Volume 16, Issue 3

Apr-Jun 2026 · pp. 770–1201 · 34 articles

Volume: 16
Issue: 3
Published: Apr-Jun 2026
Pages: 770–1201
Articles: 34
Sections: 3
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article Research Article

In this issue

Review Article

Review
Association of SIRT1 Gene Polymorphisms with Type 2 Diabetes Mellitus and its Complications: A Systematic Review and Meta-Analysis
Harikumar Selvaraj, Santhini Gopalakrishnan
pp. 836–842 · DOI: 10.5530/ijpi.20260035 · Published Apr-Jun 2026
Sirtuin 1 (SIRT1) is a metabolic regulator implicated in insulin signaling, inflammation, and mitochondrial function. Several SIRT1 gene polymorphisms have been linked to Type 2 Diabetes Mellitus (T2DM) and its complicat…
Review
Medications and Bone Health: A Comprehensive Review of Skeletal Risks and Therapeutic Approaches
Kaniga Pandi, Binoy Varghese Cheriyan, Dharshan Murali, Nesayan Boobalan, Jeevitha Harikrishnan, Deepshikaa Kannan, Lini Priyadharshini Christopher Jebaraj, Shamyuktha Munuswamy, Shagul Hameed Manaksha, Sriharan Sekar, Vimal Palaniraja, Naresh Sivagnanam, Revathy Kumar
pp. 843–858 · DOI: 10.5530/ijpi.20260055 · Published Apr-Jun 2026
Bone-drug interactions represent a critical yet often under recognized domain within clinical pharmacology due to their long-term implications on skeletal integrity. The human skeletal system relies on a tightly regulate…
Review
Research Progress on the Use of the Traditional Chinese Formula Si-Jun-Zi Tang in the Prevention and Treatment of Schizophrenia
Teng Ma
pp. 859–862 · DOI: 10.5530/ijpi.20260112 · Published Jan-Mar 2026
Schizophrenia is a chronic and severe psychiatric disorder characterized by positive symptoms, negative symptoms, and cognitive deficits, imposing profound burdens on patients, families, and healthcare systems worldwide.…
Review
Regulatory Intelligence in Emerging Pharma Markets: Bridging Innovation with Compliance
Isha Anil Mirzapure, Manish Deshmukh, Manjusha Bhange, Yash Manoj Salve, Mayur Rajeshwar Dandekar
pp. 863–879 · DOI: 10.5530/ijpi.20260500 · Published Jan-Mar 2026
The delayed access to innovative medicinal products such as orphan drugs and biologics and mRNA vaccines and advanced therapy medicinal products ATMPs occurs in numerous developing nations because of disjointed regulator…
Review
Exploring Novel Emerging Therapeutic Strategies for Parkinson’s Disease: A Narrative Review
Vishal Kulkarni, R T Sai Kumari, Sanjunath Satteppa Muchandi, Sanatkumar Bharamu Nyamagoud, H M Nanjappaiah, Vishwanath Jagadevappa Hooli, Sangamesh Sharanbasappa Tadkal, Prasad Nijaguni Bali
pp. 880–884 · DOI: 10.5530/ijpi.20261067 · Published Jul-Sep 2026
Parkinson's Disease (PD) is a common neurodegenerative disorder. It is defined by a progressive loss of dopamine neurons in the substantia nigra pars compacta and neurodegeneration, which eventually results in a decrease…
Review
In vitro Models for Studying Drug Metabolites and Metabolizing Enzymes: A Comprehensive Review
Durga Pani Kumar Anumolu, Bugga Veena, Syed Sara Afreen, Jahnavi Bandla, KNV. Chenchu Lakshmi, Veera Shakar Pulusu
pp. 885–891 · DOI: 10.5530/ijpi.20260116 · Published Jul-Sep 2026
Background In vitro assays play a crucial part in evaluating the metabolic fate of drug candidates and understanding the activity of drug-metabolizing enzymes. Materials and Methods Model systems including Hepatocytes, S…
Review
Regulatory Roadmap for R&D to Market the New Drugs in India with a Special Emphasis on the NDCT Rule 2019 and the Drug and Cosmetic Act
Pragati Jain, Abhinav Srivastava, Anurag Verma, Urvashi Saxena
pp. 892–909 · DOI: 10.5530/ijpi.20260186 · Published Jul-Sep 2026
The stepwise overview of the regulatory approval pathway for new drugs in India, focusing on requirements and key forms mandated by the NDCT Rules, 2019. It explains how new drugs are legally defined and categorized, set…
Review
Targeting the Tumor: Molecular Pathways and Therapeutic Frontiers in Breast Cancer
Mohammed Tarique, Abdulmajeed Abdulghani Abdulmajeed Sindi, Nawal Helmi, Qamre Alam
pp. 910–918 · DOI: 10.5530/ijpi.20260225 · Published Jul-Sep 2026
Breast Cancer (BC) is the leading cause of mortality in the majority of women around the globe. It stands as one of the most common types of cancer after non-melanoma skin cancer. Contemporary oncology distinguishes BC u…

