Volume 15, Issue 2

Apr-Jun 2025 · pp. 313–674 · 33 articles

Volume: 15
Issue: 2
Published: Apr-Jun 2025
Pages: 313–674
Articles: 33
Sections: 2
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article

In this issue

Review Article

Review
A Comparative Review of 3D Printing Technologies and their Applications: A Systematic Review for Future of Medicine Fabrication
Muhammad Abid Mustafa, Aqsa Malik, Eman Javed, Aliza Amjad, Sana Iqbal, Eman Mustafa, Namra Rasheed, Aqsa Shafiq, Muhammad Fahad, Maryam Mughal, Gohar Jaan, Nageen Ramzan
pp. 313–324 · DOI: 10.5530/ijpi.20250024 · Published Apr-Jun 2025
This review explores the role of additive manufacturing, particularly 3D printing, as an innovative approach in targeted drug delivery. It effectively addresses the limitations of traditional methods, such as high costs,…
Review
Precision Medicine in Diabetes Management: From Theory to Clinical Practice
K N Pooja, D R Bharathi, Syed Sagheer Ahmed, B M Jayanth, K Chandan
pp. 325–333 · DOI: 10.5530/ijpi.20250047 · Published Apr-Jun 2025
Precision medicine in diabetes management is a groundbreaking approach that tailors treatment strategies to individual patients, moving beyond the one-size-fits-all model. It leverages genetic, molecular and lifestyle da…
Review
Revolutionizing Healthcare: The Impact of AI on Precision Medicine
Lakshmi Prasanthi Nori, Maddala Lohitha, Rama Rao Vadapalli, Brahmaiah Bonthagarala, Sudarshan Rao Nagineni, Venkateswara Raju Kalidindi
pp. 334–360 · DOI: 10.5530/ijpi.20250100 · Published Apr-Jun 2025
Artificial Intelligence (AI) is ushering in a transformative era for personalized medicine by customizing therapeutic interventions based on individual patient profiles, including genetic information and environmental in…
Review
Review on Soluplus®: Pharmaceuticals Revolutionizing Drug Delivery and Formulation Strategies
Kamalesh Dilip Mali, Durgesh Tulshiram Shinde, Kalpesh Ravindra Patil
pp. 344–360 · DOI: 10.5530/ijpi.20250146 · Published Apr-Jun 2025
Solubility enhancers are one way to get around the difficulties with medication absorption and dissolution in oral drug delivery, since many novel active pharmaceutical components are not well soluble in water. The effic…
Review
Pharmaceutical Excipients: Functions, Selection Criteria, and Emerging Trends
Saniya Makkad, Mujibullah Sheikh, Sanskruti Shende, Pranita Jirvankar
pp. 361–376 · DOI: 10.5530/ijpi.20251676 · Published Apr-Jun 2025
Pharmaceutical excipients are integral to therapeutic formulations; their importance has grown from inert and economical materials to components that make up 80-90% of the finished product. This review examines the excip…
Review
Review on Nanoemulsion Based Nanogel for Fungal Infection
Sanjiv Kumar Gupta, Neelesh Chaubey
pp. 377–387 · DOI: 10.5530/ijpi.20251793 · Published Apr-Jun 2025
Nanoemulsion-based nanogels have emerged as a promising approach for treating fungal infections due to their unique properties. Nanoemulsions are fine oil-in-water or water-in-oil dispersions stabilized by surfactants, c…

