Volume 16, Issue 1

Jan-Mar 2026 · pp. 1–370 · 39 articles

Volume: 16
Issue: 1
Published: Jan-Mar 2026
Pages: 1–370
Articles: 39
Sections: 3
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article Research Article

In this issue

Review Article

Review
Anti-Parkinson Drug Levodopa: It's Novel Delivery Systems, Preclinical and Clinical Studies: A Review
Oyitabu Ifunanya Mercy, Vemula Kusum Devi, Vijaya Gopalachar Joshi, Gagana Dhanalakshma Nayaka, Urmila Gurupadhaya Hiremath, Malviya Nidhi, Priyanka Nandibasappa, Rama Bukka, Rama Radhakrishna Nargund, Shravan Laxmivenkatesh Nargund, Shachindra Laxmivenkatesh Nargund
pp. 1–11 · DOI: 10.5530/ijpi.20260415 · Published Jan-Mar 2026
Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons and the presence of Lewy body pathology. Its prevalence increases with age, affecting approxi…
Review
Shifting Regulatory Frameworks for Nanomedicine in the Evolution of Personalized Medicine
Lakshmi Prasanthi Nori, Chintakrindi Parvesh, Akshaya Ratna Kireeti, Jyothika Chittala, Lavanya Chintalapati, Kudeti Himaja Kasturi, Kalidindi Venkateswara Raju
pp. 12–22 · DOI: 10.5530/ijpi.20260001 · Published Jan-Mar 2026
The integration of nanomedicine with personalized medicine represents a transformative paradigm in healthcare, significantly enhancing the diagnosis, treatment, and prevention of diseases. However, the regulatory framewo…
Review
A Global Perspective on Navigating the Regulatory Landscape of Adaptive AI in Healthcare: Balancing Innovation and Patient Safety
Sandeep Talari, Vivek Reddy Murthannagari, Gundavarapu Kanaka Phani Kumar, Gowthamarajan Kuppusamy, Srikanth Jupudi
pp. 23–29 · DOI: 10.5530/ijpi.20260314 · Published Jan-Mar 2026
In healthcare, adaptive AI and machine learning offer continuous performance improvement through patient data updates, but traditional regulation methods are slow and cumbersome. The USFDA and EMEA propose a paradigm shi…
Review
Impact of Artificial Intelligence Assisted Drug Therapy Optimization on Drug Related Problems Amongst Older Adult Patients: A Systematic Review
Jehath Syed, Christy Thomas, Bavneet Kaur, Prathibha Pereira, Tejaswini Chittanahalli Jayaram, Krishna Undela, Ramesh Madhan, Pramod Kumar Teggina Math, Vikarm Patil, Shilpa Avarebeel, Kshama Ramesh, Sri Harsha Chalasani
pp. 30–42 · DOI: 10.5530/ijpi.20260506 · Published Jan-Mar 2026
Drug-Related Problems (DRPs) are common among hospitalized older adult patients and can lead longer hospital stays, worsening clinical conditions, increased healthcare costs, and even death. Artificial Intelligence (AI)-…
Review
The Empowerment of Drugs Inspectors Under the Drugs and Cosmetics Act, 1940-A Review of Implementation of Power of Arrest Conferred by Hon’ble Supreme Court of India
Vishal Sachan, Tanveer Naved, Ajay Sachan, Yamini Kohli
pp. 43–50 · DOI: 10.5530/ijpi.20260343 · Published Jan-Mar 2026
Background The criminal offences under the Drugs and Cosmetics Act, 1940 (DCA) directly affect the life of people in India. As per statute, it is obligatory for Drugs Inspector to conduct investigation and execute furthe…
Review
Digital Surveillance and Artificial Intelligence in Detection of AEFI: A New Frontier in Vaccine Safety Monitoring
Soiba Siddiqui, Madhan Ramesh, Prashanth Sathya Narayana
pp. 51–57 · DOI: 10.5530/ijpi.20260414 · Published Jan-Mar 2026
