Volume 15, Issue 3

Jul-Sep 2025 · pp. 675–1061 · 43 articles

Volume: 15
Issue: 3
Published: Jul-Sep 2025
Pages: 675–1061
Articles: 43
Sections: 4
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Research Article Original Article Short Communication

In this issue

Review Article

Review
Exploring the Healing Paths: Navigating Complementary and Alternative Medicine
Lakshmi Prasanthi Nori, Jyothirmai Malla, Rama Rao Vadapalli, Brahmaiah Bonthagarala, Praveen Kumar Dannaram, Kalidindi Venkateswara Raju
pp. 675–688 · DOI: 10.5530/ijpi.20250137 · Published Jul-Sep 2025
Due to the imbalanced patient-to-healthcare professional ratios, the increased workload for those who provide care, different adverse reactions of modern medicine, the inability to completely cure long-term ailments, exp…
Review
A Pathway to Natural Cancer Therapy; Exploring Zerumbone’s Multitargeted Anticancer Actions
Akram Ahmed Aloqbi
pp. 689–697 · DOI: 10.5530/ijpi.20250217 · Published Jul-Sep 2025
Background A compound called zerumbone found in gingers rhizome has demonstrated potential in fighting cancer due to its beneficial effects on the body. This thorough examination delves into how zerumbone works to combat…
Review
The Prevalence of Kounis Syndrome and COVID-19 Vaccination-A Comprehensive Review
Bhavya Ekambaram, Swetha Suresh, Jerphene Franklin John, Nithish Kumar Jothi Kamaraj
pp. 698–702 · DOI: 10.5530/ijpi.20250210 · Published Jul-Sep 2025
Background Kounis Syndrome (KS) or allergic myocardial infarction is a rare, complicated Coronary Artery syndrome (CAD) which develops concurrently with an allergy or hypersensitivity reaction. It is also termed as Aller…
Review
Exploring the Potential of Gastro Retentive Drug Delivery Systems: An Insightful Perspective
Saket Mishra, Priyanka Shukla, Deshraj Shyamkant Chumbhale, Pijush Dutta, Dhakshnamoorthy Vellingiri, Ruchi Tiwari
pp. 703–724 · DOI: 10.5530/ijpi.20250244 · Published Jul-Sep 2025
In today’s modern world, there is a rapid increase in the control and systemic administration of drugs through the oral route, because of its various advantages like high patient compliance, easy dose administration and …
Review
Innovative Approaches for the Extraction, Purification, and Quantification of Polyphenols: A Comprehensive Review
Netala Silvia, Atla Srinivasa Rao, Yalla Kranthi, Gangolu Yohan, Darisi Saketh, Gajula Meghamala, Kolli Prabhanjan Kumar
pp. 725–739 · DOI: 10.5530/ijpi.20250192 · Published Jul-Sep 2025
Polyphenols are one of the well-known phytochemicals and exist as secondary metabolites in natural products and show numerous physiological effects in all the living organisms due to the presence of simple phenols, aroma…
Review
Regulatory and Quality Aspects of Bio Absorbable Bandages for Intestinal Wound Healing
Vivek Reddy Murthannagari, Jeswanth Raj Nagarajan, Ganesh Gonna Nandi Krishnan, Karthikesavan Ponmurugesan, Hemalatha Thavani Devaraj, Krushika Jani
pp. 740–747 · DOI: 10.5530/ijpi.20250202 · Published Jul-Sep 2025