Original Article

Article
Determination of Momelotinib in Rat Plasma by LC-MS/MS: Application to Pharmacokinetics Study
Bysani Suresh Babu, Nalanda Revu Baby, Sumanta Mondal
pp. 388–396 · DOI: 10.5530/ijpi.20250004 · Published Apr-Jun 2025
Objectives This study describes developing and validating a novel method using LC-MS/ MS to measure the concentration of Momelotinib in rat plasma. Materials and Methods The pharmacokinetic applicability of the process w…
Article
Evaluation of the Multifaceted Impact of Hypothyroidism on Metabolic Components and Quality of Life
Bipin Shaji, Juno Jerold Joel, Raghava Sharma, Shraddha Shetty
pp. 397–406 · DOI: 10.5530/ijpi.20250019 · Published Apr-Jun 2025
Background Hypothyroidism is characterized by an underactive thyroid gland. As thyroid hormones are essential for regulating metabolism, disruptions in secretions can cause metabolic syndrome. This study is to assess the…
Article
KAP Analysis of the Materiovigilance Programme: A Comparative Study between M.Pharm and D.Pharm Students
Shamita Shyam Sail, Akshata Gore, Arfa Anwar Sayed, Mohd Ramish Khan, AHM Viswanatha Swamy, BM Dayana, Sanatkumar Bharamu Nyamagoud
pp. 407–416 · DOI: 10.5530/ijpi.20250035 · Published Apr-Jun 2025
Background Materiovigilance is important for checking the safety and effectiveness of medical devices. There isn't much research on how pharmacy students understand and perceive about materiovigilance. To understand this…
Article
Green Synthesis, Characterization and Bioactivity of AuNPs from E. cardamomum: A Comparative Study
KM Sowmya, RT Narendhirakannan
pp. 417–433 · DOI: 10.5530/ijpi.20250039 · Published Apr-Jun 2025
Background Nanoparticles, particularly those from natural sources like E. cardamomum, have garnered significant interest due to their unique physicochemical characteristics and potential applications in medicine. Materia…
Article
Microwave-Assisted Synthesis of Benzaldehyde Derivatives and their Biological Activity
Prasad Dilip Kadam, Ganpat Ram Nagargoje, Abhay Shivajirao Bondge, Kalimoddin Inayatsab Momin, Sharad Pandit Panchgalle, Vijaykumar Shivdas More
pp. 434–442 · DOI: 10.5530/ijpi.20250040 · Published Apr-Jun 2025
Background The study focuses on the synthesis of novel 4-Hydrazinyl-7H-Pyrrolo[2,3-d] Pyrimidine (HPP) derivatives using microwave-assisted synthesis starting from substituted benzaldehydes (a-j) and HPP in the presence …
Article
Formulation and Evaluation of Darunavir Ethanolate Nanogel as Microbicide in Pre-Exposure Prophylaxis for HIV Infection
Mithun Bandivadekar, Ashwini Madgulkar, Syed Mubashir Rashid, Ranjitkumar Padakanti, Vedanti Godbole
pp. 443–453 · DOI: 10.5530/ijpi.20250042 · Published Apr-Jun 2025
Background Anti-retroviral drugs are challenging formulation scientists due to their poor solubility problem. This criticality increases when the drug has to be delivered by a vaginal route where the availability of flui…
Article
Computational Docking Study of Oxazepine Based Compounds as Inhibitors of Acetylcholinesterase Enzyme in Alzheimer’s Disease
Aneesha Addanki, Rama Rao Nadendla, Vijaya Kishore Kanakaraju
pp. 454–461 · DOI: 10.5530/ijpi.20250068 · Published Apr-Jun 2025
Background Alzheimer's disease has become a serious health problem in recent years. Certain acetylcholinesterase inhibitors have been shown to have anti-Alzheimer's properties. In the current work, a number of oxazepine …
Article
Comparative Phase Solubility Analysis of Olanzapine by 24 Optimization Techniques with Different Water-Soluble Carriers
Revathi Sundaramoorthi, Anitha Pavadai, Jenifer Sathappan, Senthil Rajan Sivakumar
pp. 462–470 · DOI: 10.5530/ijpi.20250074 · Published Apr-Jun 2025
Background The solubility of medications significantly affects their absorption and therapeutic effectiveness. Drugs with poor solubility often faces challenges in formulation development leading to low bioavailability a…
Article
Neuroprotective and Anti-Apoptotic Activity of Anthranilamide Pyrazolo[1,5-a] Pyrimidine Derivative against Parkinson’s Disease Model in Rotenone-Induced SH-SY5Y Cells
Suresh Yerramsetty, Lavanya Ayyagari, Venkata Krishna Kanth Makani, Jolly Janette Mendonza, Suchitra Maheswari Ajjarapu, Ahmed Kamal, Smita C. Pawar, Manika Pal Bhadra
pp. 471–481 · DOI: 10.5530/ijpi.20250079 · Published Apr-Jun 2025
Parkinson’s Disease (PD) is the second most prevalent form of neurodegenerative disorder distinguished by progressive and specific loss of dopaminergic neurons in the Substantia Nigra (SNPc) resulting in abnormal movemen…