The integration of digital surveillance and Artificial Intelligence (AI) technology constitutes a significant shift in Adverse Event Following Immunization (AEFI) monitoring. This review explores the artificial intellige…
Review
A Systematic Review of Vaccination, Prevention, and Public Health Measures for the Human Papillomavirus Epidemic Among Patients in India
Satya Obbalareddy, Anubhav Dubey, Mamta Kumari, Chandan Mukherjee, Sanyogita Shahi, Sayantan Dutta
pp. 58–65 · DOI: 10.5530/ijpi.20260462 · Published Jan-Mar 2026
Nearly 70% of the population will be infected with Human Papillomavirus (HPV) at some point in their lives; in India, 27,526 women are diagnosed with the virus each year, and 79,906 lose their lives to it. Research has l…
Review
A Comprehensive Review of Biopolymers Used in Sustainable Development of Nanoformulations
Ruchi Tiwari, Priyanka Shukla, Gaurav Tiwari, Mahesh Kumar Posa, Mallikarjun Mugli, Anurag Mishra
pp. 66–76 · DOI: 10.5530/ijpi.20260447 · Published Jan-Mar 2026
A biopolymer is a naturally derived polymer, obtained from living organisms like plants, animals and various microorganism. The biopolymer is made up of various monomer units which are linked together with each other thr…
Review
An Overview on Microneedle Technology: Superior Pharmaceutical Transdermal Delivery Forms
Paramita Ganguly, Puja Saha, Sourav Khawas, Sandip Chatterjee, Arvind Kumar Patel, Prangyan Paramita Pati
pp. 77–88 · DOI: 10.5530/ijpi.20260499 · Published Jan-Mar 2026
Microneedles, first introduced in 1976, address these limitations by creating tiny, non-invasive channels that enhance drug penetration through the skin. Transdermal Drug Delivery (TDD) is a less intrusive approach that …
Review
A Review on Impact of Syzygium aromaticum, Nigella sativa, and Mesua ferrea on Alzheimer’s Disease
Mamatha Gavisiddaiah, Kenganora Mruthunjaya, Santhepete Nanjundaiah Manjula
pp. 89–97 · DOI: 10.5530/ijpi.20260338 · Published Jan-Mar 2026
Alzheimer's Disease (AD), characterised by cognitive impairment and memory loss, is primarily caused by the deterioration of the central nervous system, which is a vital component of the human body. Amyloid-beta plaque b…
Review
Eco-Friendly Nanoparticles in Drug Delivery: Insights from Plant-Based Systems
Kirtimaya Mishra, Asra Jabeen, Sarojini Nayak, Ritupriya Mohanty, Debasis Patra, Diptimayee Jena
pp. 98–104 · DOI: 10.5530/ijpi.20260472 · Published Jan-Mar 2026
The sustainable substitute for conventional nanomaterials, Plant-Derived Nanoparticles (PDNPs), employ green synthesis techniques to reduce their negative effects on the environment while increasing their medicinal effec…
Review
Exploring Cubosomes as an Emerging Approach of Novel Drug Delivery System: A Review
N Amitha, DS Sandeep, P Rajanikant, MP Gowrav, S Kathirvel, HK Pradeep, MR Jeyaprakash
pp. 105–110 · DOI: 10.5530/ijpi.20260359 · Published Jan-Mar 2026
Cubosomes are self-assembled nanostructures that exhibit a bicontinuous cubic phase. These nanoparticles can incorporate many drugs, including amphiphilic, hydrophilic, and lipophilic substances. The structure of cubosom…
Review
Oral Transmucosal Delivery Systems: Exploring Innovative Dosage Forms, Current Industrial Applications and Regulatory View
Chinna Reddy Palem, Ravinder Rendla, Vamshi Krishna Lekkala, Neha Andhi, Nishant Kumar Nagamalli, Deepthi Battula, Sridhar Gumudevelli
pp. 111–122 · DOI: 10.5530/ijpi.20260433 · Published Jan-Mar 2026
