Volume 15, Issue 4

Oct-Dec 2025 · pp. 1–1424 · 39 articles

Volume: 15
Issue: 4
Published: Oct-Dec 2025
Pages: 1–1424
Articles: 39
Sections: 2
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Original Article Review Article

In this issue

Original Article

Article
Validation of an Extractive Spectrophotometric Method for Determining Lauric Acid in Virgin Coconut Oil
Arvind Raghav, Vaibhav Rastogi, Arulsamy Elphine Prabahar
pp. 1–7 · DOI: 10.5530/ijpi.20250308 · Published Oct-Dec 2025
Background An easy, quick, sensitive and precise extractive spectroscopic approach has been devised for the determination of lauric acid in pure form as well as present in virgin coconut oil. The approach is based on the…
Article
Development of Resveratrol-Quercetin Face Serum: A Dual Defence against Aging and Acne
Vandhana Vijayakumar, Thirumalaikumaran Rathinam, Abida Haripriya Rammohan, Dharshini Sagadevan, Udhayakumar Thangavelu
pp. 1168–1174 · DOI: 10.5530/ijpi.20250175 · Published Oct-Dec 2025
Objectives This study centers on the development and assessment of a facial serum fortified with the innate antioxidant’s resveratrol and quercetin, to address skin aging and acne. Materials and Methods The serum was car…
Article
Assessment of Anti-Inflammatory Properties of Methanolic Root Extract of Plumeria alba Linn.: An in vitro and in vivo Approach
Harshitha Nagaraj, Kusu Susan Cyriac, Deepak Kumar Jha
pp. 1175–1183 · DOI: 10.5530/ijpi.20250149 · Published Oct-Dec 2025
Background Inflammation is the body's innate defence mechanism that is initiated in reaction to injury or on exposure to detrimental agents. Plumeria alba Linn, a small laticiferous tree rich in phytochemicals and antiox…
Article
Formulation and Evaluation of Celecoxib and Apixaban Emulgel for Topical Delivery
Amaresh Chandra Sahoo, Sujit Dash, Prabhat Kumar Sahoo, Minaketan Sahoo
pp. 1184–1194 · DOI: 10.5530/ijpi.20250206 · Published Oct-Dec 2025
Background Emulgel is a combination of gel and emulsion. Drugs are first incorporated into an emulsion and then the conventional emulsion is transferred into an emulgel by using a gelling agent. Objectives To formulate a…
Article
In vitro Vitamin D Treatment Enhances Sperm Motility and Capacitation of Fertile and Infertile Men
Ang Wan Yi, Mukhri Hamdan, Giribabu Nelli
pp. 1195–1205 · DOI: 10.5530/ijpi.20250416 · Published Oct-Dec 2025
Background Male infertility is associated with vitamin D deficiency, and much evidence suggests ways to correct this deficiency to restore fertility. Vitamin D supplementation in men significantly improved fertility and …
Article
Association of Dual Antiplatelet Therapy and Hemoglobin Level in Cardiovascular Patients-A Single Centered Comparative Observational Study
Gobu, Emmanuel, Daniel Sundar Singh, Prakashraj Elumalai, Roshan Nawaz Ayas, Solai Ganesh Subburaj
pp. 1206–1213 · DOI: 10.5530/ijpi.20250299 · Published Oct-Dec 2025
Background Cardiovascular diseases are increasingly becoming a major cause of morbidity and mortality around the world. About half of the deaths due to non-communicable diseases are attributed to some form of cardiovascu…
Article
Evaluating the Neuroprotective and Antioxidant Effects of Orgaheal™ Ashwagandha with Valerian Root caplet in Oxidative Stress Models: In vitro study
Rajendran, Sudesh Raj, Tejas, Jayakumar, Sneha, Reethi
pp. 1214–1226 · DOI: 10.5530/ijpi.20250211 · Published Oct-Dec 2025
Background Ashwagandha (Withania somnifera), traditionally valued for enhancing stress resilience, is known for its neuroprotective and antioxidant effects. This study explores the Orgaheal™ Ashwagandha with Valerian Roo…
Article
Identification of Essential Proteins as Promising Therapeutic Targets against Drug Resistant Strain of Staphylococcus aureus: An in silico Approach
Monish Mukul Das, Sayan Chakraborty, Avijit Mondal, Tapas Guha
pp. 1227–1234 · DOI: 10.5530/ijpi.20250261 · Published Oct-Dec 2025
