Volume 16, Issue 2

Apr-Jun 2026 · pp. 1–761 · 54 articles

Volume: 16
Issue: 2
Published: Apr-Jun 2026
Pages: 1–761
Articles: 54
Sections: 3
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Original Article Review Article Research Article

In this issue

Original Article

Article
In vitro Insights: Investigating the Cytotoxic Properties of Curcuma caesia Roxb. and Aloe vera in situ Gel
Ankita Bohra, Thirupambaram Nataraja Sundaram Uma Maheswari
pp. 1–8 · DOI: 10.5530/ijpi.20260087 · Published Apr-Jun 2026
Background Chewing areca nuts is associated with the development of Oral Submucous Fibrosis (OSF), an oral disorder with malignant potential. While OSF has only recently begun to appear in Europe and North America, it re…
Article
Unveiling Healthcare Professionals' Insights via Knowledge, Attitude and Practice on Materiovigilance: A Multi-Centric Prospective Interventional Study
Sameer Mahabasha, Shashikala Wali, Mandati Santhosh Reddy
pp. 1–7 · DOI: 10.5530/ijpi.20260552 · Published Apr-Jun 2026
Background Materiovigilance is essential for ensuring safety and efficacy of medical devices by monitoring and reporting adverse events. Despite its importance, healthcare professionals’ Knowledge, Attitude, and Practice…
Article
Branded Versus Generic Antiepileptic Drugs in Epilepsy: Weighing Clinical Impact and Cost Effectiveness
Sandeep Kumar Yadav, Pratiksha Nagesh Kini, AnilKumar Kusnoor, Mujammil Mulla, Satish Karoli, Manjula Gudhoor
pp. 1–7 · DOI: 10.5530/ijpi.20260550 · Published Apr-Jun 2026
Background Epilepsy is a prevalent neurological disorder affecting around 50 million people globally, with a significant burden in low- and middle-income countries. The management of epilepsy requires long-term Antiepile…
Article
Formulation and Evaluation of Clindamycin Loaded Biodegradable Dental Cones for Sustained Drug Release in Post-Extraction Management
M Pradeep Kumar, E Ganga Prasanna, M Mahesh Yadav, B Jagadeesh Babu, C. Manjula, Pranav B Patil, Samarth Santosh Londhe, Suraj Ram Mashale, Rohan Ravsaheb Latwade
pp. 1–9 · DOI: 10.5530/ijpi.20260527 · Published Apr-Jun 2026
Objectives Dental diseases affect nearly 70% of the global population, often leading to extractions due to periodontitis, caries, or trauma. Post-extraction complications such as bacterial infections, pain, inflammation,…
Article
Novel Pyrimidine Derivatives: Microwave-Assisted Synthesis and Computational Insights Toward Anti-Inflammatory Activity
Vinayak Madhukar Gaware, Kiran Bhausaheb Dhamak, Vikas Damu Kunde, Mayur Trimbak Gaikar
pp. 1–10 · DOI: 10.5530/ijpi.20260056 · Published Apr-Jun 2026
Aim/Background This study focuses on the synthesis and evaluation of novel pyrimidine derivatives as potential anti-inflammatory agents. Materials and Methods The compounds were synthesized via a two-step process: conden…
Article
Evaluation of Myostaal SB in Osteopenia Management through Bone Remineralization: A Proof-of-Concept, Open-Label, Single-Arm Study in Middle-Aged and Older Adults
Mrudul Chitrakar, Mahesh Kumar Harit, Mukesh Chawda, Megha Nalawade, Vinay Pawar, Vedvati Bhapkar
pp. 1–10 · DOI: 10.5530/ijpi.20260038 · Published Apr-Jun 2026
Background Myostaal SB is a rational herbo-mineral Ayurveda formulation for management of Asthikshaya (~ osteopenia). It contains Kukkutandatvak Bhasma (Processed Hen-egg Shell), Asthisamhruta (Cissus quadrangularis), an…
Article
Cheminformatics-Based Evaluation of Drug-Likeness in Selected Phytochemicals from Vateria indica (Sarjarasa)