Oral transmucosal drug delivery systems represent an innovative approach for the administration of therapeutic agents through the mucosal membranes, such as sublingual and buccal membranes in the mouth, offering advantag…

Original Article

Article
Antidepressant Potential of Albizzia lebbeck SLNs
S K Kavitha, Mohammad Ali
pp. 123–132 · DOI: 10.5530/ijpi.20260573 · Published Jan-Mar 2026
Background To assess in vivo antidepressant of Ethanolic extract of Albizzia lebbeck (L.) own their family Fabaceae the plant's primary constituents Triterpenes, glycosides, saponins, flavonoids, and indole alkaloids are…
Article
In silico and in vitro evaluation of phytoconstituents for their NADPH Oxidase 5 (NOX5) inhibitory activity
Payal Shah, Gaurang Shah
pp. 133–142 · DOI: 10.5530/ijpi.20260444 · Published 2026
Background Reactive oxygen species (ROS), produced by different enzymes, play a role in oxidative stress, which is linked to the development of many diseases. The NADPH oxidase (NOX) enzyme family serves as a primary sou…
Article
Impact of an Educational Intervention on Knowledge, Attitude, and Practice among Women Diabetic Patients : A Prospective Randomized Controlled Study
Anushree Shrikant Deshpande, Madiwalayya Shivakantayya Ganachari
pp. 143–154 · DOI: 10.5530/ijpi.20260494 · Published Jan-Mar 2026
Background Diabetes Mellitus (DM) is a serious worldwide health challenge, currently affecting over 425 million people globally. India bears a significant burden, with approximately 74 million diagnosed cases as of 2021.…
Article
Synergistic Anti-Stress Effect of Selected Medicinal Plants in Mice
Vinod Ashokdas Bairagi, Deepak Balasaheb Somavanshi, Yogesh Suresh Ahire, Jayashri Sanjay Nikam, Swapnil Bandu Jadhav, Mohammed Saad Abdul Hameed, Chandrashekhar Dinkar Patil, Amol Mohan Shirode, Mohammad Ikrama
pp. 155–166 · DOI: 10.5530/ijpi.20260003 · Published Jan-Mar 2026
Background The discovery of efficacious anti-stress therapies is imperative, as chronic stress plays a substantial role in the development of numerous physical and mental health issues. Materials and Methods The present …
Article
A Novel Eco-Compatible Green UV-Spectroscopic Analytical Method Development and Validation for Apremilast Estimation in Bulk, Marketed Formulation and in Nanovesicles
Kishori Prasanna Sutar, Sunil Satyappa Jalalpure
pp. 167–173 · DOI: 10.5530/ijpi.20260513 · Published Jan-Mar 2026
Background The proposed study focuses on developing and validating a sensitive and simple UV-spectroscopic technique for apremilast quantification in bulk drug, commercial tablet, cubosomes and transferosomes. Materials …
Article
3D-QSAR and Molecular Docking Studies on Benzimidazole Derivatives: Validation of Experimental Inhibitory Potencies Towards COX-1 (PDB: 2OYE) and COX-2 (PDB: 4COX)
Pruthviraj Vijay Kute, Rohit Jaysing Bhor, Mahesh Hari Kolhe, Harshada Shubhash Bhosale, Pornima Ramdas Tambe, Mayuri Rajesh Bhoknal, Pratibha Shankar Jadhav, Swapnali Baban Avhad, Mayuri Girish Dharam, Ajay Sanjay Mule
pp. 174–183 · DOI: 10.5530/ijpi.20260361 · Published Jan-Mar 2026
Background The computational study of benzimidazole derivatives is the main topic of this article. All compounds' cytotoxicity against inflammation was assessed, and the outcomes showed that several of them had strong in…
Article
Identification of Bioactive Compounds by GC-MS Analysis and In vitro Antioxidant Activities of Debregeasia longifolia (Burm.f.) Wedd.: Medicinal Plant
Suresh Kumar Thirumoorthi, Rama Prabha Mani