Background Staphylococcus aureus is a gram-positive pathogen which contributes community-associated and nosocomial serious diseases and it has become resistant to various antimicrobials. Owing to rapid advent and continu…
Article
Multi-Dataset Identification and Validation of New Gene Expression Signatures: Insights into Matrix Remodeling Pathways in NSCLC
Rashed Mohammed Alghamdi
pp. 1235–1248 · DOI: 10.5530/ijpi.20250268 · Published Oct-Dec 2025
Background Non-Small Cell Lung Cancer (NSCLC) epitomizes 85% of lung cancer cases with poor survival rates. Understanding molecular mechanisms through gene expression analysis is important for developing real treatments.…
Article
Assessment of Drug Utilization and Adequacy of Analgesics Usage among Postoperative Patients in Orthopedics Department in a Tertiary Care Hospital-A Prospective Observation Study
Belum Jyoshna, Vadlavari Pavan Chandu, Valmiki Uday Sai, Gaddam Vamsidhar Reddy, Bandi Sai Supraja, Caleerappa Ravi Shankar, Akkiraju Sudheer
pp. 1249–1253 · DOI: 10.5530/ijpi.20250300 · Published Oct-Dec 2025
Background According to WHO Drug Utilization research, it is defined as "the marketing, distribution, prescription, and use of drugs in a society, with special emphasis on the resulting medical, social, and economic cons…
Article
Ayurveda's Impact on Anemia among Rural School Children in Belagavi, Karnataka: An Observational Study
Sandeep Subhash Sagare, Srinivas Prasad Buduru, Kavita Sutagatti, Zeba Mulla
pp. 1254–1260 · DOI: 10.5530/ijpi.20250306 · Published Oct-Dec 2025
Background/Purpose Anemia poses a significant public health challenge, particularly in developing nations. Indian government has initiated several programs aimed at reducing the prevalence of anemia, such as providing ir…
Article
Assessment of Association between Natriuretic Peptides (MR-pro-ANP and NT-pro-BNP) and Cardiovascular Risk in Patients with Type II Diabetes: A Prospective Observational Study
Daniel Sundar Singh, Anand Pithadia, Lavanya
pp. 1268–1273 · DOI: 10.5530/ijpi.20250317 · Published Oct-Dec 2025
Background Cardiovascular disease is the major cause of morbidity and mortality in individuals with T2DM. Although many promising cardiac markers have been identified, a single Natriuretic peptide biomarker is unlikely t…
Article
Impact of Educational Interventions on Materiovigilance Awareness among Pharmacy Students: A Cross-Sectional Study
Akshata Gore, Arfa Anwar Sayed, Shamita Shyam Sail, Ramish Khan, Agadi Hiremath Viswanatha Swamy, Sanatkumar Bharmu Nyamagoud
pp. 1281–1287 · DOI: 10.5530/ijpi.20250325 · Published Oct-Dec 2025
Background Medical devices are used vitally in the healthcare system. Since India is a developing country, it didn’t have a valid outline to screen and notice the adverse events occurred using medical devices. Hence, mat…
Article
Effectiveness of Educational Interventions in Enhancing Pharmacy Students KAP of Materiovigilance
Arfa Anwar Sayed, Akshata Gore, Shamita Shyam Sail, Ramish Khan, Agadi Hiremath Viswanatha Swamy, Sanatkumar Bharmu Nyamagoud
pp. 1288–1297 · DOI: 10.5530/ijpi.20250326 · Published Oct-Dec 2025
Background The Materiovigilance Programme of India (MvPI) was launched on 6th July 2015 by the (DCGI) at the Indian Pharmacopoeia Commission, to ensure the safety and effectiveness of medical devices. With the increasing…
Article
Impact of Medication Adherence on Health-Related Quality of Life in Women with Polycystic Ovary Syndrome: A Cross-Sectional Study
Om Prakash Bhallaram Choudary, Aasiya Nadaf, Pratiksha Bajarang Bhandare, Agadi Hiremath Viswanatha Swamy, Sanatkumar Bharamu Nyamagoud, Abhishek B J, Pratik Naveenkumar Magadum, Shivamantesh Ashok Kittur, Chandrashekar Mallikarjun Patil, Vinod Ashok Koujalagi
pp. 1298–1303 · DOI: 10.5530/ijpi.20250333 · Published Oct-Dec 2025