Rajeshwari Vijaykumar Kamat, Srivarshini Srinivasan, Asath Bharathy Parasuraman
pp. 1–8 · DOI: 10.5530/ijpi.20260570 · Published Apr-Jun 2026
Background Cheminformatics has emerged as a powerful tool in early-phase drug discovery, enabling the efficient evaluation of bioactive compounds from natural sources. Vateria indica (Sarjarasa), a medicinal plant used i…
Article
Screening of Phytochemicals as PIP5K1α Protein Inhibitors for Breast Cancer Treatment: A Bio Computational Study
Ahmed Mulfi Alharbi
pp. 585–589 · DOI: 10.5530/ijpi.20260049 · Published Apr-Jun 2026
Aim/Background Breast Cancer (BC) is one of the most common cancers affecting women globally. PIP5K1α catalyzes PtdIns-4,5-P2 (PIP2), a Precursor to PtdIns-3,4,5-P3 (PIP3), required for AKT activation. Overexpression of …
Article
Drug Utilization Evaluation of Proton Pump Inhibitors in the General Medicine Ward of a Tertiary Care Hospital
Shivalingayya Gadagayya Hiremath, Umesh Chaudhary, Giridhar Koratagere Sreekanth, Sai Keerthana Ravishankar, Manikanta Devaraj, Shailesh Yadav
pp. 590–598 · DOI: 10.5530/ijpi.20260331 · Published Apr-Jun 2026
Background Proton Pump Inhibitors (PPIs) are the most effective agents for managing acid related disorders. However, Inappropriate Prescribing of PPIs is becoming an issue of concern. Purpose To review proton pump inhibi…
Article
Formulation, Optimization, and Evaluation of Lornoxicam Medicated Chewing Gum Using Ion Exchange Resin Taste Masking
Kinjal Shah, Hemani Joshi, Shailvi Shah, Tejal Mehta
pp. 596–578 · DOI: 10.5530/ijpi.20260096 · Published Apr-Jun 2026
Background This study aimed to develop and evaluate a taste-masked Medicated Chewing Gum (MCG) of Lornoxicam (LXM) using Kyron T-114, a weak cation exchange resin, to improve palatability and patient compliance. LXM, a p…
Article
Drug Utilization Evaluation of Antibiotics in an Indian Hospital Setting: A Prospective Observational Study
Sanatkumar Bharamu Nyamagoud, Laxmi Bhimappa Totar, Hema Yadav, S M Shoaib Ahamed, Khandke Shruti Achyut, Vaishanavi Vanasakrithmath, R Ranjani, Tanushree R Bantanur, Chandan Ashok Naik, Shivani Mathapati, Spoorthi G Lakkannavar, K H Karthik
pp. 599–605 · DOI: 10.5530/ijpi.20260421 · Published Apr-Jun 2026
Background Rational drug use is essential to improving healthcare outcomes and minimizing risks such as antimicrobial resistance. This study evaluates prescription patterns in the General Medicine Department of an Indian…
Article
Preparative Separation, Identification and Characterization of N-Acylated Impurity in Ciprofloxacin Eye Drops Formulations Using 1D and 2D NMR Techniques
Bhupinder Kumar, Raju Mudhulkar, Sreedhar Gundekari, Surbhi Tiwari, Dama Venugopala Rao, Lakki Reddy Prakash, Ramakrishna Yadav Belly, Sandeep Kumar
pp. 606–617 · DOI: 10.5530/ijpi.20260460 · Published Apr-Jun 2026
Background Packaging, storage and transportation of under varying climatic conditions have the quality concern in the drug products. This study followed the observed unknown impurity of ciprofloxacin eye drop. Materials …
Article
In silico Analysis of 6, 6’-Dihydroxythiobinupharidine on the Enzymes Involved in Cognitive Impairment
Pranav Nayak, Mohammad Ali, DR Bharathi
pp. 618–624 · DOI: 10.5530/ijpi.20260468 · Published Apr-Jun 2026
Background Cognitive impairment signifies a reduction in mental abilities resulting from different factors like Alzheimer's disease leading to a diminished quality of life. Detecting it early and implementing interventio…
Article
