Volume 16, Issue 4

Oct-Dec 2026 · pp. 1202–1724 · 50 articles

Volume: 16
Issue: 4
Published: Oct-Dec 2026
Pages: 1202–1724
Articles: 50
Sections: 2
ISSN: Print - 2230-973X, Online -2230-9713
Journal: IJPI

Review Article Original Article

In this issue

Review Article

Review
AI-Based Approaches for Early Detection and Prevention of Diabetes
Neeta Rai, Poonam R Inamdar, Jisha joseph, Omkar Kokate, Ajinkya Mote, Shivanjali Tagade, Narendra Mukesh Vishwakarma, Aryan Mangesh Vishwakarma, Pooja Malviya, Anjita Singh Thakur, Viren Mandlecha, Piyush Jangid
pp. 1202–1209 · DOI: 10.5530/ijpi.20260093 · Published Oct-Dec 2026
Diabetes mellitus is a chronic and multifaceted disorder representing a major global health concern. The two primary forms, Type 1 and Type 2 diabetes, differ in origin and progression yet share serious complications, in…
Review
Bridging the Digital Gap: A Comparative Analysis of Electronic Regulatory Submission Systems in India and Established Markets
Mukesh Kumar Malik, Rekha Dhull, Raman Sureshkumar
pp. 1210–1215 · DOI: 10.5530/ijpi.20260134 · Published Oct-Dec 2026
Regulatory agencies around the world now rely heavily on electronic submissions, which improve operational effectiveness and compliance. It is crucial to evaluate how developing economies, especially India, conform to st…
Review
Biosensor-Based Innovations in Therapeutic Drug Monitoring: Bridging Traditional Methods and Precision Medicine
K Pavani Reddy, Katika Nizamuddin, Haranath Chinthaginjala, E Bhargav, Kavadi Kartikeya, Kothakota Kousar, Chennavaram Kurmila, Maddileti Repollu
pp. 1216–1230 · DOI: 10.5530/ijpi.20260148 · Published Oct-Dec 2026
Therapeutic Drug Monitoring (TDM) serves as a crucial component of personalized medicine, allowing healthcare providers to tailor drug dosages according to individual pharmacokinetic and pharmacodynamic profiles, thereby…
Review
Toward Application of Microsponges for Topical Drug Delivery: A Review
Rajashree Shashidhar Masareddy, Archana Sidagouda Patil, Ankita Kashinath Patil, Ravikiran Ramachandra Kanabargi, Pooja Prakash Rayanade
pp. 1231–1243 · DOI: 10.5530/ijpi.20260179 · Published Oct-Dec 2026
The sunscreen industry is a growing industry because of the increasing need for skin protection and increased awareness of the harmful effects of sunlight by the consumer. Day by day more effective sunscreen actives, nov…
Review
Pharmaceutical Microbiology: Navigating Future Challenges and Innovations
Ritu Sapra, Maitry Suthar, Khushboo Arora, Aakansha Meval, Akanksha Patel, Niyati Shah
pp. 1244–1250 · DOI: 10.5530/ijpi.20260188 · Published Jul-Sep 2026
Pharmaceutical microbiology is at a pivotal moment as emerging technologies, global health demands, and evolving regulatory expectations reshape the landscape of drug development and manufacturing. This field, which trad…
Review
Smart Implants: Transforming Drug Delivery Systems
Sakshi Wankhede, Anil Pethe
pp. 1251–1261 · DOI: 10.5530/ijpi.20260195 · Published Oct-Dec 2026
Smart implants represent an advanced class of biomedical devices integrating sensing systems, microelectronics and targeted drug release mechanisms. These technologies enable adaptive, real time drug delivery based on ph…
Review
Artificial Intelligence and Machine Learning in GRDDS
Balijepalli Murali Krishna, Chandra Sekhar Patro, Ch. Taraka Ramarao
pp. 1262–1272 · DOI: 10.5530/ijpi.20260224 · Published Oct-Dec 2026
Gastroretentive Drug Delivery Systems (GRDDS) are designed to remain in the stomach for extended periods, releasing their drug payload in the gastric environment. These platforms are especially beneficial for drugs with …
Review
Leishmaniasis: Complexities and Burden of a Vector-Borne Neglected Tropical Disease