Surgical intestinal wound healing is a significant cellular process managed by several cellular and molecular factors. The present review aims to focus on the evolution of medical device bandages that can help improve th…
Review
A Variety of Bioactive Compounds can be found in the Spice and Medicinal Herb Trigonella foenum-graecum plant
S Revathy, R Nathiya, K Shoba
pp. 748–752 · DOI: 10.5530/ijpi.20250185 · Published Jul-Sep 2025
The annual plant fenugreek (Trigonella foenum graecum), which is indigenous to southern Europe and Asia, has white blossoms and hard, yellowish brown, angular seeds. It has long been valued for its nutritional content in…
Review
HPV Vaccines: Types, Effectiveness and Safety-A Comprehensive Review
T C Swathi Ramesh, Savitha R Sanathan, S S Kiron, M S Srikanth
pp. 753–758 · DOI: 10.5530/ijpi.20250232 · Published Jul-Sep 2025
The development of the HPV vaccine represents a groundbreaking achievement in the history of vaccine research. These vaccines, a pioneering category, effectively prevent infection by sexually transmitted microorganisms t…
Review
Quantum Dots in Nanotechnology: Advances in Therapeutics, Drugs Delivery and Imaging
Buchaiahgaripalli Yamuna, Vepamani Siva Sai Bharath Kumar, Kateregga Ismael, Nawaz Mahammed, Sabbella Sameera Reddy, Sunkesula Shahid, Gangaigari Sowmya, Lingala Tharun Kumar Reddy, Bellam Raj Kumar
pp. 759–769 · DOI: 10.5530/ijpi.20250248 · Published Jul-Sep 2025
Quantum Dots (QDs), semiconductor nanoparticles, exhibit unique optical properties like excellent photostability, high brightness, and size-tuneable emission wavelengths due to quantum confinement. Their broad absorption…
Review
Targeted Lipid Based Vesicles as Drug Delivery Systems in Cancer Treatment
Narendra Pentu, Gaddam Namitha, Kalluru Udaya Chandrika, Kolapuri Abhinav Ram, Venkata Rajesham Vallala, Ashok Morsu, Tadikonda Rama Rao
pp. 770–776 · DOI: 10.5530/ijpi.20250171 · Published Jul-Sep 2025
Cancer is not a single disease, it is a multifaced malignant tumor, having ability to develop in any part of our body and it can spread to the distant regions with the high-end cell proliferation within short duration of…
Review
Vonoprazan: A Novel Potassium-Competitive Acid Blocker in the Management of H. pylori Infection and Acid-Related Disorders
Shilpa Clara Joseph, Ramaswamy Subramanian, Shiva Prasad, Mahabaleshwar Mamadapur
pp. 777–782 · DOI: 10.5530/ijpi.20250264 · Published Jul-Sep 2025
Background Vonoprazan is a novel PCAB and the first in its class to receive US FDA approval for the treatment of H. pylori infection and gastric acid-related disorders. It binds directly to the proton pumps, blocking the…
Review
Oral Mucositis in Cancer Care: Current Insights and Future Directions from a Systematic Review
Deepak Kumar Jha, S. Manasa, Kusu Susan Cyriac, Raveena Shree R
pp. 783–792 · DOI: 10.5530/ijpi.20250174 · Published Jul-Sep 2025