DAVID and KEGG-Based Functional Enrichment Analysis of Breast Cancer Transcriptome: Mapping ECM Remodeling and Cell Division Pathways
Akram Ahmed Aloqbi
pp. 625–637 · DOI: 10.5530/ijpi.20260075 · Published Apr-Jun 2026
Background Breast cancer, affecting roughly 2.3 million people each year, stands as a major global health concern due to its molecular complexity across subtypes such as luminal, HER2-enriched, and triple-negative. These…
Article
Detection of Various Poison in Biological Sample Using High Performance Thin Layer Chromatography
Jayasutha Jayram, Jerad Suresh Ayyadurai, Jagadeesan Subramanian, Lokesh kumar Dhavanam Ramesh Babu, Mohanraj vadivelu, Naveen Raj Ravi Kumar, Silviya Jenifer John Bosco, Pravin Kumar Muthukumaresan, Sathya Samikkannu, Yashwan Babu, Raman Lakshmisundaram, Ramakrishnan Trichur Venkatakrishnan
pp. 645–653 · DOI: 10.5530/ijpi.20260608 · Published Apr-Jun 2026
Background Poisoning is a major public health issue in many countries, particularly in India, where exposures to pesticides, household agents, drugs, industrial chemicals, and animal toxins are common. Contributing facto…
Article
Computational Tool and Molecular Properties to Identify the Molecular Targets of Novel Benzimidazole Derivatives as Potential COX Inhibitors via in silico Approaches
Vinod Rajendra Tawate, Sanket Keshav Tambe, Shubham Popatrao Mankar, Nilima Mahesh Wani, Sneha Abhishek Vikhe, Manisha Dhondiram Sonawane, Rohit Jaysing Bhor
pp. 654–666 · DOI: 10.5530/ijpi.20260528 · Published Apr-Jun 2026
Background Using a variety of computational techniques, in silico studies allow for forecasting structural changes and how they would impact the pharmacological properties as well as the efficiency of these modifications…
Article
Evaluating the Safety and Efficacy of Hydroxyurea in Adult Sickle Cell Disease: A Prospective Observational Study
Rajesh Hadia, Kular Simran, Param Bhatt, Priyanka Yadav, Sarvajeet Khare, Cyril Sajan, Varunsingh Saggu, Hemraj Singh Rajput, Jitendra Lakhani
pp. 667–678 · DOI: 10.5530/ijpi.20260007 · Published Apr-Jun 2026
Background Sickle Cell Disease (SCD) is characterized by recurrent hospitalizations and painful Vaso-Occlusive Crises (VOCs). VOCs are prevalent and often necessitate hospital admissions. Aim and Objectives This study ai…
Article
Formulation and Evaluation of Antiacne Emulgel Using Aloe vera
Kamaladevi Kshatriya, Shivanand Swamy Panchayya Hiremath, Jathin Subhash Kalal, Fatima Sanjeri Dasankoppa, M Mahesh Yadav, Pradeep Bhimagouda Mirje, Jayatheertha Lokapur, Arpitha Lokapur, Rohan Ravsaheb Latwade, Pranav Babasaheb Patil
pp. 679–686 · DOI: 10.5530/ijpi.20260041 · Published Apr-Jun 2026
Introduction Emulgels are emerging as efficient topical drug delivery systems due to their dual-release mechanism, combining the benefits of both emulsions and gels. This system facilitates the enhanced delivery of hydro…
Article
Phyllanthin Topical Formulation with Penetration Enhancers Alleviates Imiquimod-Induced Psoriasis in Rats via Modulation of Inflammatory Biomarkers and Oxidative Stress Markers
Papiya Bigoniya, Vanita Chature
pp. 687–701 · DOI: 10.5530/ijpi.20260554 · Published Apr-Jun 2026
Background Psoriasis is a persistent inflammatory skin condition marked by abnormal epidermal proliferation and excessive keratinization, impairing effective drug absorption. To overcome these barriers, topical formulati…
Article
In vitro Antioxidant and Antiglycemic Effects of Malus domestica, Musa acuminata Colla, Mangifera indica, Citrus reticulata and Punica granatum Fruits Peel Extracts