Mohammed Tarique, Mohiuddin Khan Warsi, Mohd Imtiaz Nawaz, Osama Ali Almuzaini, Mahjabeen Rahmani, Mohammad Azhar Kamal
pp. 1273–1284 · DOI: 10.5530/ijpi.20260227 · Published Oct-Dec 2026
This review examines key dimensions of leishmaniasis, including its epidemiology, transmission dynamics, treatment options, and the major challenges and opportunities for control particularly through integration with oth…
Review
Integrated Risk Assessment of Manufacturing Processes, Safety, and Nitrosamine Contaminants in the Pharmaceutical Industry: A Comprehensive Review
Mayur Rajeshwar Dandekar, Pankaj Mandpe, Swati Satalkar, Deepak Khobragade
pp. 1285–1299 · DOI: 10.5530/ijpi.20260231 · Published Oct-Dec 2026
Risk assessment in pharmaceutical manufacturing has become an essential component of modern pharmaceutical operations due to increasing regulatory requirements, complex supply chains, and growing quality and safety conce…
Review
Recent Advances in Bioactive Hydrogel Composites for Wound Healing: Mechanisms, Materials and Clinical Prospects
M Sindhu Kumari, Fatima Sanjeri Dasankoppa, Hasanpasha N Sholapur, M Mahesh Yadav, M.A. Umarfarooq, Arunkumar Gundaiah Ramesh, Pratiksha Akki, Akshay Shamnewadi, Rakshitha N Hemadri, Vijayakumar Murugesan
pp. 1300–1311 · DOI: 10.5530/ijpi.20260018 · Published Oct-Dec 2026
Wound healing is a complex and dynamic biological process that can be significantly impaired by infection, chronic inflammation, and underlying systemic conditions such as diabetes and vascular disorders. Conventional wo…
Review
Digital Defence in Healthcare: Medical Device Cyber Security in the EU and USA
Lakshmi Prasanthi Nori, Brahmaiah Bonthagarala, Cherukuri Harsha Vardhan, K.Lalitha Sri N V Sai Lakshmi, Sarapenta Sravani, Gumpati Supriya, Venkateswara Raju Kalidindi
pp. 1312–1322 · DOI: 10.5530/ijpi.20260296 · Published Oct-Dec 2026
The healthcare digitization changed the delivery of care to patients but also enhanced the exposure of medical devices to cyberattacks. The recalls of pacemakers and insulin pumps for being vulnerable to flaws underscore…
Review
Carbazoles and Tetrahydro carbazoles as Potential Therapeutic Agents- A Review on Its Chemistry, Synthesis and Biological Evaluation
Sree Janardhanan Vaithiyanathan, Nisha Vijayan Thankam, Mathan Swami, Ganna Anitha
pp. 1323–1337 · DOI: 10.5530/ijpi.20260023 · Published Oct-Dec 2026
Carbazoles and their partially saturated analogues, tetrahydrocarbazoles, have attracted considerable interest in medicinal chemistry owing to their broad spectrum of pharmacological activities and structural versatility…
Review
Integrative Approaches to Chronic Pain Management: Insights from Ayurveda and Modern Medicine
Sakshi Wankhede, Anil Pethe
pp. 1338–1345 · DOI: 10.5530/ijpi.20260198 · Published Oct-Dec 2026
Chronic pain is a major global health problem that reduces quality of life and strains healthcare systems. Conventional treatments often provide limited relief and cause side effects, highlighting the need for better the…
Review
From Data to Decisions: The Digital Transformation of Modern Healthcare
Lakshmi Prasanthi Nori, Nagineni Sudarshan Rao, Kiran Manda, M.S.Raghu Bapiraju, Yarra Priyanka, Boyina Lakshmi Venkata Maneesh, Addala Bhargavi Satya, Kondabolu Raghuram, K Venkateswara Raju
pp. 1346–1357 · DOI: 10.5530/ijpi.20260244 · Published Oct-Dec 2026
Digital health is a paradigm shift in healthcare, and it makes the industry data-driven, efficient, and patient-centered in terms of care delivery. The Digital Age in the realms of clinical and administrative has opened …
Review
Biological Mechanisms Driving Chemoresistance in Oral Squamous Cell Carcinoma (OSCC): A Review