Background Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder in young women, marked by hormonal imbalances, insulin resistance, and elevated androgens. Each of these factors causes medical conditions such a…
Article
Assessment of Probable Drug-Drug Interactions in IPD Geriatric Patients at Tertiary Care Teaching Hospital
Akshata Manjunath Purantar, Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Viswanatha Swamy, Bibi Khuteja Jangliwale, Kaushal Kumar, Rakshita T P
pp. 1304–1310 · DOI: 10.5530/ijpi.20250334 · Published Oct-Dec 2025
Background Older adults are at a higher risk of experiencing drug-drug interactions due to their tendency to use several medications simultaneously, which may include prescription medications, over-the-counter products a…
Article
Investigating the Potential of Lepidium sativum Seed Mucilage as Binder in Tablet Formulation
Yogita Shinde, Gitanjali Deokar
pp. 1311–1319 · DOI: 10.5530/ijpi.20250345 · Published Oct-Dec 2025
Introduction The demand for natural excipients in pharmaceuticals has driven interest in plant-based materials. Lepidium sativum seed mucilage, a polysaccharide-rich and biocompatible compound, shows promise as a tablet …
Article
Method Development and Validation of Olmesartan Medoxomil by Using RP-HPLC
Anchal Kushwaha, Kandasamy Nagarajan, Richa Goel, Garima Kapoor, Snigdha Bhardwaj, Pankaj Bhatt
pp. 1320–1331 · DOI: 10.5530/ijpi.20251665 · Published Oct-Dec 2025
Background Olmesartan (OLM) is a drug used to treat hypertension, or elevated blood pressure. Controlling high blood pressure lowers the chance of further strokes, renal problems and heart attacks. Materials and Methods …
Article
Correlation of Pradhana Deha Prakriti with Menstrual Signs and Symptoms During Menses in Mid-Age Healthy Women of Belgaum District: An Observational Study
Kadambari Solankure, Vinod Gurav, Usharani Sanu, Nayana Bhagat, Eksheka Mall
pp. 1332–1339 · DOI: 10.5530/ijpi.20250294 · Published Oct-Dec 2025
Background Prakriti is a unique concept, which exceptionally finds its presence in Ayurveda. It is the unique psychosomatic constitution of an individual, constituted on the basis of the innate qualities of the matruja b…
Article
Exploring the Wound Healing Activity of Turmeric Oil Based Emulgel through Topical Drug Delivery
Vibha, Shiv Bahadur, Meenakshi Bajpai
pp. 1340–1347 · DOI: 10.5530/ijpi.20250272 · Published Oct-Dec 2025
Introduction Wounds may be known as any damage or distortion to the normal structural and functional of skin, if left untreated it can be more dangerous, reaching in subcutaneous tissue and serious harm to other structur…
Article
In situ Forming Dental Cement Loaded with Metronidazole and Doxycycline to Treat Periodontitis
Anuj Kumar, Anurag Verma
pp. 1348–1359 · DOI: 10.5530/ijpi.20250312 · Published Oct-Dec 2025
Background In situ forming dental cements offer a novel approach to treating periodontitis by enabling localized delivery of therapeutic agents directly to the periodontal cavity. Hydroxyapatite-based materials hold prom…
Article
High-Efficiency Drug Characterization through Microchannel-Integrated Microfluidic Systems
Bolleddu Ravi, Thangallapalli Srinivas, Kuntla Raj Kumar, Mannepalli Sudheera
pp. 1360–1364 · DOI: 10.5530/ijpi.20250007 · Published Oct-Dec 2025
Aim/Background Micro-channels, characterized by their minuscule size ranging from 10 µm to 200 µm, find diverse applications across various fields such as biomedical, electronics, and chemical reactors, etc. Here, it was…
Article
Garcinia mangostana L. Fruit Peel-A Novel Source of Melatonin
Swarna Lekha Suresh Gandhi, Anitha Rajasekaran, Harika Manniam Saravanabava, Munusami Angusami
pp. 1365–1369 · DOI: 10.5530/ijpi.20250008 · Published Oct-Dec 2025
Background Melatonin (N-acetyl -5- methoxy-tryptamine) is a mammalian neuro hormone, with numerous biological functions found in animals, plants, microorganisms and one of the extensively used dietary supplements. Phytom…