Original Article

Article
Establishing and Validating: A DOE Approach of a Novel Quantitative Method for the Simultaneous Estimation of Methotrexate, Curcumin, and Etodolac Using RP-HPLC Method
Jitendra Pratap Singh, Deepak Singh, Gaurav Tiwari
pp. 953–960 · DOI: 10.5530/ijpi.20260053 · Published Apr-Jun 2026
Background It is very hard to measure Methotrexate (MTX), $(CUR), and Etodolac (ETO) all at the same time because they have very different chemical and physical qualities and might work well together in inflammation and …
Article
Protective Effects of Captopril and Spironolactone against Hyperglycemia-Induced Oxidative Stress in KGN Cells: Evidence from Viability and Mitochondrial Assays
Chandana, Mohammad Ali, D.R Bharathi
pp. 978–983 · DOI: 10.5530/ijpi.20260012 · Published Apr-Jun 2026
Background Diabetes-induced oxidative stress adversely impacts ovarian granulosa cells, affecting fertility in women. This study explores the protective effects of captopril and spironolactone, two RAAS inhibitors, again…
Article
Exploring the Use of Traditional Herbs in Cardiovascular Patients Adverse Effects and Treatment Outcomes at King Salman Hospital, Hail City
Nasrin E. Khalifa, Ghaida Fayez, Jomana Altamimi, Hanan Alanazi, Maha Soud, Ryam Alanazi, Haya Alshammari
pp. 990–996 · DOI: 10.5530/ijpi.20260537 · Published Apr-Jun 2026
Background Although herbal remedies are commonly utilized among cardiovascular patients in Saudi Arabia, regional data from Hail remains limited. Objective: The present research investigated prevalence, patterns, motivat…
Article
Exploration of Bacterial Endophytes from the Whole Plant of Mimosa pudica: Isolation, Identification, and Biochemical Characterization
Kirti Ganeshprasad Sahu, Deepak Shamrao Khobragade, Ram Dnyaneshwar Bawankar
pp. 997–1004 · DOI: 10.5530/ijpi.20260346 · Published Apr-Jun 2026
Background Endophytes are non-pathogenic microorganisms that reside within plant tissues without causing symptoms of infection. Mimosa pudica Linn., a sensitive plant with a long history of traditional medicinal use for …
Article
Fabrication and in vitro-ex vivo Evaluation of Diclofenac Sodium Transdermal Patches for Enhanced Skin Compatibility
Muhammad Abid Mustafa, Asad Majeed Khan, Ayesha Atif, Fatima Wajid, Nasir Ali, Khuram Ashfaq, Muhammad Abuzar Ghaffari, Nabeela Jabeen, Rabbia Nasir, Faiza Arshad, Laiba Kaleem
pp. 1005–1017 · DOI: 10.5530/ijpi.20260145 · Published Jan-Mar 2026
Background Transdermal drug delivery systems provide a sophisticated and patient-compliant strategy for arthritis management by maintaining consistent plasma concentrations, reducing dosing frequency, and minimizing gast…
Article
Dual-Release Gastroretentive System of Tizanidine Hydrochloride: Formulation and Evaluation of Floating Bilayer Tablets
Saritha Medapati, Vandana Rani Malakar, Naga Mallikarjun Pyda, Prasanthi Pakalapati, Sheik Jakir Hussain Mustaq, Seetha Devi Alla
pp. 1018–1024 · DOI: 10.5530/ijpi.20260098 · Published Jul-Sep 2026
Background To formulate and assess floating bilayer tablets of Tizanidine Hydrochloride (TZN) intended to extend gastric retention and for sustained release of the drug. Materials and Methods Six bilayered floating table…
Article
Pharmacognostical and Pharmaceutical Analysis of Amalaka Rasayana Churna-A Polyherbal Ayurveda Formulation