Kaniga Pandi, Binoy Varghese Cheriyan, Nimithasree Keerthivasan, Mridula Dhanapal Saravanan, Dhanavarsha Govindaraj, Jai Anand Jagadeesan, Dinesh Kumar Eshwaravelu, Sam Helinto, Dharshini Jaisankar Hindumathi, Sowmiya Philip, Pradhosh Sakthivel, Rajeshkumar Thirupathi, Revathy Kumar
pp. 1358–1376 · DOI: 10.5530/ijpi.20260187 · Published Oct-Dec 2026
Drug resistance continues to be a major barrier to the successful treatment of Oral Squamous Cell Carcinoma (OSCC). Numerous processes, including the upregulation of efflux transporters, alterations in drug metabolism, a…
Review
Emerging Analytical Strategies for Screening Hydrochlorothiazide in Fixed Dose Combinations: A Comprehensive Review
Sree Janardhanan Vaithiyanathan, Nandini Goudar
pp. 1377–1383 · DOI: 10.5530/ijpi.20260005 · Published Oct-Dec 2026
Hydrochlorothiazide (HCTZ) is one of the most widely prescribed thiazide diuretics which is frequently formulated in fixed-dose combinations with angiotensin II receptor blockers, Angiotensin Converting Enzyme (ACE) inhi…
Review
Recent Progress in 3D Printing of Pharmaceuticals: Personalized Medicine and On-Demand Dosage Forms
Abubakar Mohamedali Omer Idress, Amgad Gamal Abdulrahman Abbas, R. Shirisha, K. Venkata Janardhanreddy, M. Rizwana, Nawaz Mahammed
pp. 1384–1395 · DOI: 10.5530/ijpi.20260162 · Published Oct-Dec 2026
Additive manufacturing (also referred to as 3D printing, 3DP) has become a disruptive technology in the pharmaceutics industry, providing an opportunity to produce individualized and custom dosage forms on demand. In con…
Review
Ozonated Oils for Wound Healing and Role of Emulgel on the Enhanced Topical Delivery
Sagar Mathad, Hasanpasha N Sholapur, Fatima Sanjeri Dasankoppa, Arunkumar Gundaiah Ramesh, Kamaladevi Kshatriya, Shreya Ajay Prabhu, Vijaykumar Meti, ST Bhagawati, Vijayakumar Murugesan
pp. 1396–1409 · DOI: 10.5530/ijpi.20260255 · Published Oct-Dec 2026
Wound healing, particularly in chronic and infected wounds, remains a major clinical challenge due to delayed tissue repair, poor oxygenation and rising antimicrobial resistance. Ozonated oils have emerged as promising t…

Original Article

Article
Influence of Gender and Educational Background on Pharmacy Students’ Perception of CAMs: A Survey-Based Study
Ramasamy Devendran Dhanushya, Ramaiyan Velmurugan, James Jemimah Smileyn, Rangadurai Pavithra, Babu Krishnapriya, Ravichandran Praveen
pp. 1410–1416 · DOI: 10.5530/ijpi.20260043 · Published Oct-Dec 2026
Background Complementary Alternative Medicine (CAMs) was extensively Utilized across countries for managing chronic and acute condition, with practices including Acupuncture, Ayurvedic, meditation, chiropractic, naturopa…
Article
Everolimus-Induced Hyperglycemia and its Clinical Significance: A Retrospective Study
Yukio Kadokawa, Akitoshi Tatsumi, Fukunori Kawahara, Saki Tanaka, Hiroki Osako, Satoshi Hasegawa, Kenji Takeda, Mari Takagi
pp. 1417–1423 · DOI: 10.5530/ijpi.20260121 · Published Oct-Dec 2026
Background Hyperglycemia frequently occurs during clinical administration of Everolimus (EVL). We investigated hyperglycemia occurrence after EVL administration in 52 Japanese patients with breast cancer, the treatment c…
Article
Monkeypox Transmission through Human Interaction: A Compartmental Model Study
Naresh Kumar Jothi, Senthil Kumar Dayalan, Deepa Sunder Rajan, Lakshmi Anil Madheshiya
pp. 1424–1433 · DOI: 10.5530/ijpi.20260052 · Published Oct-Dec 2026
Background In this study, with a mathematical model, we provide an epidemic model for Mpox virus infection. This paper aims to develop a mathematical epidemic model that captures some of the key characteristics of Mpox. …
Article
Design, Optimization, and Evaluation of Lincomycin Hydrochloride Transdermal Patches for Sustained Drug Release and Improved Antimicrobial Efficacy