C Reddy Prasad, Bibi Umeza, M Yuvaraj, A K Afzal Khan, Swapna R Nayaka, Thirunavukkarasu Jayaraman
pp. 702–707 · DOI: 10.5530/ijpi.20260059 · Published Apr-Jun 2026
Objectives This study aims to evaluate the anti-glycemic and antioxidant qualities of Malus domestica fruit (apple), Musa acuminata Colla fruit (banana), Mangifera indica fruit (mango), Citrus reticulata fruit (orange), …
Article
Cardiovascular Disease Risk Factors in Diabetics with and without Metabolic Syndrome in NAFLD Patients
Mohammad Shane Alam, Yahia Mjery, Kamal Ahmad, Yahia Ali Kaabi, Mohammad Suhail Akhter, Fakhra Jabeen, Jobran Mohammad Moshi, Alaa Ali Alhazmi, Md Intekhabul Haque, Saif Elden Babikar Abdalla, Mathkour Hazem
pp. 708–714 · DOI: 10.5530/ijpi.20260150 · Published Apr-Jun 2026
Background Globally, Non-Alcoholic Fatty Liver Diseases (NAFLD) is considered as the frequent chronic liver diseases strongly linked with metabolic dysfunction and cardiovascular risk specifically in Type 2 Diabetes Mell…
Article
Investigating the Prevalence of Pathogens and Drug Sensitivity in Catheter-Associated Urinary Tract Infections among ICU Patients: Insights from a Hospital-Based Cross-Sectional Study
Navpreet Singh Babbar, Rabinoor Singh, Arti Saini, Inderjeet Verma, Tarun Singh
pp. 715–721 · DOI: 10.5530/ijpi.20260403 · Published Apr-Jun 2026
Background Catheter-Associated Urinary Tract Infections (CAUTIs) pose a major concern in Intensive Care Units (ICUs) due to their association with prolonged catheterization and severe underlying conditions. These infecti…
Article
Formulation and Development of Euphorbia hirta Phytosomes Capsule for Treatment of Urinary Tract Infection
Supriya Waghmare, Shreeya Belwalkar, Amir Shaikh, Sidhhi Bansode, Akancha Kumari, Pooja Deshmane, Archana Nagare, Mohini Bhawane, Nitin Salunkhe
pp. 728–736 · DOI: 10.5530/ijpi.20260344 · Published Apr-Jun 2026
Background Euphorbia hirta, also known as the "asthma plant" or "snake weed," belongs to the Euphorbiaceae family. However, its oral use as a drug has certain limitations, such as low bioavailability and high first-pass …
Article
Green Metric Based Thin-Layer Chromatography Coupled with Mass Spectrometry to Identify Degradation Products of Lumateperone in Bulk and Formulation
Minal Ghante, Jyoti Tangde, Vidhya Bhusari, Arpana Patil, Payal Parmar
pp. 744–753 · DOI: 10.5530/ijpi.20260273 · Published Apr-Jun 2026
Objectives The goal of current work was to develop a new, simple, reliable and sensitive High-Performance Thin-Layer Chromatography (HPTLC) method for the estimation of lumateperone. This study also includes the identifi…
Article
Evaluation of Potentially Inappropriate Medication Use in Elderly Patients Using Beers Criteria in Community Pharmacy
G Guru., Jagadish kakadiya, S. Lavanya
pp. 754–761 · DOI: 10.5530/ijpi.20260524 · Published Apr-Jun 2026
Background With a mature worldwide population, the safety and appropriateness of the medications prescribed to older adults become ever more important. This study expected to determine the occurrence and categorization o…

Review Article

Review
Preclinical Models of Hepatic Injury: A Comprehensive Review of Chemically, Immunologically, and Pharmacologically Induced Liver Damage in Rat Models
Lokeshvar Ravikumar, Ramaiyan Velmurugan, Grandhi Surendra, P Sivasubramanian, Konatham Teja Kumar Reddy, Kanaka Durga Hanumanthu, R Venkateswararao, Dhanush Bellapu, Ramenani Hari Babu, Medishetti Swetha