Oral Mucositis (OM) is a painful inflammation often resulting from cancer therapies like chemotherapy and radiotherapy. OM manifests as ulcers that can make eating and speaking difficult and increase infection risk. Curr…
Review
Antibody-Drug Conjugates vs. Traditional Biologics: A Comparative Analysis of Rheumatic Disease Management
Mujibullah Sheikh, Pollob Roy, Pranita Jirvankar
pp. 809–822 · DOI: 10.5530/ijpi.20250203 · Published Jul-Sep 2025
The review article deals with the possibility of the use of Antibody-Drug Conjugates (ADCs) for the treatment of rheumatic diseases. The introduction emphasizes the difficulty of chronic autoimmune diseases’ management a…
Review
A Comprehensive Review Focused on the Whole Systems of the Soft Robotics, its Design Strategies and Outlook on the Future Considerations for the Soft Robots
Molika Malpani, Pranita Jirvankar
pp. 823–836 · DOI: 10.5530/ijpi.20250239 · Published Jul-Sep 2025
Soft robotics is a rapidly emerging area in healthcare and biomedical applications due to recent developments in functional materials and fabrications. This review will focus on the position that soft robotics have in me…
Review
Nanoscale Formulations for Targeted Drug Delivery: Enhancing Stability, Release Control and Therapeutic Efficacy
Lokeshvar Ravikumar, Ramaiyan Velmurugan, Patibandla Jahnavi, Pradeep Vidiyala, J Pavan Kumar, A Rahul, P Bhuvaneshwaran
pp. 837–848 · DOI: 10.5530/ijpi.20250189 · Published Jul-Sep 2025
The present study focuses on the nanoscale formulation technique for pharmacological agent delivery, avoiding the shortcomings of conventional protocols, such as rapid pharmaceutical clearance, limited site-specific accu…
Review
An Insight into Polymeric Micelles Preparation Methods and Applications as Drug Delivery Approach: A Review
Zainab Eassa Jassim, Nawal A. Rajab
pp. 849–857 · DOI: 10.5530/ijpi.20250305 · Published Jul-Sep 2025
Polymeric micelles which are formed by the self-assembly of amphiphilic copolymers, are distinguished among the other forms of nanostructured carriers due to their restricted size distribution, conformation, and surface …
Review
Managing Age-Related Macular Degeneration and Diabetic Macular Edema: A Comprehensive Update for Clinical Pharmacists
Rajesh Hadia, Rahul Trivedi, Sunil Kardani, Sunil Baile, Cyril Sajan, Varunsingh Saggu, Hemrajsingh Rajput
pp. 858–863 · DOI: 10.5530/ijpi.20250310 · Published Jul-Sep 2025
The prevalence of both Age-related Macular Degeneration (AMD) and Diabetic Macular Edema (DME), are notably high, given the significant morbidity they generate and the burden placed on healthcare systems globally. Advanc…
Review
Synthesis and Spectral Analysis of Novel Substituted Benzimidazole Derivatives
Bhagyashri D. Jadhav, Sushil Prabhakar Narkhede
pp. 1006–1011 · DOI: 10.5530/ijpi.20250160 · Published Jul-Sep 2025
Aim The aim of the present study is to synthesize novel series of substituted benzimidazole derivatives and their spectral characterization. Materials and Methods This study presents research on the synthesis of novel se…