Pratiksha Akki, M Mahesh Yadav, Fatima S Dasankoppa, Agadi Hiremath Viswanatha Swamy, M Pradeep Kumar, C. Manjula, Muneendra, Rohan Latwade, Shreya A. Prabhu, Reshma Vibhuti
pp. 1434–1444 · DOI: 10.5530/ijpi.20260139 · Published Oct-Dec 2026
Background: Antimicrobial Resistance (AMR) presents a major global health concern, necessitating the development of novel antimicrobial agents and effective drug delivery systems. Lincomycin hydrochloride, a lincosamide …
Article
Development of Azilsartan Nanoparticles via Hydrolysis for Enhanced Drug Delivery
Anbarasu Velan, Subramanian Somaskanthan
pp. 1445–1450 · DOI: 10.5530/ijpi.20260111 · Published Oct-Dec 2026
Background Hypertension is a major global health concern and a primary risk factor for cardiovascular morbidity and mortality. Azilsartan medoxomil, a novel angiotensin II receptor blocker, is effective in blood pressure…
Article
Simultaneous Estimation of Moxifloxacin and Tolfenamic Acid: Development and Validation of UV-visible, HPLC, and HPTLC Methods
Seema A. Gosavi, Pratiksha D. Bornare, Jyoti B. Tangde, Aditi S. Kulkarni
pp. 1451–1456 · DOI: 10.5530/ijpi.20260122 · Published Oct-Dec 2026
Objectives This research emphasizes validating the HPLC, HPTLC, and UV-visible techniques for the simultaneous quantitative measurement of Moxifloxacin (MOX) and Tolfenamic Acid (TA) in veterinary formulations. Materials…
Article
Pilot Study Evidence on Cardiac Benefits of Empagliflozin, A Changing Landscapes in Heart Failure Treatment
Robin George, Irshad Pasha, Bettur Jayappa Mahendra Kumar
pp. 1457–1463 · DOI: 10.5530/ijpi.20260206 · Published Oct-Dec 2026
Background Despite conventional cardiac agents, the prognosis of heart failure remains unmet to improve clinical presentations, and morbidity remains high. Growing evidence from multiple placebo-controlled studies on Sod…
Article
Statistical Optimization of Nano Emulsion-Based Gel of Efinaconazole for Onchomycosis
Sagarla Usharani, Mohammed Mahboob Shareef, Ruhi Anjum, Vasavi Devireddy, Naseeb Basha Shaik, Palghat Krishnamani Lakshmi, Prasanthi Domaraju
pp. 1464–1473 · DOI: 10.5530/ijpi.20260207 · Published Oct-Dec 2026
Background The objective of this study is to create a nano emulsion-based gel, of efinaconazole, a class II (BCS) antifungal medication for onchomycosis, by increasing solubility. Materials and Methods Solubility studies…
Article
Antibiotics Overuse in Wardha, India: A Cross-Sectional Survey on Knowledge, Attitudes, and Public Health Implications of Self-Medication
Susmita Mandal, Tejas Gadhave
pp. 1474–1478 · DOI: 10.5530/ijpi.20260135 · Published Oct-Dec 2026
Objectives Antimicrobial Resistance (AMR) is a growing public health crisis driven by the misuse and overuse of antibiotics. India, a major consumer of antibiotics, faces greater risks due to unregulated Over-the-Counter…
Article
In silico Study toward Electronic Structures of Bioactive Compounds Benzoquinone and its Derivatives: Toxicity and Molecular Docking against Cyclin-Dependent Kinase
Israa Jameel Hakeem
pp. 1479–1488 · DOI: 10.5530/ijpi.20260027 · Published Oct-Dec 2026
Background Cyclin-Dependent Kinase is one of the important part the cell cycle control systems and normally active in breast cancer. DFT calculations, ADMET predictions and molecular docking on ligands such as compound 1…
Article
A Process for Eco-Sustainable Extraction of Cytotoxic Flavonoids from Muntingia calabura L. using Sonication Method Optimized by Quality by Design Approach through Central Composite Model
Raj Deelip Mayanna, Siddhesh Santosh Bandekar, Shailendra Sanjay Suryawanshi, Mahesh Shivabasappa Palled, Priya Patil, Tanay Aniket Bhingurde, Sairaj Tukaram Bhogan, Ronak Dsouza, Yallurkar Siddhkala Suresh, Snehal Pundalik Yadav, Ashlesha Vilas Bhatakande, Soumya Ashok Biradar, Vrushali Vijay Patil, Arif Salim Jamadar