pp. 184–192 · DOI: 10.5530/ijpi.20260303 · Published Jan-Mar 2026
Objectives The study was aimed to investigate the presences of bioactive components by Debregeasia longifolia through Gas Chromatography-Mass Spectrometry (GC-MS) analysis and evaluate its in vitro free radical scavengin…
Article
A Randomized, Open Label Study to Assess the Impact of Electronic Information Technology in Treatment of Obstructive Airway Disease on Inhaler Therapy in Tertiary Care Hospital
Rajesh Hadia, Nishi Sheth, Deep Patel, Vidhi Saparia, Ronak Shah, Hemrajsingh Rajput, Arti Shah
pp. 193–200 · DOI: 10.5530/ijpi.20260309 · Published Jan-Mar 2026
Background Over 300 million people are affected worldwide with asthma. Asthma, COPD and TOPD are respiratory disorders of chronic inflammatory illness causing bronchial hyperactivity. eHealth applications are widely used…
Article
New RP-HPLC Method Development and Validation, Incorporating Quality by Design (QbD) with Force Degradation Study for Alectinib Estimation-A Green Approach
Jyoti Tangde, Sanjay Sawant
pp. 201–209 · DOI: 10.5530/ijpi.20260313 · Published Jan-Mar 2026
Objectives The present research work focuses on development and validation of Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) for the estimation of alectinib with force degradation study based on Quality b…
Article
Exploring the Bioactivity of Zinc Oxide Nanoparticles Synthesized Using Kigelia africana Fruit Extract
Dharshini Jaisankar Hindumathi, Jubilee Ramasamy, Deepika Jothibasu, Niranjani Ravikumar, Binoy Varghese Cheriyan, Kaniga Pandi
pp. 210–224 · DOI: 10.5530/ijpi.20260318 · Published Jan-Mar 2026
Background Nanoparticles are nanoscale materials that are well known for their distinct physical and chemical characteristics. Owing to their tiny size and special characteristics, nanoparticles such as zinc oxide nanopa…
Article
Polypharmacy and Probable Drug Interactions in Cardiovascular Patients at a Tertiary Care Hospital
Srajana Shetty, Rakshita Paladi, Sachin Basavaraj, Sanatkumar Bharamu Nyamagoud, Agadi Hiremath Vishwanath Swamy, Latha Maregouda Goudar, Sai Sowmya Bhupathiraju, Shruti Achyut Khandke, Arpita Ravindra Walvekar, Shreya Salgare, Nida Khanum Sirdesai
pp. 225–231 · DOI: 10.5530/ijpi.20260322 · Published Jan-Mar 2026
Background Cardiovascular Disease (CVD) is a general term for conditions affecting the heart or blood vessels. Globally, CVDs are the primary cause of morbidity and mortality. Frequently, treating CVDs requires intricate…
Article
A Correlation of Molecular Docking and ADME Studies on 5,5-diphenylimidazolidine-2,4-dione: Inhibitors of Human Voltage-Gated Sodium Channel (Nav1.2)-2KAV
Pooja Anil Nikam, Shabnam Babu Shaikh, Girish Ravindra Kokate, Vanita Baban Katore, Saiprasad Vasant Wani, Sabafarin Hasin Shaikh, Rohit Jaysing Bhor
pp. 232–240 · DOI: 10.5530/ijpi.20260371 · Published Jan-Mar 2026
Background The purpose of this work is to use Lipinski's rule to perform molecular docking and drug-likeness analysis of the proposed 5,5-diphenylimidazolidine-2,4-dione. One description claims that the most common chron…
Article
Utilization of NCCMERP Index to Assess and Categorize Medication Discrepancies among Pediatric Patients: A Hospital Based Epileptic Cohort Study
Vivek Nilkanth Patil, Shashikala Chanmallappa Wali, Manjula Gudhoor, Pratiksha N Kini, Madiwalayya Shivakantayya Ganachari, Vishwa Rajakumar Byakod
pp. 241–251 · DOI: 10.5530/ijpi.20260387 · Published Jan-Mar 2026
