Volume 15, Issue 1

Jan-Mar 2025 · pp. 1–312 · 27 articles

Volume: 15
Issue: 1
Published: Jan-Mar 2025
Pages: 1–312
Articles: 27
Sections: 2
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article

In this issue

Review Article

Review
Dendritic Cells: Crucial Regulators of Immune Responses on Cancer Cells
Tanu Raj Dulal, Deepak Kumar Jha, Saroj Kumar Sah, Mehdi Fathima
pp. 1–9 · DOI: 10.5530/jphi.20251571 · Published Jan-Mar 2025
Dendritic Cells (DCs) play a pivotal role in the immune system, acting as sentinels that capture, process and present antigens to T cells, thus initiating and regulating immune responses. Activation of DCs stands at the …
Review
Exploring Herbal Antihistaminics-Natural Allergy Fighters for Comprehensive Health Care
Puja Ganeshrao Maldhure, Anita Wanjari, Kirti Naharwal
pp. 10–18 · DOI: 10.5530/jphi.20251739 · Published Jan-Mar 2025
Histamine is found in a variety of bodily fluids, platelets, leucocytes, basophils and mast cells in the human body. Mast cells and circulating basophiles store the majority of histamine. Moreover, histamine functions as…
Review
Unlocking the Potential of Purine Analogues: A Review on Novel Anticancer Strategies
Deepika Dyapenahalli Umesh, Purushotham Karadigere Nagaraj, Likhith Kumar Karadigere, Madhu Bommenahalli Krishnegowda, Thoppalada Yunus Pasha
pp. 19–29 · DOI: 10.5530/jphi.20250020 · Published Jan-Mar 2025
Cancer is one of the world’s most prevalent causes of death; there is a constant need to find novel treatment medications with increased efficacy and reduced adverse effects. Cancer is a complex group of diseases charact…
Review
Three-Dimensional Printing of Colon-Targeting Drug Delivery Systems (CTDDS)
Fahad Raad Salim Altalib, Omar A Hamid
pp. 30–48 · DOI: 10.5530/jphi.20250057 · Published Jan-Mar 2025
In recent decades targeted drug delivery has obtained a significant interest for its ability to enhance therapeutic efficacy and reduce side effects of the drugs. Among them, colon-targeting drug delivery systems have be…
Review
Nanocochleates: Versatile Nanostructures for Enhanced Drug Delivery and Therapeutics
Kaviya Suresh, Devasena Srinivasan, Venkatesan Palanivel, Anbarasan Balu
pp. 49–56 · DOI: 10.5530/jphi.20250082 · Published Jan-Mar 2025
Nanocochleates, lipid-based nanostructures inspired by the cochlea’s spiral structure, have developed as talented candidates for advanced drug delivery systems and therapeutic applications. Their special design, which co…
Review
Crispr Revolution: Cutting-Edge Biosensors and Nanomedicine for Precision Health
Mahalakshmi Devaraji, Lokeshvar Ravikumar
pp. 57–66 · DOI: 10.5530/jphi.20251769 · Published Jan-Mar 2025
In recent years, biomedical research has resulted in innovative methods for precisely altering genomes, advancing personalized diagnostics and therapeutics through genetic engineering. The Clustered Regularly Interspaced…
Review
Advances in Co-Processed Excipients: Multifunctional Platforms for Diverse Pharmaceutical Formulations
Hellen Yayra Dzoagbe, Anup Sanjay Shende, Mujibhullah Sheikh, Mrunal Deshmukh
pp. 67–77 · DOI: 10.5530/jphi.20251862 · Published Jan-Mar 2025
As it adds so many advantages to the finished formulations, excipient utilised in pharmaceutical dosage forms is a special and important ingredient that is just as important as the API. Improving API absorption and bioav…
Review
Health Entrepreneurship in Pharmacy: Exploring Success Stories from South Asian Countries
MFF Rukshana, Mudiyanselage Imalka Upamali Kumari Tennakoon
pp. 78–85 · DOI: 10.5530/jphi.20251792 · Published Jan-Mar 2025
Health entrepreneurship has emerged as a dynamic force shaping the landscape of healthcare delivery, with a particular focus on the pharmaceutical sector. This mini-review aims to investigate and present success stories …
Review
Tumor Microenvironment-Different Cells and Functions in the Metastasis and Progression of Cancer
Maryam Musleh Althobiti
pp. 86–102 · DOI: 10.5530/jphi.20250002 · Published Jan-Mar 2025
Major molecular, physical as well as cellular changes inside their host tissues are enthused by the tumor cells. The evolving TME is an active and multifaceted system. The structure of the TME differs amongst the categor…