Article
Neuroprotective Effect of IQUP-B Against Scopolamine-Induced Cognitive Impairment in Wistar Rats
Kezia Mangalampalli, Aravinda Sai Kolusu, Hrushik Kowtinya Ramineni, Harshitha Mudigonda, Surya Devarakonda, Pavan Kumar Samudrala
pp. 1370–1379 · DOI: 10.5530/ijpi.20250009 · Published Oct-Dec 2025
Background Cholinergic neurons in the brain and hippocampus appear to be most affected in the early stages of Alzheimer's Disease (AD). Cognitive impairment has been induced in rodents for many years with the muscarinic …
Article
Antibacterial, Antioxidant and Anti-Inflammatory Effect with GCMS Profile of Edible Mushroom Fermented by LAB
Jamith Basha Abdul Wahid, Mohameed Aljuwayd, Muhannad Alruwaili, Wesam Nofal
pp. 1380–1387 · DOI: 10.5530/ijpi.20250304 · Published Oct-Dec 2025
Background Nutritional modifications arise from an enhanced understanding of the importance of food and its impact on human well-being. Objectives This study investigates the fermentation-based preservation of edible mus…
Article
Synthesis, Spectroscopic, Biological Screening of Mn (II) and Cu (II) Complexes with Cysteine
Vinay Kumar Srivastava, Khushboo Rani
pp. 1388–1395 · DOI: 10.5530/ijpi.20250102 · Published Oct-Dec 2025
Objectives Cysteine is a promising ligand for synthesizing complexes with Mn (II) and Cu (II) ions. The main objectives of the study were to synthesize, characterize and examine the Biochemical behavior of metal complexe…
Article
RP-HPLC Method Development and Validation for Simultaneous Quantification of Ascorbic and Gallic Acids in Natural Extract-Based Granules
Tejas Vyas, Ujashkumar Shah, Jayvadan Patel, Mrityunjay Tiwari
pp. 1396–1402 · DOI: 10.5530/ijpi.20250407 · Published Oct-Dec 2025
Background Ascorbic acid and gallic acid are known for immune-boosting and antioxidant properties. Objectives To develop a straightforward, sensitive, validated, and economical reverse phase liquid chromatographic techni…
Article
Investigation of Neuronal and Adrenocortical Changes in Metyrapone- An 11 β-hydroxylase Inhibitor Induced Adrenal Insufficiency in Wistar Rats
Vakkalagadda Siva Ganesh, Bharathi Doddla Raghunathanaidu
pp. 1403–1408 · DOI: 10.5530/ijpi.20250545 · Published Oct-Dec 2025
Background 11β-hydroxylase plays a key role in adrenal steroid hormone production, making it crucial in the development of adrenal insufficiency. Recently, there has been increasing interest in targeting this enzyme to i…
Article
In silico and ADMET/Pharmacokinetics Prediction Studies of Some Novel Pyrido-Pyrimidine Derivatives as Anticancer
Pratibha Yadav, Kamal Shah
pp. 1409–1416 · DOI: 10.5530/ijpi.20250577 · Published Oct-Dec 2025
Objectives To investigate the mechanism of pyridopyrimidines derivatives against monopolar spindle1 anticancer target and also predicts the pharmacokinetics parameters involved absorption, distribution, metabolism, elimi…
Article
A Prospective Observational Study on Assessment of Etiology, Complications, and Stages of Renal Diseases in the Khammam District of Telangana
Patibandla Sai Sandhya, Soma Mani Santhosh Nikhil, Phakkir Vineela Reddy, Rekala Niharika, Maram Chinnaeswaraiah
pp. 1417–1424 · DOI: 10.5530/ijpi.20250441 · Published Oct-Dec 2025
Background Renal pathologies, encompassing Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI), represent considerable public health challenges, contributing to heightened morbidity and mortality rates on a global…

Review Article

Review
A Short Review on Microglia in Neurodegenerative Disorders: An Overview of Natural Products in the Treatment of Neurodegenerative Disease by Targeting Arginase 1
Mohomed Faizal Umair Ahamed, Gothai Sivapragasam, Nanthini Sridewi Appan
pp. 1065–1072 · DOI: 10.5530/ijpi.20250125 · Published Oct-Dec 2025