Research Article

Article
Exploring Iron Oxide Nanoparticles Innovations and Applications in Cancer Therapy
Megha Roy, Mujibullah Sheikh, Darshan Telange
pp. 793–808 · DOI: 10.5530/ijpi.20250182 · Published Jul-Sep 2025
Iron Oxide Nanoparticles (IONPs) are exciting technology in cancer therapy that represents agents with a unique combination of super paramagnetism, biocompatibility and the capability for surface functionalization toward…

Original Article

Article
Evaluating the Therapeutic Potential of Duartin against Aurora A Protein Kinase in Breast Cancer Cells
Akram Ahmed Aloqbi
pp. 864–872 · DOI: 10.5530/ijpi.20250216 · Published Jul-Sep 2025
Background Cancer, particularly breast cancer, remains a major global health challenge, prompting ongoing research into novel therapeutic targets. This study focuses on Aurora A protein kinase, a serine/threonine kinase …
Article
Design, Synthesis, in silico Molecular Docking, ADMET Analysis and in vitro Antibacterial Activity of Pyranopyrazole Derivatives as Potent Glucosamine-6-Phosphate Synthase Inhibitor
Prerana Badrinath Jadhav, Shital Vilas Wagh, Manjushri Pratap Dabhade
pp. 873–887 · DOI: 10.5530/ijpi.20250157 · Published Jul-Sep 2025
Background The need for new antibacterial medicines arises from the emergence of antibiotic-resistant bacterial strains. Pyranopyrazole derivatives, known for their diverse biological activities, are investigated for the…
Article
In silico Identification of Ascidian-Based Lead Compound with Antibacterial Activity for Staphylococcus aureus Toxin Proteins α-Hemolysin, TSST-1 and PVL
Naveen Kumar Mohan, Muneeswari Kumar, Amudhanila Padmanaban, Farhanaaz, Zakirullah Samad, Abdul Jaffar Ali Hajamohideen
pp. 888–894 · DOI: 10.5530/ijpi.20250177 · Published Jul-Sep 2025
Background Antibiotic-resistant bacteria pose a significant threat to public health, leading to the development of novel therapeutic approaches. Staphylococcus aureus, a common pathogenic microbe, is a major global healt…
Article
Development and Validation of a Gradient RP-HPLC Method for Concurrent Analysis of Mirabegron and Silodosin in Bulk and Pharmaceutical Tablets
Satti Sandeep Reddy, Rajendran Vijayalakshmi, Shaik Sadhik Ansari, Pilli Sandya
pp. 895–902 · DOI: 10.5530/ijpi.20250183 · Published Jul-Sep 2025
Objectives To quickly and easily identify and quantify Mirabegron and Silodosin in both pure and pharmaceutical dosage forms, a gradient Reverse-Phase High Performance Liquid Chromatography (RP-HPLC) technique was descri…
Article
Health Related Quality of Life and its Predictors among Dyslipidemia Patients: A Cross-Sectional Study
Ramesh Bhandari, Madiwalayya Shivkantayya Ganachari
pp. 903–908 · DOI: 10.5530/ijpi.20250187 · Published Jul-Sep 2025
Objectives To evaluate Health-Related Quality of Life (HRQoL) and its determinants among dyslipidemia patients. Materials and Methods A cross-sectional study was conducted among patients with dyslipidemia during 6 months…
Article
Analytical Method Development and Validation for the Simultaneous Quantification of Water-Soluble Vitamins (B Complex) at Single Wavelength by HPLC in Food Supplement
Tejas Vyas, Ujashkumar Shah, Jayvadan Patel, Mrityunjay Tiwari
pp. 909–916 · DOI: 10.5530/ijpi.20250223 · Published Jul-Sep 2025
Background Water-soluble B-complex vitamins are essential for energy metabolism and overall health. Objectives To develop a simple, sensitive, accurate, validated and cost-effective reverse phase liquid chromatographic m…
Article
Standardization of Vaalai Rasa Mezhugu (VRM): A Siddha Formulation
Suresh Ramasamy, Senthamil Selvi Gopalan, Kiruba Annammal Paul Abraham Antonyraj, Siva Annamalai, Abarna Balasubramani, Natarajan Mohan, Sanjana Subramaniam
pp. 917–925 · DOI: 10.5530/ijpi.20250260 · Published Jul-Sep 2025
Background The Siddha system, widely practiced in Tamil Nadu, incorporates plant, mineral and animal components in its medicinal formulations. Vaalai Rasa Mezhugu (VRM) is one such herbo-mineral preparation indicated for…
Article