Amal Satheesa Chandran, Ashok Patil, Sanjiv Kumar, Padmaveer Puthiyidam Sreenikakumar, Sreeja Kaimal Vijayakumara Kaimal
pp. 1025–1031 · DOI: 10.5530/ijpi.20260117 · Published Jul-Sep 2026
Background Amalaka Rasayana Churna (ARC) is a polyherbal Ayurvedic formulation consisting of Amalaki (Emblica officinalis Gaertn.), Pippali (Piper longum L.), Ghrita (ghee), Madhu (honey), and Sarkara (sugar) traditional…
Article
Repeated Dose 90-Day Oral Toxicity Study of Kushta-e-Faulad: A Traditional Unani Hematinic Agent
Gulam Mohammed Husain, Divya Kodavath, Tasleem Ahmad, Younis Iftikhar Munshi, Mohd Urooj
pp. 1032–1038 · DOI: 10.5530/ijpi.20260047 · Published Jul-Sep 2026
Background Kushta is an ultra-fine powdered product in Unani medicine, created through calcination of animal, metals and mineral substances. Kushta-e-Faulad is a traditional compound Unani formulation to manage Su’al-Qin…
Article
Investigating Pharmacists Perceptions and Engagement with Generative AI in Everyday Contexts and Decision-Making
Lakshmipriya Bachina, Kanagala Anusha, Niveditha Pallerla
pp. 1039–1045 · DOI: 10.5530/ijpi.20260086 · Published Jul-Sep 2026
Aim/Background Generative Artificial Intelligence (Generative AI or Gen AI) is a subset of Artificial Intelligence that produces multimedia content, including text, images, stories, videos, music, and other digital artif…
Article
Preparation and Evaluation of PLGA-Safinamide Mesylate Nano Particles for the Management of Parkinson’s Disease
Veena Kalyani Sunkanna, Vedamurthy Joshi, Anoop Manjunath
pp. 1046–1055 · DOI: 10.5530/ijpi.20260088 · Published Jul-Sep 2026
Aim/Background Parkinson’s Disease (PD) is second most common chronic ongoing neurodegenerative disease recorded in ageing population, which is primarily treated with medications that either replace dopamine or mimic its…
Article
Design, Synthesis, Molecular Docking, and in vitro Anti-Inflammatory Evaluation of Novel Benzimidazole Derivatives as Potential COX-2 Inhibitors
Neha Shyam Bora, Mayur Shivaji Bhosale, Amol Sambhaji Balsane, Vikrant Murlidhar Dhamak, Rohit Jaysing Bhor, Sagar Magar Dattatraya, Sanket KeshavTambe
pp. 1056–1063 · DOI: 10.5530/ijpi.20260097 · Published Jul-Sep 2026
Background Cyclooxygenase-2 (COX-2) is a key enzyme involved in inflammation, making it an important target for anti-inflammatory drug discovery. Derivatives of benzoimidazole are well recognized for diverse pharmacologi…
Article
Imposter Syndrome and Adoption Readiness for Network Pharmacology: The Mediating Role of Training and Moderating Role of Peer Support
Tiyagura Nagaraja Kumari, Bachunaga Kishore Babu, Daniel Pilli, Repalle Giddaiah, K. Sowjanya
pp. 1064–1077 · DOI: 10.5530/ijpi.20260100 · Published Jul-Sep 2026
Background Network pharmacology provides a comprehensive systems-level framework for the domains of drug discovery, precision medicine, and the repurposing of therapeutics. Despite the rapid advancement of technology, th…
Article
A New Stability-Indicating RP-HPLC Method for the Simultaneous Estimation of Remogliflozin and Teneligliptin in Bulk and Pharmaceutical Dosage Form
Badupula Sravan Kumar, Roopa Redamala
pp. 1078–1089 · DOI: 10.5530/ijpi.20260115 · Published Jul-Sep 2026
