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International Journal of Pharmaceutical InvestigationNOW IN
Article

Spectrophotometric Determination of Favipiravir in Bulk and Pharmaceutical Formulation Using Bromothymol Blue Reagent

Nandini Rebbbaniboni1, Seetha Mahithavani1, Gayatri Somayala1, Malladi Venkata Srihari Lakshman1, Jahnavi Bandla1★★ Corresponding author

  1. 1Department of Pharmaceutical Analysis, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak, Telangana, INDIA.

CORRESPONDENCE

Jahnavi Bandla

Department of Pharmaceutical Analysis, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak, Telangana, INDIA.

jahnavi.bandla@gmail.com

Received: 28-06-2023; Revised: 20-08-2023; Accepted: 31-10-2023.

Volume 14, Issue 1 · pp. 101–106 · PUBLISHED · DOI: 10.5530/ijpi.14.1.13

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ABSTRACT

Background: The primary objective of this research was to establish a spectrophotometric technique to quantitatively analyze the concentration of favipiravir in both its pure form and pharmaceutical preparations using bromothymol blue reagent. Materials and Methods: In this method, a yellow-colored chromagen was developed when favipiravir reacted with bromothymol blue reagent. Acetonitrile was selected as a solvent and the colored complex was detected at a wavelength of 475 nm. Results: The validation of the developed method was conducted following the guidelines set by the International Council for Harmonisation (ICH). The results demonstrated a strong linear relationship within the concentration range of 10-50 µg/ mL, exhibiting a correlation coefficient of 0.9995. Moreover, the developed method exhibited excellent accuracy, precision, specificity, and sensitivity Conclusion: For routine analysis purposes, this method can be readily utilized to determine the concentration of favipiravir in both bulk samples and pharmaceutical dosage forms.

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    Rebbbaniboni, N., Mahithavani, S., Somayala, G., Lakshman, M. V. S., & Bandla, J. (). Spectrophotometric Determination of Favipiravir in Bulk and Pharmaceutical Formulation Using Bromothymol Blue Reagent. International Journal of Pharmaceutical Investigation, 14(1), 101–106. https://doi.org/10.5530/ijpi.14.1.13