Pharmacovigilance of Psychotropics among Patients in A Mental Health Institution of Eastern India
Rakesh Meher, Roja Sahu, Santosh Kumar Ranajit, Trupti Rekha Swain, Rabinarayan Rana, Prafulla Kumar Sahu
pp. 926–932 · DOI: 10.5530/ijpi.20250235 · Published Jul-Sep 2025
Introduction Polypharmacy, use of narrow therapeutic index drugs and clinical co-morbidities make the patients administered with psychotropics vulnerable to Adverse Drug Reactions (ADRs) and hence, awareness about it is …
Article
The Impact of Artificial Intelligence (AI) Tools Usage on Buyer Behavior: A Study on Selected Online Pharmacy Apps
Lakshmi Priya Bachina, Anusha Kanagala
pp. 933–941 · DOI: 10.5530/ijpi.20250107 · Published Jul-Sep 2025
AI technologies affect consumers' attitudes, perceived risk and levels of trust, which in turn affects their purchase behavior. The study explores how AI tools, such as voice search, chatbots and recommendation systems, …
Article
Studies on in silico and in vitro Anticancer Activity of Selected Plant Extract Phytocompounds against HeLa and HCT116 Cell Lines
Essakki Subbulakshmi, Sudalaiyanminudi Kumaresan, Pandaram Palanisamy
pp. 942–952 · DOI: 10.5530/ijpi.20250195 · Published Jul-Sep 2025
Background This study explores the phytochemical composition, molecular interactions and cytotoxic potential of ethanolic extracts from four medicinal plants-Solanum virginianum, Hibiscus rosa-sinensis, Piper betle and E…
Article
Formulation and Characterization of Paroxetine Hydrochloride Nasal Gel: An Innovative Approach
Neelima Danga, Rama Devi Korni, Vasavi Laveti, Karakavalasa SVVS Sai Sampath, Jagadeesh Panda, Pavan Kumar Pinagadi
pp. 953–960 · DOI: 10.5530/ijpi.20250172 · Published Jul-Sep 2025
Background Serotonin Reuptake Inhibitors (SSRIs) like paroxetine are selective. It is used to treat several illnesses, such as premenstrual dysphoric disorder, post-traumatic stress disorder, obsessive-compulsive disorde…
Article
Consequences of Nitric Oxide Metabolites in Leprosy: A Systematic Exploration
Anita Dattatray Kadam, Dipali Manoj Khopade, Suresh Bubu Kondaveeti, Hitender Singh Batra
pp. 961–965 · DOI: 10.5530/ijpi.20250124 · Published Jul-Sep 2025
Background Leprosy, an ancient Disease remains a notable health concern in certain nations like India. It is an ongoing disease of infection brought on by Mycobacterium leprae. The production of Nitric Oxide by the actio…
Article
Sun-Protective Potential of Morinda citrifolia: Formulation and Evaluation of Herbal Gel
Lakshmi Thabaj, Rashmi Surve, Shweta Myagadeyavar, Udaykumar Bolmal
pp. 966–971 · DOI: 10.5530/ijpi.20250226 · Published Jul-Sep 2025
Background This study aimed to formulate and evaluate a sunscreen gel containing Morinda citrifolia (Noni) fruit extract, focusing on its Sun Protection Factor (SPF). Sunscreens are primarily used for photo protection an…
Article
Predictability, Severity and Causality Assessment of Adverse Drug Reactions Reported at a Tertiary Care Hospital in Belagavi, North Karnataka: A Prospective Observational Study
Mandati Santhosh Reddy, Pratiksha Nagesh Kini, Madiwalayya Shivkantayya Ganachari
pp. 972–976 · DOI: 10.5530/ijpi.20250180 · Published Jul-Sep 2025
Introduction Adverse Drug Reactions (ADRs) present major challenges in healthcare, contributing significantly to hospital admissions and impacting a large number of inpatients. Monitoring ADRs often relies on electronic …
Article
An RP-HPLC Method for the Concurrent Measurement of Almitrine and Raubasine in Tablet and Bulk Forms: Development and Validation
Rajendran Vijayalakshmi, Shaik Sadhik Ansari, Satti Sandeep Reddy, Pilli Sandya
pp. 977–983 · DOI: 10.5530/ijpi.20250222 · Published Jul-Sep 2025
Background This study work introduces a straightforward, sensitive, specific, and efficient stability-indicating HPLC approach designed for the simultaneous measurement of Almitrine and Raubasine in both pre-formulation …
Article
Precision Packaging and Personalized Medicine: 3D Printing’s Role in Modern Healthcare
Bachunaga Kishore Babu, Daniel Pilli, Podile Venkateswara Rao, Veena Tewari