Aim To estimate Remogliflozin and Teneligliptin simultaneously in bulk and pharmaceutical dosage forms, including forced degradation studies, a simple, Robust, and Stability-Indicating (RP-H-P-L-C) method has been develo…
Article
Medical Device Regulation in India: Comparative Stakeholder Analysis and Policy Recommendations for CDSCO
Dasharath Muljibhai Patel, Shipra Vijayesh Pandey
pp. 1090–1097 · DOI: 10.5530/ijpi.20260127 · Published Jul-Sep 2026
Objectives India's rapidly growing medical device industry, which is expected to rank among the biggest in the world in the next ten years, is heavily regulated by the Central Drugs Standard Control Organization (CDSCO).…
Article
Stability-Indicating HPLC Method for Quantification of Isotretinoin Impurities in Complex Semi-Solid Dosage Forms
Emmanuel Madugula, Niranjan Patra, Tinku Baidya
pp. 1098–1103 · DOI: 10.5530/ijpi.20260132 · Published Jul-Sep 2026
Background Isotretinoin, a retinoid derivative of vitamin A, is widely used for the treatment of severe recalcitrant acne, reduces sebum production, suppresses sebaceous gland activity, and exhibits potent anti-inflammat…
Article
“Development and Validation of Questionnaires to Assess Community Pharmacists’ Knowledge, Attitude, and Willingness to Practice (KawP) Vaccination Services: Advancing Immunisation Efforts”
Gangayya Jagadish Wakkundmath, Madiwalayya Shivakantayya Ganachari, Geetanjali Salimath
pp. 1104–1109 · DOI: 10.5530/ijpi.20260144 · Published Jul-Sep 2026
Background The presence of community pharmacists in the field is particularly important because they operate on the front line of contact with the population when providing the best health care. Evaluating their Knowledg…
Article
Sustainable and Enhanced Production of Glucose Oxidase by Aspergillus niger Using Pineapple Rind as an Economical Substrate for Biomedical and Biosensor Applications
Harika Gadiparthi, Hema Gayatri Simhadri, Chandrasekhar Chanda
pp. 1110–1116 · DOI: 10.5530/ijpi.20260156 · Published Jul-Sep 2026
Objectives Glucose Oxidase (GOx) is a essential enzyme used in several industries, including food, pharmaceuticals, and biotechnology. However, commercial-scale production continues to face challenges due to high process…
Article
Evaluating the Awareness, Perceptions, and Practices of Clinical Trial Sponsors Regarding the Utilization of Human Leftover Biospecimens in Future Research
Kurubara Amaresh, Madiwalayya Shivakantayya Ganachari, Revana Siddappa Devarinti
pp. 1117–1122 · DOI: 10.5530/ijpi.20260171 · Published Jul-Sep 2026
Background Surplus human biospecimens serve as a valuable resource for advancing scientific discovery, and their ethical management is essential for maintaining integrity in biomedical research. Clinical Trial Sponsors h…
Article
Design and Optimization of Arginine-Loaded Nutraceutical Nanoparticles via Face-Centered Central Composite Approach
Vijay Sharma, Maneesh Kumar Singh, Gurvinder Pal Singh, Gyanendra Kumar Sharma, Navneet Verma
pp. 1123–1134 · DOI: 10.5530/ijpi.20260567 · Published Jul-Sep 2026
Aim/Background The aim of the present study was to develop and optimize a dosage form of L-arginine as a nanoparticle for prolonged release. The Quality by Design (QbD) approach was employed to develop and optimize the d…
Article
Unveiling the Challenges in Topical Corticosteroid Usage: Insights from Pharmacists and Physicians