Background Recurrent seizures characterize epilepsy, affecting 50 million globally, with 12 million in India. Prevalence rates in North India are 6.99 per 1,000 in rural areas and 5.48 in urban areas. Medication errors p…
Article
A Comparative Study of SDS-PAGE, SEC-UV, and SEC-MALS in Assessing Monoclonal Antibody Aggregation
Ajay Pakalapati, Ranganadha Reddy Aluru, Prateeksha Gupta, Charita Yejju
pp. 252–260 · DOI: 10.5530/ijpi.20260404 · Published Jan-Mar 2026
Objectives Monoclonal antibodies are prone to aggregate formation at elevated temperatures due to the disruption of their native conformation resulting in protein denaturation, disulphide linkage disruptions and eventual…
Article
Bio-Analytical Method Development and Validation of Duloxetine in Rat Plasma and Its Application to a Pharmacokinetic Study by Chiral Chromatographic Technique
Nandula Lavanya, Rashmi Nelligare Gopala krishna
pp. 261–271 · DOI: 10.5530/ijpi.20260431 · Published Jan-Mar 2026
Background Duloxetine, a Serotonin-Norepinephrine Reuptake Inhibitor (SNRI), is commonly prescribed for major depressive disorder. Being a chiral compound, it exists as (R)- and (S)-enantiomers, which may exhibit distinc…
Article
From Ghrita to Microemulsion: Innovative Delivery of Medhya Rasayana for Neuroprotection
Sharada Laxman Deore, Ram Chhatrapati Vighne, Bhushan Arun Baviskar
pp. 272–282 · DOI: 10.5530/ijpi.20260458 · Published Jan-Mar 2026
Background The aim of the current investigation is to develop a microemulsion of bioactive enriched fractions of Indian traditional medicinal plants Bacopa monnieri and Centella asiatica to enhance neuroprotective effica…
Article
Application of the WHOQOL-BREF Scale for Evaluating Quality of Life Among Chronic Kidney Disease Patients: A Cross-Sectional Study
Harshavardhan Patil, Geetanjali Salimath, Mallikarjun Karishetti, Ifraa Wariman
pp. 290–296 · DOI: 10.5530/ijpi.20260413 · Published Jan-Mar 2026
Background Chronic Kidney Disease (CKD) significantly impacts QOL through physical, Psychological, and social challenges. This study explores the use of WHOQOL-BREF to assess QOL in dialysis and non-dialysis patients acr…
Article
Effects of Limonin-Induced Hepatotoxicity and Anxiety in Adult Zebrafish
Sharmishta Reddipalli, Madhan Kumar Srinivasan, Lalitha Vaidyanathan
pp. 302–308 · DOI: 10.5530/ijpi.20260475 · Published Jan-Mar 2026
Background The study explores the impact of limonin-induced hepatotoxicity and anxiety in adult zebrafish. Limonin is a chemical compound found in Citrus fruits and seeds, known for its biological properties. Materials a…
Article
Occupational Prevalence of GERD in the Hospitality Sector: A Cross-Sectional Study from Belagavi District, Karnataka
Padmaveer Puthiyidam Sreenikakumar, Sandeep Subash Sagare, Swasthik, Vidya Parasappa Gani
pp. 309–315 · DOI: 10.5530/ijpi.20260425 · Published Jan-Mar 2026
Background Gastroesophageal Reflux Disease (GERD) is a prevalent gastrointestinal disorder that significantly impacts quality of life. Occupational factors such as irregular work schedules, stress, and dietary habits con…
Article
Formulation and Evaluation of Escitalopram Oxalate Oral Films by 32 Factorial Design
Gangireddy Ramana Reddy, Kunderu Ravi Shankar, Shaik Aminabee, Ravulapati Anusha, Komanduri Venkata Nagaraja, Borra Haindavi, Shaik Ramitunnisa, Rayavarapu Sanjay Babu, Pothuri Srinivasa Eswar, Koppula Jyothi