pp. 984–991 · DOI: 10.5530/ijpi.20250247 · Published Jul-Sep 2025
Background The pharmaceutical industry faces ongoing challenges in mass production, drug personalization, and sustainable packaging. Traditional manufacturing methods often fail to meet the growing demand for tailored th…
Article
Development and Optimization of Cocoa-Based Herbal Face Pack Using Design of Experiments
Rashmitha Rama Devadiga, Sadeeksha, Reeha, Rohan, Ashwini Madhava
pp. 992–997 · DOI: 10.5530/ijpi.20250191 · Published Jul-Sep 2025
Background Skincare products featuring natural ingredients are widely favored for their perceived efficacy and safety. This study aimed to develop and evaluate cocoa fruit-based formulations for skincare, enriched with s…
Article
Optimization and Validation for Simultaneous Estimation of Metformin and Furosemide by Using RP-UFLC
Rakshitha Anjaneya, Rashmi Neligare Gopala
pp. 998–1005 · DOI: 10.5530/ijpi.20250046 · Published Jul-Sep 2025
Background Metformin is a Biguanide derivative used to treat the type-II diabetes, Furosemide is a loop diuretic used in the treatment of hypertension associated with edema. Aim: Our aim is to create an analytical method…
Article
Assessment of the Anti-Tubercular Efficacy of a Hybrid Compound Using in vitro and in silico Methods
Akula Sowjanya, Joshi Meripe, Midde Jeevitha, Udutha Bhanu Prasad, Mallika Shaik, Maipala Uma Mahesh
pp. 1012–1016 · DOI: 10.5530/ijpi.20250132 · Published Jul-Sep 2025
Background Tuberculosis is mostly caused by Mycobacterium tuberculosis; however, it can be caused by a variety of mycobacteria. Tuberculosis predominantly impacts the respiratory system, although it may also affect other…
Article
Anti-Inflammatory and Antimicrobial Activities of Essential Oil of Urochloa distachya (L.)
Smrutiranjan Dash, Rajasekaran Sidhan
pp. 1017–1038 · DOI: 10.5530/ijpi.20250283 · Published Jul-Sep 2025
Background Herbal medicines have been valued for centuries as potent treatments for various conditions, including inflammatory and microbial infections. Urochloa distachya (Signal grass), an annual grass belonging to the…
Article
Simultaneous Determination of Nirmatrelvir and Ritonavir in Bulk and Tablet Dosage Form by RP-HPLC Method
Rohit Gawali, Rahul Keshav Godge, Kavita Dhamak, Arshu Patel
pp. 1039–1044 · DOI: 10.5530/ijpi.20250328 · Published Jul-Sep 2025
Aim A Rational and time-efficient, as well as, selective and gentle approach based on simultaneous estimation to the RP-HPLC verification in compliance with the most recent requirements for nirmatrelvir and ritonavir. Ma…
Article
Insights into Early Identification of Oral Potentially Malignant Disorders and Oral Cancer-A Cross-Sectional KAP Study among Dentists
Mounika Yeladandi, Thirupambaram Nataraja Sundaram Uma Maheswari, Shivani Neelam, Nallan CSK Chaitanya, Harika Vemula, Tejaswi Kala, Mohammed Abidullah
pp. 1045–1051 · DOI: 10.5530/ijpi.20250366 · Published Jul-Sep 2025
Background: Oral cancer, including malignancies of the oral cavity and associated structures, poses a significant global health challenge. Early identification is crucial for improving treatment outcomes and survival rat…
Article
Exploring the Antioxidant Potential of a Polyherbal Combination: A Comprehensive in vitro Study
Athar Aalam, Vaibhav Rastogi, Mayur Porwal
pp. 1052–1061 · DOI: 10.5530/ijpi.20250288 · Published Jul-Sep 2025
Background The objective of this research was to explore the antioxidant potential of the three different medicinal plant extracts namely Curcuma longa, Acacia catechu and Allium cepa along with their combination (polyhe…

Short Communication

Communication
Comparative Analysis of Traditional Medicine Systems During the COVID-19 Pandemic
Shabeer Ahmed Nariyampet, Ashar Waheed Madar Pakir
pp. 1052–1054 · DOI: 10.5530/ijpi.20250215 · Published Jul-Sep 2025
Background The COVID-19 pandemic has created unprecedented challenges for global health systems, driving interest in exploring complementary approaches, including traditional medicine systems. Ayurveda, Siddha, Unani and…