Article
Optimizing Leflunomide Embedded Microsponge Gel for Effective Topical Application
Dipti Gohil, Ujjaval Patel, Priyank Patel, Nirmal Shah, Sunil Kardani
pp. 482–489 · DOI: 10.5530/ijpi.20250086 · Published Apr-Jun 2025
Background Rheumatoid arthritis causes chronic joint pain and inflammation, significantly impacting quality of life. Current treatments are limited, with oral Leflunomide commonly used. However, prolonged oral administra…
Article
A Sunscreen Based on Avobenzone Loaded in Solid Lipid Nanoparticles for Enhanced Sun Protection
Jawahar Natarajan, Pavalan Krishnan, Sebatini Sinsi Arokianathan, Sharuni Sivakumar, Parish Vendar Saravanan, Roshan Prasad Rao
pp. 490–497 · DOI: 10.5530/ijpi.20250087 · Published Apr-Jun 2025
Objectives Sunscreen cosmeceuticals play a crucial role in protecting the skin from dangerous ultraviolet radiation, which is linked to various dermatological diseases and skin cancers. Avobenzone is extensively used org…
Article
Natural and Synthetic Polymer-Based Transdermal Patch Formulation for Bosentan: Development and in vitro Evaluation
Balakrishna Talamanchi, Lakshman Kumar Dogiparthi, Bala Sree Sanjeevi Pusala, Roshni Patan, Vamsi Abhiram Yadlapalli, Vinay Simhadri, Shahid Hussain Shaik, Yasaswini Vakkalagadda
pp. 498–507 · DOI: 10.5530/ijpi.20250095 · Published Apr-Jun 2025
Introduction The goal of this study was to develop and evaluate Bosentan transdermal patches for the treatment of Pulmonary Arterial Hypertension (PAH), which is defined as an abnormally high blood pressure in the arteri…
Article
Stability Demonstrating Validated High-Pressure Liquid Chromatographic Method for the Simultaneous Determination of Levodopa and Benserazide
Sunil Rayudu, Medikonda Manoranjani, D Anitha
pp. 516–523 · DOI: 10.5530/ijpi.20250109 · Published Apr-Jun 2025
Background An accurate, rapid, inexpensive, and straightforward, reliable simultaneous assay technique was developed and demonstrated to evaluate Levodopa and Benserazide using RP-HPLC. Materials and Methods The suggeste…
Article
Optimizing Encorafenib Validation: A Quality by Design Approach Empowered by Green Chemistry
Diptimayee Jena, Asra Jabeen, Akash Deep Mahato, Khush Choudhary, Roshan Mahato, Pakhi Chakraborty, Kirtimaya Mishra
pp. 524–530 · DOI: 10.5530/ijpi.20250120 · Published Apr-Jun 2025
Background Green chemistry, also known as environmentally sustainable chemistry, is an area of study within a field of chemistry with the main goal of reducing the negative effects associated with chemical reactions and …
Article
Mechanistic Insight and Inhibitory Potential of Fluvastatin-Derivatives against Dyslipidemia
Ali Mahzari, Eman H. Khalifa, Ali A Zaeri, Hanan E Alyahyawi, Wanian M Alwanian, Saad M. Wali, Ohood Almuzaini, Yazeed Alshuweishi
pp. 531–542 · DOI: 10.5530/ijpi.20250138 · Published Apr-Jun 2025
Background Cardiovascular diseases comprehend a array of situations that disturb the heart and blood vessels, making them a principal cause of morbidity and mortality worldwide. Dyslipidemia, an imbalance in lipids, such…
Article
Green Synthesis of Gold Nanoparticles from Aegle marmelos Extract: Evaluation of Antioxidant, Anti-inflammatory and Anticancer Properties
S Mrudhulla, R.T Narendhirakannan
pp. 543–561 · DOI: 10.5530/ijpi.20250143 · Published Apr-Jun 2025
Background Aegle marmelos, commonly known as bael, is a medicinal plant native to India with well-established use in traditional medicine systems. Materials and Methods This study aims to evaluate the antioxidant, anti-i…
Article
A Pharmacovigilance Study on Adverse Drug Reaction Profile at a Tertiary Care Teaching Hospital from Western Part of India
Nirali Doshi, Bijal Prajapati, Lavanya Selvaraj
pp. 562–572 · DOI: 10.5530/ijpi.20250144 · Published Apr-Jun 2025
Background Pharmacovigilance studies analyzing Adverse Drug Reactions (ADRs) play a crucial role in understanding the ADR profile at tertiary care centers. The objective of this study is to identify, analyze and understa…
Article
Factors Effecting Parental Knowledge Regarding their Child Immunizations: An Observational Study from Lahore, Pakistan
Sara Shahid, Maryam Ayesha, Muhammad Fahad, Maryam Mughal, Areej Kainat, Hamda Shakir, Muhammad Ali Tahir, Ansa Ijaz, Qurat-ul-Ain, Saad Saeed Alqahtani, Muhammad Zahid Iqbal
pp. 573–582 · DOI: 10.5530/ijpi.20250152 · Published Apr-Jun 2025