pp. 1–18 · DOI: 10.5530/ijpi.20260603 · Published Apr-Jun 2026
The hepatic organ plays a vital role in maintaining the body's homeostasis by facilitating intricate biochemical reactions. Hepatic impairment, a pervasive condition in diverse liver disorders, poses considerable challen…
Review
Advances in Pulsatile Drug Delivery System: A Promising Strategy for Tailored Therapeutics in Modern Medicine- Review
Vuyyala Himachand, Tummadapu Bhavya, Uyyuri Kusuma, Prathi Sriya, Ravilisetty Pranavi, Nagineni Sudarshan Rao
pp. 1–10 · DOI: 10.5530/ijpi.20260159 · Published Apr-Jun 2026
The pulsatile drug delivery system is based on a reservoir system consisting of a drug-containing effervescent core and which are coated with a swelling membrane and a polymeric coating which is insoluble but water perme…
Review
From Seizure Control to Parasite Management: Antiepileptic Drugs and Neurocysticercosis
Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju, Thoppalada Yunus Pasha
pp. 1–8 · DOI: 10.5530/ijpi.20260556 · Published Apr-Jun 2026
Epilepsy is a chronic brain condition that affects more than 65 million people worldwide, with 30% of patients unable to control seizures, despite progress in Antiepileptic Drugs (AEDs). This article exploring the histor…
Review
Exploring Natural Bioactive Compounds for Radiation Countermeasure Properties: A Review
Toijam Sanjeev Lyngdoh, Dollyca Ningombam, Thangal Yumnamcha, Maibam Damayanti Devi
pp. 1–9 · DOI: 10.5530/ijpi.20260019 · Published Apr-Jun 2026
Radiation-induced toxicity poses significant challenges in radiation therapy, nuclear incidents, industrial, and other occupational applications. This review investigates the potentiality of natural bioactive compounds a…
Review
Engineering Smart Stimuli-Responsive Carriers for Precision Drug Delivery: Current Trends and Future Outlook
Yash Manoj Salve, Sukeshini Bharat Lote, Mayur Rajeshwar Dandekar, Isha Anil Mirzapure
pp. 1–12 · DOI: 10.5530/ijpi.20260507 · Published Apr-Jun 2026
Stimuli-Responsive Drug Delivery Systems (SRDDS), also regarded as smart” drug delivery systems, have emerged as a vital element of precision pharmaceutics, with the ability of a spatiotemporally controlled therapeutic r…
Review
Exploring the Historical Dissemination and Contemporary Resurgence of Monkeypox: A Comprehensive Examination of its Evolution, Global Impact, and Treatment Approaches
Madiha Sultana, Tushar Verma, Anju Jose, Swetha Ramesh, Sonia Singh
pp. 1–9 · DOI: 10.5530/ijpi.20260028 · Published Apr-Jun 2026
Monkeypox, an Orthopoxvirus genus zoonotic ailment, has resurfaced as a global public health issue, with outbreaks in 2022 and 2024 highlighting alterations in its epidemiology and transmission dynamics. This narrative s…
Review
Neuroprotection in Parkinson’s Disease: No More Status Quo
Mary Brenda Ogwang, Deepak Kumar Jha, Sandipan Chatterjee
pp. 371–383 · DOI: 10.5530/ijpi.20260022 · Published Apr-Jun 2026
Aim and Objectives This study aims to evaluate and analyze the concept of neuroprotection in Parkinson’s Disease (PD) by investigating the underlying mechanisms responsible for dopaminergic neuronal death. It explores ho…
Review
Integrating Molecular Modeling, Cheminformatics, and High-Throughput Screening: Paving the Way for the Future of Drug Discovery
Vaishnavi N. Thute, Sukeshini Lote
pp. 384–397 · DOI: 10.5530/ijpi.20260274 · Published Apr-Jun 2026
The process of drug discovery is slowly entering the era of change, wherein more efficient and effective approaches to identify the potential therapeutic compounds are sought. This review article explores the future of d…