pp. 1489–1497 · DOI: 10.5530/ijpi.20260149 · Published Oct-Dec 2026
Background The present invention relates to an eco-sustainable, Quality by Design (QbD)- and Design of Experiments (DoE)-guided sonication-assisted extraction process for isolating cytotoxic flavonoid compounds from the …
Article
Predictive Application of Hansen Solubility Parameters in the Design of Methocarbamol-Ascorbic Acid Cocrystals for Solubility and Dissolution Enhancement
Muvvala Divya, Shaheen Begum, Mounika Yammani, Basuthkar Vanitha Bai, Dudekula Usha Rani
pp. 1498–1505 · DOI: 10.5530/ijpi.20260155 · Published Oct-Dec 2026
Background Methocarbamol, a centrally acting skeletal muscle relaxant, exhibits poor aqueous solubility, limiting its bioavailability. Cocrystallization offers a promising approach to enhance solubility and dissolution w…
Article
Design and Optimization of Agmatine Sulphate Loaded Solid Lipid Nanoparticles for Neurological Disorders: A DOE Approach
K H Harish, Agadi Hiremath Viswanatha Swamy
pp. 1506–1518 · DOI: 10.5530/ijpi.20260196 · Published Jul-Sep 2026
Objectives This study focuses on the formulation and optimization of Solid Lipid Nanoparticles (SLNs) containing agmatine sulfate, with the goal of enhancing its bioavailability and minimizing rapid metabolic degradation…
Article
Adverse Drug Reactions and their Determinants among Tuberculosis Patients Receiving Treatment at a Tertiary Care Centre in South India
Niloufur Syed Bashutheen, Arivarasan Barathi, Logeswari Balaji Mani, Sowmya Anbazhagan, Rajan Rushender
pp. 1519–1526 · DOI: 10.5530/ijpi.20260204 · Published Oct-Dec 2026
Introduction Tuberculosis (TB) remains a major public health challenge, exacerbated by Adverse Drug Reactions (ADRs) associated with anti-TB treatment. ADRs can lead to treatment discontinuation, drug resistance, and poo…
Article
Development and Validation of a New UV-Spectroscopic Method for the Estimation of Vortioxetine Hydrobromide in Bulk and Pharmaceutical Formulation
Nikhil Sunil Gawas, Meenaxi Maruti Maste
pp. 1527–1534 · DOI: 10.5530/ijpi.20260209 · Published Oct-Dec 2026
Background Major depressive disorders are treated with the antidepressant vortioxetine. In the current work, UV-Vis Spectroscopy was used to establish a new, simple, reliable, precise, selective, and ecologically sound a…
Article
Structure-based Screening of Bacopa monnieri Compounds as Potential Anti-Breast Cancer Agents
Maryam Musleh Althobiti
pp. 1535–1540 · DOI: 10.5530/ijpi.20260013 · Published Oct-Dec 2026
Background Breast Cancer (BC) is a major global health concern, particularly among women, and the fatality rate is increasing. Cyclooxygenase-2 (COX-2) is a critical enzyme that is overexpressed in various human cancers,…
Article
Influence of Geographical Diversity and Processing Methods on Nutritional Attributes of Finger Millet and Flax Seeds
Yogita Shinde, Gitanjali Deokar
pp. 1541–1549 · DOI: 10.5530/ijpi.20260222 · Published Oct-Dec 2026
Objectives Finger millet (Eleusine coracana) and flax seeds (Linum usitatissimum) are nutritious seeds and have multiple health benefits. But the nutrients, bioavailability, and functional quality of these foods may chan…
Article
Analytical Method for Estimation of Enalapril by UV Spectrophotometry Using Hydrotropic Solubilization: AGREE Metric Evaluation
Nuziveeti Lakshmi Durga Bhavani, Lankadi Devi, Bolapati Gayathri Priya, Bikkina Aruna, Bommina Abhisri, G. Yuthika Lakshmi, Lakshmi Prasanthi Nori
pp. 1550–1556 · DOI: 10.5530/ijpi.20260258 · Published Oct-Dec 2026
