ijpi.14.4.133 · Published Oct-Dec 2024
Objectives Pectinase plays a crucial role in the commercial food processing industry by aiding in the breakdown of pectin and facilitating various processing stages like liquefaction, clarifying, and juice extraction. To…
Article
Evaluation of Antibiotics Resistance Pattern in Respiratory Tract Infections and Urinary Tract Infections in Tertiary Care Hospital
Meriga Pramod Kumar, Shaik Amrin, Chenna Reddy Vaishnavi, Butti Swapna, Pullaganti Sai Charan, Leela Prasad
pp. 1221–1225 · DOI: 10.5530/ijpi.14.4.134 · Published Oct-Dec 2024
Background The most prevalent infectious disorders are Urinary Tract Infections (UTI) and Respiratory Tract Infections (RTI), which are frequently related to morbidity and mortality. Due to improper antibiotic administra…
Article
Formulation and Evaluation of Nutraceutical Dosage Form Derived from Vigna aconitifolia, Eleusine coracana and Chenopodium quinoa
Ritu Saini, Meenakshi Bajpai
pp. 1226–1234 · DOI: 10.5530/ijpi.14.4.135 · Published Oct-Dec 2024
Background Natural products such as plants and herbs are primely opted for by the consumers these days for the treatment or mitigation of any health condition. And countless options present in our surroundings, that can …
Article
Fabrication and in vitro Evaluation of Biotin Conjugated Iron Oxide Nanoparticle for Breast Cancer Therapy
Nivetha Chitra Kandasamy, Sankar Veintramuthu, Ponpandian Nagamony, Justin Anthomy, Ramesh Santhanam, Jawahar Natarajan
pp. 1235–1241 · DOI: 10.5530/ijpi.14.4.136 · Published Oct-Dec 2024
Background Cancer is the most lethal disease in humans, accounting for one out of every six fatalities. The most frequent type of cancer among women is breast cancer, followed by cervix cancer. Iron oxide nanoparticles, …
Article
Design and Statistical Optimization of Fast-Dissolving Buccal Films of Doxylamine Succinate for Allergy Treatment
Sumitradevi Choudhary, K H Harish, Amruth M Sansthanmath, M Mahesh, Revati D Sagare, Fatima Sanjeri Dasankoppa, Agadi Hiremath Viswanatha Swamy
pp. 1242–1252 · DOI: 10.5530/ijpi.14.4.137 · Published Oct-Dec 2024
Aim and Objectives The present work aimed to prepare a FDBF with a fixed dose of Doxylamine succinate. This film provides fast relief from sudden allergic reactions. Materials and Methods FDBF were produced employing a t…
Article
Adsorption of Cephalexin Antibiotics from Aqueous Solution Using a Polypyrrole/Titanium Dioxide Nanocomposite
Niusha Hassandoost, Mobina Fotuhi, Kethineni Chandrika, Davoud Balarak
pp. 1253–1259 · DOI: 10.5530/ijpi.14.4.138 · Published Oct-Dec 2024
Background Antibiotics play a crucial role in the treatment of infectious diseases in humans and animals. However, their incomplete metabolism in the body often results in their release as active compounds into aquatic s…
Article
Targeting Breast Cancer with Dasatinib Derivatives: A Multi-Parameter Strategy to Uncover Potent Lead Compounds
Abdulaziz Mohammed Asiri, Amer Ali Ahmad Al Ali, Mohammed Haidar Abu-Alghayth
pp. 1260–1272 · DOI: 10.5530/ijpi.14.4.139 · Published Oct-Dec 2024
Background Breast cancer is the most commonly diagnosed cancer and the second most prominent cause of death in women. Owing to its intricate nature involving multiple cell types, preventing its onset is challenging. Tyro…
Article
Pharmaco-economic Evaluation of Drugs Used in Respiratory Diseases in a Tertiary Care Teaching Hospital
Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Triveni Jagadish Umarani, Sai Meghana Gummadi
pp. 1273–1278 · DOI: 10.5530/ijpi.14.4.140 · Published Oct-Dec 2024
Background Respiratory infections refer to any disease of airways and lungs which affects the respiratory system of humans. The nasal cavities, pharynx, larynx, trachea, bronchi and bronchioles, the tissues of the lungs …
Article
Pharmacist’s Evaluation of Medication Related Problems with Cancer: An Individualized Medication Assessment and Planning (iMAP) Approach
Satish Karoli, M S Ganachari
pp. 1279–1286 · DOI: 10.5530/ijpi.14.4.141 · Published Oct-Dec 2024
Background Improving outcomes for cancer patients, particularly older adults with complex health requirements, necessitates optimizing drug therapy. The Individualized Medication Assessment and Planning (iMAP) program, a…
Article
Investigating the Effect of Mixed Hydrotropy Approach on Solubility Enhancement of Felodipine
Zainab Eassa Jassim
pp. 1291–1298 · DOI: 10.5530/ijpi.14.4.143 · Published Jan-Apr 2024
Poorly soluble drugs are sources of concern in pharmaceutical formulations. Hydrotropes are compounds that enhance the solubility of insoluble materials in solvents. The hydrotropic solubilization concept is one of the m…

Case Report

Article
Macrolide Antibiotic-Induced Acute Generalized Exanthematous Pustulosis in an Epileptic Patient on Phenytoin Therapy
Guntur Prasanthi, Nagaraju Bandaru, Neredumilli Navya Sri, Swathi Nalla, Makarand Suresh Gambhire, Nallapaty Srilakshmi
pp. 1287–1290 · DOI: 10.5530/ijpi.14.4.142 · Published Oct-Dec 2024
Acute Generalized Exanthematous Pustulosis (AGEP) is a rare and severe cutaneous adverse reaction characterized by the abrupt onset of widespread sterile pustules on an erythematous base. This is associated with medicati…