Original Article

Article
Improving Transdermal Donepezil Delivery: A Comprehensive Design Expert Screening Method for a Dependable supply in Alzheimer’s Disease Management
Bariki Rajasekhar, Haranath Chinthaginjala
pp. 103–112 · DOI: 10.5530/jphi.20251733 · Published Jan-Mar 2025
INTRODUCTION The benefit of systemic Donepezil absorption by transdermal patches is that they avoid hepatic first-pass metabolism. They make it possible for drugs to be gradually and carefully released into the bloodstre…
Article
Synthesis Characterisation in silico Studies and Anti-bacterial Evaluation of Acetaminophen Chalcone Derivatives
Ramakrishna Chintakunta, Lalitha Suresh, Rutushree Amar, Nisarga Mahadevaiah, Lisha Mallesh, S Jeevan Prasad
pp. 113–121 · DOI: 10.5530/jphi.20251753 · Published Jan-Mar 2025
Background Design synthesis of Acetaminophen-chalcone conjugates and finding the in silico studies and characterisation of compounds. Determination of biological activity mainly emphasise on Antibacterial activity. Chalc…
Article
Elevating Therapeutic Potential: Levofloxacin-Loaded Ocular Films for Conjunctivitis Management
Repollu Maddileti, Haranath Chinthaginjala
pp. 122–130 · DOI: 10.5530/jphi.20251755 · Published Jan-Mar 2025
Background The study aimed to develop ocular films containing levofloxacin to treat conjunctivitis. These films were meticulously prepared using a combination of Gelatin, Aloe barbadensis leaves mucilage, and HPMC K4M, b…
Article
Clinical Pharmacist-Initiated Interventions for Medication-Related Problems in the Medical Intensive Care Unit of a Teaching University Hospital in South India: A Prospective Observational Study
Neelima Ganzi, Savitha Rajapur Sanathan, Subhash Chandra Ballekere Jayaram, Easwaran Vigneshwaran
pp. 131–137 · DOI: 10.5530/jphi.20251760 · Published Jan-Mar 2025
Background Medical Intensive Care Unit (MICU) admitted patients have complex drug regimens, serious underlying diseases which increase the risks of Medication-Related Problems (MRP). The study aims to identify, character…
Article
QBD-Based Optimization and Formulation of Doxorubicin Bcl-2 SIRNA-Loaded Sphingosomes
Prashant Nayak, Rompicherla Narayana Charyulu, Alandur Veena Shetty
pp. 138–158 · DOI: 10.5530/jphi.20251766 · Published Jan-Mar 2025
Background By increasing drug stability and water solubility, cycle duration, rate of absorption into target cells or tissues, and reducing enzymatic degradation, Nano Drug Delivery Systems (NDDS) improve the safety and …
Article
Analytical Method Development and Validation of Efavirenz by Using RP- HPLC
Ishu Tyagi, Kandasamy Nagarajan, Snigdha Bhardwaj
pp. 159–169 · DOI: 10.5530/jphi.20251789 · Published Jan-Mar 2025
Background Efavirenz is a widely used antiretroviral medication for managing HIV infection, known for its role as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). By targeting and inhibiting the reverse transcri…
Article
Recent Advance Docking Sites of Novel Phenothiazine’s Derivative on G Protein-Coupled Receptors (GPCRs) against Depression with Monoamine Oxidase (PDB ID: 2BXR)
Sanket Keshav Tambe, Rohit Jaysing Bhor, Shubham Balasaheb Mhaske, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Neha Shyam Bora, Vaijanti Ashok Medge, Akanksha Kailas Nirmal
pp. 170–181 · DOI: 10.5530/jphi.20251795 · Published Jan-Mar 2025
Background GPCRs are among the most effective therapeutic target families. They have undergone a transition from ligand screening at random to knowledge-driven drug design. We are seeing first-hand the enormous strides l…
Article
Synthesis, Characterization and Attenuation of Strychnine-Induced Epilepsy on 3-(3-Aminophenyl)- 1-[3-(2-Hydroxyphenyl)-3-Oxopropanoyl]-5,5-Diphenylimidazolidine-2,4-Dione Derivatives on Experimental Rats
Mayur Sitaram Gaikwad, Rohit Jaysing Bhor, Mahesh Hari Kolhe, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Neha Shyam Bora, Vaijanti Ashok Medge, Akanksha Kailas Nirmal
pp. 182–190 · DOI: 10.5530/jphi.20251804 · Published Jan-Mar 2025
Background It was a heterocyclic hydrocarbon whose molecular structure has some fundamental structural features. In this study, we synthesise eleven different imidazolidine-2,4-dione derivatives that have convulsive prop…
Article
Synthesis and Characterization of Halo-Indole Derivatives Reveal Improved Therapeutic Agents for Treatment of Inflammations
Rohit Jaysing Bhor, Harshada Sudhakar Aher, Sanket Keshav Tambe, Mahesh Hari Kolhe, Neha Shyam Bora, Vaijanti Ashok Medge, Pruthviraj Vijay Kute, Pratik Vijay Malvade, Jyoti Ramkisan Bhagat, Poonam Prakash Waykar, Vinod Rajendra Tawate, Tejaswini Bharat More, Akanksha Kailas Nirmal
pp. 191–198 · DOI: 10.5530/jphi.20251822 · Published Jan-Mar 2025