Review
A Review on Wasp Venom as a Chemotherapeutic Agent in Different Types of Cancer
Arige Sirisha, Rama Rao Vadapalli, Penmatsa Srinidhi, Bathula Mahalakshmi, Muchakarla Sri Yagna, Kanuri Teja, T. Sowmya Sri
pp. 398–404 · DOI: 10.5530/ijpi.20260341 · Published Apr-Jun 2026
Cancer is the most leading cause of the death. Only few treatment options are available for treating the cancer such as radiation therapy, chemotherapy, and surgery. These treatment options can either used as single or c…
Review
The Multifaceted Potential of Tirzepatide in Metabolic and Non-Metabolic Disorders
Thalal Mohamed, Srimathi Mahadevan, Jayashri Vidya Prabhakaran, Sundari Venkatesan, Mohammed Fayaz, Vijayakumar Thangavel Mahalingam
pp. 405–413 · DOI: 10.5530/ijpi.20260349 · Published Apr-Jun 2026
Tirzepatide is redefining the treatment landscape for metabolic and non-metabolic disorders. By uniquely harnessing two critical hormonal pathways, the review provides comprehensive insights into how Tirzepatide’s dual m…
Review
Microplastic Pollution: The Escalating Environmental and Health Hazards Threatening Ecosystems and Human Well-being
Harshith Naganna, Kumble Prakash Rao Tejas Rao, Tejaswi Hiremarali Lokanathan, Mathada Vamadevaiah Ravishankar
pp. 414–424 · DOI: 10.5530/ijpi.20260360 · Published Apr-Jun 2026
Plastic is found with its wide applications worldwide to fulfil our domestic and industrial needs. Its vast diversified usability and unscientific disposal patterns cause tireless accumulation of various forms of plastic…
Review
Mouth Dissolving Tablets: Bridging Laboratory Innovations and Consumer Convenience
Kirtimaya Mishra, Asra Jabeen, Swetha Vegesna, Gowri Sankar Chintapalli, Debasis Patra, Diptimayee Jena
pp. 425–430 · DOI: 10.5530/ijpi.20260373 · Published Apr-Jun 2026
Mouth Dissolving Tablets (MDTs) are considered as a novel approach to improvize patient compliance and fast drug delivery. They constitute a significant improvement in pharmaceutical technology. The dissertation explores…
Review
A Brief Review of Drug Delivery System Used in Breast Cancer Therapies
Niyati Shah, Ritu Sapra, Maitry Suthar, Piyushkumar Sadhu, Nisha Mandloi, Mamta Kumari, Chitrali Talele, Chintan Aundhia
pp. 431–441 · DOI: 10.5530/ijpi.20260010 · Published Apr-Jun 2026
Breast cancer remains a significant global health challenge, necessitating innovative therapeutic approaches to improve patient outcomes. Drug delivery systems have emerged as promising tools to enhance the efficacy and …
Review
Synthesis and Biomedical Applications of Titanium Dioxide Nanoparticles a Literature Review on Current Advances and Future Directions
Kalyani Andraskar, Krishna Raj, Abhay Tiwary, Poonam Lal
pp. 442–449 · DOI: 10.5530/ijpi.20260430 · Published Apr-Jun 2026
Nanoparticles of Titanium Dioxide (TiO₂) have also become an essential element of nanomedicine because of their multifunctionality and wide use in medicine. This review compiles current advances in the synthesis, functio…
Review
Real-Time Release Testing (RTRT) in Pharmaceutical Quality Control: Current Practices and Future Prospects
Mayur Rajeshwar Dandekar, Isha anil Mirzapure, Yash Manoj Salve, Deepak Khobragade
pp. 450–461 · DOI: 10.5530/ijpi.20260432 · Published Apr-Jun 2026
Real-time release Testing is now considered one of the breakthroughs in pharmaceutical quality control, replacing the old batch-testing paradigms with a modern, real-time, more efficient, data-driven approach. RTRT combi…