This review offers an overview of the crucial role microglia play in neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's diseases. It also delves into the therapeutic potential of natural produc…
Review
Developments in Small Molecule Therapeutics Targeted Drug Delivery Systems for the Treatment of Breast Cancer: Present Approaches
Abdulhadi M Abdulwahed
pp. 1073–1085 · DOI: 10.5530/ijpi.20250384 · Published Oct-Dec 2025
This review aims to discuss the progress made in targeted drug delivery of small molecules in breast cancer, as well as the methods that can be used to increase the accuracy of the treatment and reduce the overall toxici…
Review
Mechanistic Modelling of Chromatographic Processes: Its Trends, Development, Challenges and Applications
Gopinath Govindarajan, Ranganadhareddy Aluru
pp. 1086–1095 · DOI: 10.5530/ijpi.20250277 · Published Oct-Dec 2025
In biopharmaceutical manufacturing chromatography technique has been the backbone of purification process. As bioprocessing has advanced, a growing trend has emerged toward gaining a thorough understanding of the fundame…
Review
Advances in Collagen Biomaterials for Dental Applications: A Review from Biofabrication to Clinical Practice
Rajendran Akash, Sathiyamoorthy Rajesh, Bhuvaragavan Devishree, Karthikeyan Aravind, Selvaraj Deepa, Kesavan Sathesh Kumar
pp. 1096–1107 · DOI: 10.5530/ijpi.20250319 · Published Oct-Dec 2025
This review article provides a comprehensive examination of collagen-loaded dental applications, focusing on collagen dental plugs used for socket preservation and tissue regeneration following tooth extraction. It explo…
Review
Quality by Design: A Strategic Approach to Pharmaceutical Development
Mahavir M. Sharma, Harshkumar Brahmbhatt, Priyanka Shah, Ujjval P. Vaghela
pp. 1122–1129 · DOI: 10.5530/ijpi.20250488 · Published Oct-Dec 2025
This review delineates the primary objectives of Quality by Design (QbD) and provides an in-depth exposition of its foundational concepts. The core components of QbD include: (1) the establishment of a comprehensive cont…
Review
Decentralized Clinical Trials: Bridging Innovation and Regulation
Venkateswara Raju Kalidindi, Gutturu Dheeraj Balaji, Uda Mahalakshmi, Sirilla Dinesh Babu, Badugu Priyanka, Tekumudi Vasantha Naga Lakshmi, Lakshmi Prasanthi Nori
pp. 1130–1143 · DOI: 10.5530/ijpi.20250005 · Published Oct-Dec 2025
Decentralized Clinical Trials (DCT) utilize digital health technologies, remote monitoring, and telehealth, eliminating the need for traditional in-person visits to clinical sites. This model provides significant benefit…
Review
Tracking Risks, Saving Lives: How India and the U.S. Protect Patients through Materiovigilance
Lakshmi Prasanthi Nori, Ketha Bhavani, Yamini Satya Sri, Gangomolu Pujitha, Kiran Manda, Sudarshan Rao Nagineni, Kalidindi Venkateswara Raju
pp. 1144–1152 · DOI: 10.5530/ijpi.20250006 · Published Oct-Dec 2025
Materiovigilance refers to the system of safety monitoring and performance of medical devices after being placed on the market and involves collecting, analyzing, and responding to reports of malfunctions, adverse events…
Review
Medical Education in the Era of Artificial Intelligence
Jiafeng Li, Tiefeng Jin, Meihua Zhang
pp. 1153–1159 · DOI: 10.5530/ijpi.20250329 · Published Oct-Dec 2025
The "Four New" initiatives have emerged as a pivotal framework for advancing higher education in China. Among these, the promotion of New Medical Sciences not only meets the evolving demands of the contemporary era but a…
Review
Unlocking the Potency of Endophytic Fungi: Connecting Discovery Endophytic Fungi for Bioactive Compound
Sagar Mysore Shivakumar, Rashmi Nelligare Gopalakrishna
pp. 1160–1167 · DOI: 10.5530/ijpi.20250255 · Published Oct-Dec 2025
Endophytic fungi have engrossed the most attention owing to their prospect of being a source of many bioactive compounds. These fungi are regarded as effective producers of valuable metabolites, such as antibacterial, an…