Background Five-membered heterocycle with one neighbouring nitrogen atoms is present in the indole nucleus. Heterocyclic substances feature two adjacent benzene and pyrrole ring atoms. Indoles are heterocyclic compounds …
Article
Investigation of Black and Brown Rice as Inhibitors of Tyrosinase and Xanthine Oxidase Enzymes: An in vitro and in silico Investigation
Taranga Jyoti Baruah, Sanathoi Tongbram, Pratyashi Bora, Shivani Priya, Langlen Meinam, Sanjenbam Kabita
pp. 199–208 · DOI: 10.5530/jphi.20251798 · Published Jan-Mar 2025
Background Xanthine oxidase and tyrosinase are enzymes involved in various functions in the body. Tyrosinase and xanthine oxidase have high activity levels in various diseases like gout hyperpigmentation and neurodegrada…
Article
Pharmaceutical Manufacturing Sectors Regulatory-Based Operation Management for Parenteral Preparations
Palanisamy Pethappachetty, Kavya Thirupathi, Phagalavan Moorthy, Mohan Kumar, Manivasakam Prakash, Anandharaj Govindharaj
pp. 209–218 · DOI: 10.5530/jphi.20251622 · Published Jan-Mar 2025
Aim/Background This research explores the pharmaceutical industry’s operations management, focusing on regulatory-based operation management for parenteral preparations. Materials and Methods The study utilizes a compreh…
Article
Revolutionizing Herbal Medicine: The Role of E-health Informatics and Network Pharmacology in Personalized Herbal Therapies
Bachunaga Kishore Babu
pp. 219–227 · DOI: 10.5530/jphi.20251754 · Published Jan-Mar 2025
Aim The purpose of this study is to investigate how network pharmacology and e-health informatics affect the effectiveness and personalization of herbal treatments, while also discussing related issues and potential futu…
Article
Determination of Antioxidant and Anti-inflammatory Potentials of Selected Therapeutic Plants Aqueous Extract and their Formulation for Wound Healing
Satish Dubey, Jagriti Chandrakar, Shilpa Vinodia, Ashwini Kumar Dixit
pp. 228–236 · DOI: 10.5530/jphi.20251847 · Published Jan-Mar 2025
Background Since ancient times, medicinal plants with antioxidant and anti-inflammatory abilities have been utilized for relieving a variety of health problems. Individual herbs, however, are inadequate to provide the ne…
Article
Anti-Inflammatory Activity Potential of Arglabin in LPS-Stimulated RAW 264.7 Macrophages
Faiz Abdulaziz Alfaiz
pp. 237–247 · DOI: 10.5530/jphi.20250059 · Published Jan-Mar 2025
Background Uncontrolled inflammation, however, adds to the pathophysiology of many chronic diseases even though it is a vital defense mechanism in health. Despite being necessary for reducing inflammation, anti-inflammat…
Article
Drugs Recommended by Pharmacy Professionals in “Real Life” Pharmaceutical Practice
Maria Sergeevna Soboleva
pp. 255–264 · DOI: 10.5530/jphi.20250065 · Published Jan-Mar 2025
Introduction Most studies of pharmaceutical consultation are aimed at assessing the satisfaction of visitors with the service provided, while its information part is not paid enough attention. Purpose The analysis of dru…
Article
Formulation and Optimization of Fast Dissolving Buccal Films of Hydralazine HCl Using Design Expert Software
S P Hiremath, Amruth M Sansthanmath, K P Manjunath, Sumitradevi Choudhary, Prajwal Sunil Kole, Gouri Santosh Koshti, Anisha Anandu Shetiya, M Mahesh
pp. 265–276 · DOI: 10.5530/jphi.20251728 · Published Jan-Mar 2025
Aim and Objectives This study aimed to design and optimize Fast-Dissolving Buccal Films (FDBF) containing Hydralazine HCl, with the goal of developing an effective treatment for hypertension. Materials and Methods Solven…
Article
Development and Characterization of Telmisartan-Loaded Nanosuspension for Enhanced Drug Delivery
Sanjeev Kumar, Tanveer Naved, Sanjar Alam, Reeta Chauhan
pp. 295–302 · DOI: 10.5530/jphi.20251391 · Published Jan-Mar 2025
Background In this exploration, the aim was to devise and delineate a nanoscale suspension of telmisartan directed at enhancing drug delivery efficiency. Materials and Methods The process entailed formulating telmisartan…
Article
In vitro Evaluation of the Antioxidant and Anticancer Activities of Acetone and Methanolic Extracts of Asparagus racemosus in Human Cervical Cancer Cell Lines (HeLa Cells)
Gopal Viraj Koundinya Vutukuru, Gnaneshwar Reddy Kontham, Kalyani Chepuri, Pranitha Chittepu, Harikrishna Kathuroju, Geethikalal Vadakavila, Uma Addepally, Sesha Srinivas Vutukuru
pp. 303–312 · DOI: 10.5530/jphi.20250108 · Published Jan-Mar 2025
Background Cervical cancer is the fourth most common cancer among women across the globe. Typically, it is treated by Cisplatin in combination with radiation therapy, which has side effects. We evaluated the phytochemica…