Review
The Role of GMP Audits in Ensuring Drug Quality and Safety in Drugs
Mayur Dandekar, Deepak khobragade, Yash Salve, Sakshi Mandhane, Isha Mirzapure
pp. 462–469 · DOI: 10.5530/ijpi.20260480 · Published Apr-Jun 2026
The importance of GMP audits in ensuring the quality, safety, and efficacy of pharmaceuticals is unmistakable. These audits are systematic appraisals of facilities, processes, personnel, documentation, and quality manage…
Review
Vaccines: A Comprehensive Review of Vaccine Evolution and mRNA Technology
Shweta Bhandari, Rahul Trivedi, Rajesh Hadia, Ajay kumar Saini, Vishal Garg, Ram Singh
pp. 470–475 · DOI: 10.5530/ijpi.20260588 · Published Apr-Jun 2026
Vaccines have saved millions of lives and reduced the spread of infectious diseases, thereby transforming global health. This comprehensive overview traces the historical evolution of vaccines-from ancient inoculation pr…
Review
Exploiting MMR Pathways in Plasmodium as Novel Antimalarial Targets: Opportunities and Challenges
Mohammed Tarique, Ziaullah Sain, Yusuf Ahmad
pp. 476–489 · DOI: 10.5530/ijpi.20260154 · Published Apr-Jun 2026
Malaria, which is caused by Plasmodium parasites, remains a major international health issue, especially in developing countries. The problem of drug resistance has become a major concern, especially with respect to arte…
Review
Juvenile Animal Toxicity Studies of Pharmaceuticals and Industrial Chemicals for Regulatory Preclinical Safety Assessment
Rohit Bairagi, Ruchi Suryawanshi, Suankit Harane, Milind Umekar, Vinita Kale
pp. 490–499 · DOI: 10.5530/ijpi.20260578 · Published Apr-Jun 2026
Juvenile Animal toxicity Studies (JAS) are conducted to evaluate potential safety risks, particularly those affecting postnatal growth and development, that may not be detectable through standard toxicity studies or pedi…
Review
L-Carnitine in Reproductive Health: A Narrative Review on Its Pharmacological Role in Enhancing Fertility Outcomes
M Varsha, Sarumathy Sundararajan
pp. 500–506 · DOI: 10.5530/ijpi.20260065 · Published Apr-Jun 2026
L-Carnitine, a naturally occurring quaternary amine, plays a crucial role in mitochondrial fatty acid transport and energy metabolism. This narrative review explores the pharmacological significance of L-Carnitine in rep…
Review
Navigating the Landscape of OTC Drug Utilization and Regulatory Challenges in India: Insights Review
Blessy K George, Jaidev Kumar, Sunil Kumar, Balakeshaw Ramaiah
pp. 507–516 · DOI: 10.5530/ijpi.20260514 · Published Apr-Jun 2026
This review article on utilization and regulations of OTC drugs aims to highlight the significance of establishing legal policies on "OTC medicines" in India by outlining the potentially harmful effects of these medicati…
Review
Metabolism of mRNA Therapeutics: Insights into Pharmacokinetics and Toxicology
Yogita Shinde, Tanishka Prakash Sharma, Archana Shaha, Rakesh Chaudhari, Rashmi Rajeghorpade, Dipali Talele, Chitrali Talele
pp. 517–522 · DOI: 10.5530/ijpi.20260539 · Published Apr-Jun 2026
Messenger RNA (mRNA) therapies are a groundbreaking treatment for various conditions, including infectious diseases, cancer, and genetic disorders. This review examines the processing of mRNA therapeutics in the body, fo…
Review
Cancer Stem Cells in Breast Cancer: Unlocking New Frontiers in Therapeutic Strategies
Qamre Alam, Reem Saeed Alazragi, Alaa Al-Kathiri, Alrayan Abass Albaz, Jawaher Mohammad Alshehri, Fatimah Ali Alsaffar, Dalia Alammari, Saleh Alqahtani