pp. 324–329 · DOI: 10.5530/ijpi.20260478 · Published Jan-Mar 2026
Background The aim of this work was to develop a mouth dissolving film containing Escitalopram oxalate, utilizing basic ingredients such as polymers, plasticizers, sweeteners, saliva-stimulating agents, and flavors, to a…
Article
Assessment of Sleep Quality Among Menopausal Women and its Relationship with Menopausal Symptoms
M J S Twinkle, K Anjali Anand, Nisha Rajesh, Jeslin Maria George, Bipin Shaji, Krishnapriya Radhakrishnan, Shraddha Shetty, Juno Jerold Joel
pp. 330–335 · DOI: 10.5530/ijpi.20260487 · Published Jan-Mar 2026
Background Menopause is the permanent cessation of menstruation, marked by fluctuating estrogen, irregular periods, sleep disturbances, and various physiological and psychological difficulties. The current study was carr…
Article
Impact of a Structured Intervention on Health-Related Quality of Life in Women with Type 2 Diabetes Mellitus: A Randomized Controlled Trial Using the MDQoL-17
Anushree Shrikant Deshpande, Madiwalayya Shivakantayya Ganachari
pp. 336–348 · DOI: 10.5530/ijpi.20260495 · Published Jan-Mar 2026
Background Diabetes Mellitus (DM) is a long-term health condition that can greatly impact Health-Related Quality of Life (HRQOL), especially in women, who often encounter specific difficulties in managing the disease. Ob…
Article
Influence of Natural Polymers on Zolmitriptan Oral Fast Dissolving Film Formulations: A New Approach to Migraine Treatment
Balakrishna Talamanchi, Venkateswara Rao Javvaji, Lakshman Kumar Dogiparthi, Jayanth Babu Sajja, Sai Sruthi Nimmagadda, Vijaya Preethi Parasa, Pavan Ramakrishna Tadikonda, Sabreen Shaik, Fahamida Shaik, Raheema Shaik
pp. 349–356 · DOI: 10.5530/ijpi.20260544 · Published Jan-Mar 2026
Introduction The main purpose of zolmitriptan fast-dissolving films aims to deliver zolmitriptan effectively alongside quick action for migraine therapy through a user-friendly dosage method. Fast dissolving films dissol…

Research Article

Article
Comparative Analysis of Functional Capacity Improvements Through 6MWD Testing Across Different Respiratory Conditions: Implications for Targeted Pulmonary Rehabilitation
Sneha Chacko, Gaurang Shah
pp. 283–289 · DOI: 10.5530/ijpi.20260451 · Published Jan-Mar 2026
Background The 6-Min Walk Distance (6MWD) test is widely used to assess functional capacity in respiratory patients, but response patterns across different respiratory conditions remain poorly understood. Materials and M…
Article
Development of a Topical Emulgel Containing Tulsi and Neem Oils: A Novel Approach for Acne Management
Jyoti Sahu, Jisha Joseph, Vipul Alias Parab, Neeta Rai, Amit Lunkad, Pritam Bhore, Kirti Deshpande, Pallavi Kale, Ravi Kumar Sah, Jayesh Baldota
pp. 297–301 · DOI: 10.5530/ijpi.20260457 · Published Jan-Mar 2026
Objectives This research focused on formulating and assessing a silica-based herbal emulgel enriched with antimicrobial and anti-inflammatory agents, including tulsi (Ocimum sanctum) and neem (Azadirachta indica) oils, t…
Article
Formulation Development of Carvedilol Phosphate and Lisinopril Hydrochloride Bilayer Tablet using QbD
Kapil Kulkarni, Gitanjali Deokar
pp. 316–323 · DOI: 10.5530/ijpi.20260456 · Published Jan-Mar 2026
Introduction Lisinopril HCl (LH) and Carvedilol Phosphate (CP) combination bilayer tablet to be developed for the treatment of hypertension. Objectives To develop carvedilol phosphate and lisinopril hydrochloride bilayer…