Objectives The objective of the current study was to design and confirm a green, eco-friendly UV-visible spectrophotometric system of estimating Enalapril maleate using safe and cost-effective solvents. Materials and Met…
Article
Maslinic Acid as a Candidate Small-Molecule CDK4 Inhibitor for Lung Cancer
Rashed Mohammed Alghamdi
pp. 1557–1566 · DOI: 10.5530/ijpi.20260020 · Published Oct-Dec 2026
Background Lung cancer is a significant cause of cancer-related death, emphasizing the need for current targeted therapies. CDK4, an imperative regulator of cell-cycle progression and the G1/S transition, is a promising …
Article
Neurodiversity-Inclusive Leadership: A Conceptual Framework for Enhancing Innovation and Organizational Climate
Tiyagura Nagaraja Kumari, Bachunaga Kishore Babu, Sree Pavani Vanteddu, K. Suryanarayana, Sripathi Kalvakolanu
pp. 1567–1577 · DOI: 10.5530/ijpi.20260260 · Published Oct-Dec 2026
Objectives This is a conceptual paper, which presents the Neurodiversity-Inclusive Leadership (NIL) as a unique model of leadership that incorporates cognitive diversity theory, psychological safety, strength-based strat…
Article
Integration of Green Chemistry Approach for Development of Box-Behnken Design Assisted RP-HPLC Method for Estimation of Nepafenac in Ophthalmic Dosage Form: A QbD Supported Degradation Approach
Divya Ratnakumar Patil, Mahesh Palled, Shailendra Sanjay Suryawanshi, Priya Prakash Shetti, Vrushali Patil, Tanay Bhingurde, Simran Gawas, Ronak Dsouza, Sairaj Bhogan, Rakshita Hirakal, Siddhesh Bandekar, Vittal Gavali
pp. 1578–1592 · DOI: 10.5530/ijpi.20260266 · Published Oct-Dec 2026
Background NSAIDs, or Non-Steroidal Anti-Inflammatory medicines, are a large family of chemically diverse medications with a wide range of effects. Nepafenac is an anti-inflammatory medication that is used topically as a…
Article
Quantitative Physicochemistry Meets Epitope Prediction: A Blueprint for Peptide Vaccine Design against DENV-3 NS5 MTase
Afaf Salim Alwabli
pp. 1593–1600 · DOI: 10.5530/ijpi.20260021 · Published Oct-Dec 2026
Background DENV NS5 is the most conserved viral protein; its N-terminal Methyltransferase (MTase) is essential for RNA capping and a prime drug target. The MTase domain mediates methylation of the viral RNA cap, ensuring…
Article
Multi-Target Inhibition of Breast Cancer Receptors by Pomegranate Peel Phytochemicals: An Integrated Docking, MD Simulation, and DFT Study
Magesh Mohan, Renukadevi Jeyavelkumaran, Sanjay Valliappan, Shakthi Harikrishnan, Kadir Aravindan, Balaji Ravikuma
pp. 1601–1621 · DOI: 10.5530/ijpi.20260291 · Published Oct-Dec 2026
Background Breast cancer progression is governed by highly interconnected signaling networks involving receptor tyrosine kinases and hormone-responsive nuclear receptors, which collectively drive tumor heterogeneity, ada…
Article
Comparative Analysis of Three COVID-19 Vaccines in Indian Metros
Md. Zeyaullah, Kamal Ahmad
pp. 1622–1628 · DOI: 10.5530/ijpi.20260014 · Published Oct-Dec 2026
Background This study evaluates COVID-19 vaccination coverage, vaccine effectiveness against SARS-CoV-2 variants, and associated health consequences in the five most important Indian metropolitan cities: Delhi, Mumbai, B…
Article
Development and Optimization of a Validated UV Spectrophotometric for Simultaneous Estimation of Thymoquinone and Temozolomide
Krutika Lolsure, Vijay Kumbar, Priya Shetti, Mitali Kubade, Malleswara Peram
pp. 1629–1634 · DOI: 10.5530/ijpi.20260016 · Published Oct-Dec 2026
Introduction Glioblastoma multiforme, an extremely aggressive form of brain cancer, presents significant challenges in treatment, despite the application of surgical intervention, radiation therapy, and chemotherapy. Res…
Article
Mechanistic Investigation of Hidden Flavonoids Isoorientin and Hyperin as Pancreatic Lipase Inhibitors Using Molecular Simulations and Machine Learning Correlation