Sreeraj Kandoth, Narayana Charyulu Rompicherla, Sarath Chandran Chadrashekar Shenoy, Uday Venkat Mateti, Juno Jerold Joel, Sarin Shyamala Mohanan
pp. 1135–1142 · DOI: 10.5530/ijpi.20260205 · Published Jul-Sep 2026
Background Topical Corticosteroids (TCs) are widely prescribed for managing dermatological conditions due to their efficacy in reducing inflammation and related symptoms. However, misuse, suboptimal prescribing practices…
Article
Structural Biology and Viral Genetics of the DENV-1 NS5 Methyltransferase Domain: Functional Insights and Epitope Mapping
Ghadeer Bukhari
pp. 1143–1151 · DOI: 10.5530/ijpi.20260265 · Published Jul-Sep 2026
Background The NS5 protein in Dengue Virus Serotype-1 (DENV-1) is a multifunctional enzyme that is crucial for the virus to reproduce and evade the immune system. One important part of NS5 is the methyltransferase (MTase…
Article
A Prospective Comparative Study of Rituximab Monotherapy and Dexamethasone-Cyclophosphamide Pulse Therapy in Patients Diagnosed with Pemphigus vulgaris
Rametrika Saha, Veeranagoud Biradar, Spoorti Konkani, Mandati Santhosh Reddy, Bhavana Doshi
pp. 1152–1157 · DOI: 10.5530/ijpi.20260228 · Published Jul-Sep 2026
Background Pemphigus vulgaris (PV) is a severe autoimmune blistering disorder traditionally managed with corticosteroids, which are associated with significant adverse effects; as a result, alternative therapies such as …
Article
Anticoagulant and Pharmacokinetic Evaluation of Apixaban Sublingual Tablets in Wistar Rats
Pradeep Kumar, Vaibhav Rastogi
pp. 1158–1169 · DOI: 10.5530/ijpi.20260288 · Published Jul-Sep 2026
Background Apixaban is a novel oral anticoagulant widely used in the treatment and prevention of thromboembolic disorders. However, oral administration is associated with delayed onset of action and inaccurate gastrointe…
Article
Mapping Adverse Drug Reactions burden in Mono- and Dual-Antiplatelet Therapy: A Prospective Hospital-Based Study in CAD Patients
Mandati Santhosh Reddy, Madiwalayya Shivakantayya Ganachari
pp. 1170–1175 · DOI: 10.5530/ijpi.20260262 · Published Jul-Sep 2026
Background Antiplatelet therapy is central to managing Coronary Artery Disease (CAD), but benefits are offset by Adverse Drug Reactions (ADRs), particularly bleeding. Objectives To compare the causality, severity, and pr…
Article
Comparative Evaluation of Silver, Copper, and Hybrid Polymer Antimicrobial Coatings on High-Touch Hospital Door Handles Under Real-World Conditions
Nawal Helmi, Hanadi Mohammed Baeissa, Israa Jameel Hakeem, Dalia Muhammed Alammari
pp. 1176–1182 · DOI: 10.5530/ijpi.20260009 · Published Jul-Sep 2026
Background High-touch surfaces in healthcare settings can act as reservoirs for microbial transmission, underscoring the need for durable antimicrobial surface interventions that remain effective under realistic use cond…

Research Article

Article
Antibiotic Misuse in Pediatric Populations: Causes, Consequences, and Strategies for Mitigation
Susmita Mandal, Deep Shende
pp. 984–989 · DOI: 10.5530/ijpi.20260045 · Published Apr-Jun 2026
Background The increasing risk of antibiotic resistance is a major worldwide health concern, with especially dire repercussions for children. The purpose of this study is to investigate the causes, effects, and preventat…