Background A significant number of parents lack knowledge about vaccine-preventable diseases and hold misconceptions regarding the components, side effects and effectiveness of vaccines. A lack of understanding regarding…
Article
Development and Validation of a UV Spectrophotometric Method for Almotriptan Malate Estimation in Bulk and Niosomal Formulation
Shweta Sulakude, Nisha Shirkoli
pp. 583–591 · DOI: 10.5530/ijpi.20250153 · Published Apr-Jun 2025
Background Almotriptan Malate is a selective serotonin receptor agonist developed for migraine management in adults. Its bioavailability is 69.1%, with an elimination half-life of 3 hours and has low aqueous solubility. …
Article
Super-Saturated SNEDDS with Vegetable Oils: Formulation and Evaluation
Heena Mittal, Sudhakar Kaushik, Bhawana Bhatt, Assem Babbar
pp. 592–603 · DOI: 10.5530/ijpi.20250154 · Published Apr-Jun 2025
Background Solubility is the most vital parameter in the formulation of different drug delivery systems and one of the core concepts of the formulations. More than 50% of the new drug molecules are facing poor solubility…
Article
Identification of a Potential Compound against Drug Resistant Strain of Mycobacterium tuberculosis Using in silico Methods
Monish Mukul Das, Sayan Chakraborty
pp. 604–613 · DOI: 10.5530/ijpi.20250155 · Published Apr-Jun 2025
Background Uninterrupted spread of drug-resistant tuberculosis has necessitated prioritization of new and effective antitubercular compound. This investigation aimed to apply in silico methods to find out potential inhib…
Article
Computer-Assisted Prediction of Drug-Like Properties of Selected Phytochemicals from Terminalia chebula
Adarsh Arun Patil, Shailendra Sanjay Suryawanshi
pp. 614–630 · DOI: 10.5530/ijpi.20250067 · Published Apr-Jun 2025
Introduction The growing focus on natural products in drug discovery has led to a deeper investigation of phytochemicals from traditional medicinal plants. Terminalia chebula, known for its broad range of therapeutic use…
Article
Formulation Development of Tofacitinib Niosomes Using Design of Experiments
K. Lalitha, M.P. Kusuma
pp. 631–641 · DOI: 10.5530/ijpi.20250116 · Published Apr-Jun 2025
Background Tofacitinib Citrate (TCB) is a selective Janus kinase inhibitor approved by the USFDA for the treatment of Rheumatoid arthritis. However, TCB faces extensive first pass metabolism and causes GI trouble on oral…
Article
Dermal Safety Study and Antifungal Activity of Dhatrayadi lepa
Satish Kumar Dewangan, Shrikant R Inchulkar, Sangeeta Bhagat, Trilochan Satapathy, Nagendra Singh Chauhan
pp. 642–649 · DOI: 10.5530/ijpi.20250151 · Published Apr-Jun 2025
Background Agad Tantra deals with poison and its manifestation, investigation, and treatment. It also deals with medicine having poisonous ingredients which always needs to be evaluated for its toxicity. In India the dru…
Article
Synergistic Antidepressant Effect of Ginkgo biloba and Withania somnifera Using Experimental Animals
Vinod Ashokdas Bairagi, Rutika Mahendra Kharnare, Kajal Satish Nikam, Yogesh Suresh Ahire
pp. 650–656 · DOI: 10.5530/ijpi.20250013 · Published Apr-Jun 2025
Aim This study involved the antidepressant activity of Ginkgo biloba and Withania somnifera in mice. Depressive disorder is a prevalent psychiatric Condition, affecting 21% of the global population. The currently used dr…
Article
Evaluation of Health-Related Quality of Life in Patients with Heart Diseases at a Tertiary Care Hospital
Rakshita Paladi, Srajana Shetty, Sachin Basavaraj, Pratik Naveenkumar Magadum, Shashidhar Mallikarjun Javali, Shivmantesh Ashok Kittur, Veeresh Hubballi, Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Vishwanath Swamy
pp. 657–663 · DOI: 10.5530/ijpi.20251868 · Published Apr-Jun 2025
Background Cardiovascular diseases damage the heart and blood arteries. Cardiovascular disorders account for 31% of all fatalities worldwide, ultimately resulting in death, according to the WHO. A blood clot (thrombosis)…
Article
Method Development and Validation of Gramicidin, Neomycin and Triamcinolone Acetonide Related Substances and their Impurities Quantification through UPLC
Ibrahim Baje Syed, Madhavi Nannapaneni
pp. 664–674 · DOI: 10.5530/ijpi.20251515 · Published Apr-Jun 2025
Aim/Background To develop and validate a sensitive, accurate, simple, precise and cost-effective receptive and understandable method for concurrent evaluation of Gramicidin, Neomycin and Triamcinolone acetonide and their…