Sruthi Sai Kaveripakam, Sreedevi Adikay, Sowmya Venkata Donthamsetty, Surekha Lakshmi Khandavilli
pp. 1635–1641 · DOI: 10.5530/ijpi.20260025 · Published Oct-Dec 2026
Background Phytochemicals exhibit diverse therapeutic properties with minimal adverse effects and documented their benefits against metabolic disorders. Inhibition of pancreatic lipase is a validated strategy for managin…
Article
Structure-Guided Virtual Screening and Molecular Dynamics Simulation of Selective Small-Molecule Inhibitors Targeting E3 Ubiquitin Ligase MDM2 in Breast Cancer
Tahani Bakhsh
pp. 1642–1656 · DOI: 10.5530/ijpi.20260058 · Published Oct-Dec 2026
Background MDM2 is an E3 ubiquitin ligase that suppresses p53, promotes its degradation, inhibits apoptosis, and drives uncontrolled cancer cell growth. Targeting the MDM2-p53 interaction is therefore a promising strateg…
Article
Thematic Structure and Evolution of a Pharmaceutical Sciences Research Corpus from Dr. Anroop Nair
K. K Mueen Ahmed, M Chaman Sab, Mohammed Yunus, Shery Jacob, Jigar N. Shah, Hiral J. Shah, Mahesh Attimarad, Sreeharsha Nagaraja, Rashed M. Almuqbil, Bandar E. Al-Dhubiab, Katharigatta N. Venugopala, Abdullah M. Alotaibi, Ahmed S. Alnaim
pp. 1657–1665 · DOI: 10.5530/ijpi.20260004 · Published Oct-Dec 2026
Objective Drug delivery and pharmaceutical-analysis research spans a wide range of sub-disciplines - nanocarrier formulation, transdermal and iontophoretic delivery, analytical method development, and computational drug …
Article
Development of a Paediatric-Friendly Pullulan-Based Mouth Dissolving Film of Ferrous Bisglycinate Using Factorial Design and Electronic Tongue-Assisted Taste Evaluation
Jahanvi Patel, Tejal Mehta
pp. 1666–1679 · DOI: 10.5530/ijpi.20260292 · Published Oct-Dec 2026
Background The primary objective of this study was to develop, optimize and evaluate a paediatric-friendly, pullulan-based Mouth Dissolving Film (MDF) of Ferrous Bisglycinate as a novel iron delivery system. The work aim…
Article
GC-MS and UV-visible Spectroscopic Analysis of Bioactive Phytochemical in Trigonella foenum-graecum Visible Spectroscopic
S. Revathy, K. Shoba, A. Vidhya
pp. 1680–1695 · DOI: 10.5530/ijpi.20260024 · Published Oct-Dec 2026
Background Trigonella foenum-graecum (fenugreek) is a widely utilized medicinal herb known for its therapeutic potential in managing metabolic disorders. This study aimed to extract and characterise the bioactive constit…
Article
Computational Simulation of Monoamine Oxidase (PDB ID: 2BXR) “Molecular Docking, Molecular Dynamics, and 3D-QSAR Analysis of 10H-Phenothiazin-1-yl Derivatives Targeting Enzymes”
Sanket Keshav Tambe, Rohit Jaysing Bhor, Sagar Dattatray Magar, Mayur Shivaji Bhosale, Shubham Popatrao Mankar, Datta Macchindra Abhale, Sachin Tukaram chavan, Gaurav Subhash Damre
pp. 1696–1718 · DOI: 10.5530/ijpi.20260011 · Published 2026
Background: This study focuses on the computational (in silico) analysis of 1H-phenothiazine derivatives to estimate their pharmacological potential, particularly as inhibitors of monoamine oxidase (PDB ID: 2BXR), an enz…
Article
Assessment of Health-Related Quality of Life after the Second Cycle of Chemotherapy in Esophageal Cancer Patients: A Prospective Cross-Sectional Study
Vishal Kulkarni, Kavya Mattikatti, Manasa Desai, Darshan Randewadi, Nida Sirdesai, Sanatkumar Bharamu Nyamagoud, AHM Viswanatha Swamy
pp. 1719–1724 · DOI: 10.5530/ijpi.20260176 · Published 2026
Aim: To evaluate early changes in symptom-specific Health-Related Quality of Life (HRQoL) among Esophageal cancer patients receiving chemotherapy up to the second cycle and to assess demographic and treatment-related dif…