pp. 523–535 · DOI: 10.5530/ijpi.20260153 · Published Apr-Jun 2026
This review thoroughly examines Breast Cancer Stem Cells (BCSCs) discussing their involvement, in tumor advancement and spread and their resistance to treatment while also discussing methods for targeting them for elimin…
Review
The Impact of Nanoparticulate Drug Delivery Systems on Cancer Therapy and the Role of Artificial Intelligence
Santosh Kumar Dash, Ashutosh Padhan, Abdul Sayeed Khan, Tusara Kanta Behera, Sachhidananda Mohapatra, Sulagna Parta, Ranjan Kumar Sahoo
pp. 536–540 · DOI: 10.5530/ijpi.20260109 · Published Apr-Jun 2026
Cancer remains a leading cause of global mortality. Conventional treatments such as chemotherapy, radiation, and surgery often lead to severe side effects and limited effectiveness. Nanoparticulate Drug Delivery Systems …
Review
Gene Editing Frontiers: CRISPR-Cas9 as a Novel Therapeutic Approach for Autism Spectrum Disorder
Arya Deshmukh, Mujibullah Sheikh, Akanksha Dange
pp. 541–560 · DOI: 10.5530/ijpi.20260081 · Published Apr-Jun 2026
Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by deficits in social interaction and communication alongside repetitive behaviors and restricted interests. Despite substantia…
Review
Chiral Switch in Antidepressants: A New Frontier for Safer and More Effective Personalized Therapies: A Review
Nandula Lavanya, Rashmi Nelligare Gopalakrishna
pp. 561–568 · DOI: 10.5530/ijpi.20260469 · Published Apr-Jun 2026
Advancements in drug development emphasize enhancing efficacy, reducing side effects, and tailoring treatments to individual patient needs. Conventional antidepressant therapies often face limitations such as delayed ons…

Research Article

Article
Modulating Metabolic and Cardiovascular Adverse Effects of Olanzapine with Theobroma cocoa a Preclinical Insight into Synergistic Cardioprotection
Varsha Aniket Patole, Santosh Bhausaheb Dighe, Sapna Baban Khemnar, Gaurao subhash damare, Vaibhav vitthal bhone, Shweta Shantaram Jadhav
pp. 579–584 · DOI: 10.5530/ijpi.20260113 · Published Apr-Jun 2026
Background Olanzapine, a widely prescribed atypical antipsychotic, is associated with significant cardiometabolic side effects, including hypertension, dyslipidaemia, oxidative stress, inflammation, and QT interval prolo…
Article
Comparison of Dermatology Life Quality Index and Skindex-16 Questionnaires in Breast Cancer Patients with Radiation Dermatitis
Rohith Kuppusamy, Keerthika Devaraj, Gayathri Thiruvengadam, Nandhakumar Kannan, Mohamed Ashik Ahamed Ibrahim, Sriniga Venkatesh, Raman Lakshmisundaram, Sindhu Selvam, Ruthresh Jaisankar, Aswin Venkadesh Ramamoorthy Renuga, Jayasutha Jayram, Satish Srinivas Kondaveeti
pp. 722–727 · DOI: 10.5530/ijpi.20260607 · Published Apr-Jun 2026
Background Radiation Dermatitis (RD) is the most common adverse effect of radiation therapy among the cancer patients, which has the potential to lower patients' quality of life. This study aimed to assess the health-rel…
Article
Prevalence of Concomitant Use of Angiotensin Converting Enzymes Inhibitors and Angiotensin Receptors Blockers: A Retrospective Study
Alhanouf Alhawiti, Mohamed TS Saleem, Ahmed Hasan Abdelazeem, Tahani Al Rahbeni
pp. 737–743 · DOI: 10.5530/ijpi.20260138 · Published Apr-Jun 2026
Background A retrospective study was conducted using Electronic Health Records (EHRs) from several hospitals in Saudi Arabia. Materials and Methods All hypertensive patients who visited the hospitals between 2016 and 202…